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Compound long-effect injection containing ceftiofur and meloxicam and preparation method thereof

A technology of ceftiofur and meloxicam, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, oil/fat/wax non-active ingredients, etc., can solve the restrictions on the development and application of compound injections, and the content of substances exceeds the standard , poor stability of ceftiofur, etc., to achieve the effect of enhancing animal compliance, promoting outcome and prognosis, and good stability

Inactive Publication Date: 2019-04-05
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, two problems occurred during the preparation process: 1. After the preparation was left for a long time to settle the drug particles, ceftiofur and meloxicam were clearly separated; 2. The stability of ceftiofur was poor, and the content of related substances often exceeded the standard, which limited Development and Application of Compound Injection of Thifur and Meloxicam

Method used

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  • Compound long-effect injection containing ceftiofur and meloxicam and preparation method thereof
  • Compound long-effect injection containing ceftiofur and meloxicam and preparation method thereof
  • Compound long-effect injection containing ceftiofur and meloxicam and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] prescription

[0040]

[0041] Preparation method: Take 1000mL of ethyl oleate, heat it to 170°C for 1 hour, then cool down to 120°C, take out 600mL, and cool down the rest of ethyl oleate to room temperature for constant volume. Add aluminum monostearate and hydrogenated castor oil to 600mL of ethyl oleate at a temperature of 120°C, and maintain at 120°C for 1.5 hours to completely gel the aluminum monostearate and hydrogenated castor oil; let cool to below 40°C, add Microcrystalline wax, Tween 80, Span 60, lecithin, α-tocopherol, ceftiofur hydrochloride (particle size D90≤5μm), meloxicam (particle size D90≤5μm), high pressure homogenization (pressure 20000psi) Treat for 1.5h; add ethyl oleate cooled to room temperature and make the volume to 1000mL. Check the particle size, related substances and content; subpackage after passing the test.

[0042] The in vitro performance evaluation of the prepared compound long-acting injection containing ceftiofur and meloxica...

Embodiment 2

[0050] prescription

[0051]

[0052] Preparation method: Take 1000mL of ethyl oleate, heat it to 160°C for 1 hour, then cool down to 130°C, take out 600mL, and cool down the remaining ethyl oleate to room temperature for constant volume. Add aluminum monostearate and hydrogenated castor oil to 600mL of ethyl oleate at a temperature of 130°C, and maintain at 130°C for 1 hour to completely gel the aluminum monostearate and hydrogenated castor oil; let cool to below 40°C, add spit Wen 80, Span 40, lecithin, propyl gallate, ceftiofur hydrochloride (particle size D90≤5μm), meloxicam (particle size D90≤5μm), high-speed shearing instrument (speed 25000 rpm) for 1.5 h; Add ethyl oleate cooled to room temperature and make the volume to 1000 mL. Detect the particle size, related substances and content; subpackage after passing the test, and obtain the compound long-acting injection containing ceftiofur and meloxicam, and evaluate its in vitro performance, including character, parti...

Embodiment 3

[0054] prescription

[0055]

[0056]

[0057] Preparation method: Take 1000mL of isopropyl myristate, heat to 160°C for 1 hour, then cool down to 120°C, take out 600mL, and cool the remaining isopropyl myristate to room temperature for constant volume. Add hydrogenated castor oil to 600mL of isopropyl myristate at 120°C, maintain at 120°C for 1 hour to make it completely gelled; let cool to below 40°C, add microcrystalline wax, Tween 80, Span 60, egg Phospholipids, propyl gallate, ceftiofur hydrochloride (particle size D90≤5μm), meloxicam (particle size D90≤5μm), high pressure homogenization (20000psi) treatment for 2h; add isopropyl myristate cooled to room temperature Capacity to 1000mL. Detect the particle size, related substances and content; subpackage after passing the test to obtain the compound long-acting injection containing ceftiofur and meloxicam, and evaluate its in vitro performance, including character, particle size, 3h sedimentation volume ratio, and r...

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Abstract

The invention discloses a compound long-effect injection containing ceftiofur and meloxicam. Every 1000 mL of injection contains 20 to 250 g of ceftiofur (based on ceftiofur), 4 to 80 g of meloxicam,1 to 50 g of macromolecular retardants, 1 to 50 g of wetting agents, 0.1 to 10 g of antioxidants and the balance of dispersion media. The granularity D90 of the ceftiofur is lower than or equal to 5 mum; the granularity D90 of meloxicam is lower than or equal to 5 mum. The injection has the advantages that the medicine microparticle mixing is uniform; the ceftiofur stability is good; just throughone injection, the injection can reach the treatment effect of one treatment coarse medication of 3 to 5 times of a conventional injection; both principal and secondary aspects of diseases can be treated; the cost is reduced; the time and the labor are saved; the animal stress is reduced, and the animal adaptability can be enhanced; the long-effect slow release effect is achieved; meanwhile, the medication safety is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to a compound long-acting injection containing ceftiofur and meloxicam and a preparation method thereof. Background technique [0002] Infectious diseases often cause inflammation, and with the aggravation of infection, symptoms such as fever and pain are caused, such as cow mastitis, metritis, laminitis, etc., bovine respiratory disease (BRD), swine pleuropneumonia, bronchitis, hemorrhagic Septicemia, etc., pneumonia in dogs and cats, etc. Fever, pain, and inflammation affect the animal's mental state and diet, damage the body, and seriously restrict the outcome and prognosis of bacterial diseases. Antimicrobial drugs can effectively eliminate pathogens, and antipyretic, analgesic and anti-inflammatory drugs can quickly relieve clinical symptoms. The combination of the two can treat both symptoms and root causes, promote the outcome of the disease, and improve ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/44A61K31/546A61K31/5415A61P31/04
CPCA61K9/0019A61K9/08A61K31/5415A61K31/546A61K47/44A61P31/04A61K2300/00
Inventor 余祖功郭凡溪
Owner NANJING AGRICULTURAL UNIVERSITY
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