Method for preparing alpha-phosphoramidate compound
A compound and phosphite technology, applied in chemical instruments and methods, compounds of Group 5/15 elements of the periodic table, organic compounds/hydrides/coordination complex catalysts, etc., can solve the problems of difficult recycling and catalyst preparation The process is complicated and cannot be recycled, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0081] Preparation of catalyst (ionic liquid):
[0082] Put 7.91g of triethylamine and 15.10g of trinitromethane in a 100mL round-bottomed flask and stir for 1-2 hours at normal temperature and pressure to obtain 23.01g of yellow liquid with a yield of 100%.
Embodiment 2
[0084] In a 25mL round bottom flask, add 10mmol (1.06g) benzaldehyde, 10.2mmol (0.95g) aniline, 10.3mmol (1.28g) trimethyl phosphite, 0.5mmol the catalyst prepared by Example 1, room temperature (15 ~25°C) for stirring and reacting for 30 minutes, adding water to quench the reaction, filtering, washing, and recrystallizing with an appropriate amount of ethanol to obtain α-anilino-benzyl dimethyl phosphate with a yield of 95%. The aqueous phase was washed twice with 2 mL of ethyl acetate, separated, and distilled at atmospheric pressure to recover the catalyst.
Embodiment 3
[0086] In a 250mL round bottom flask, add 10mmol (1.36g) 4-methoxybenzaldehyde, 10mmol (1.38g) 4-nitroaniline, 12mmol (1.32g) trimethyl phosphite, 0.01mmol catalyst, room temperature ( Stir the reaction at 15~25°C for 30 minutes, add water to quench the reaction, filter, wash, and recrystallize with an appropriate amount of ethanol to obtain α-(4-nitroanilino)-(4-methoxyphenyl)methylphosphoric acid di Methyl ester, yield 95%. The aqueous filtrate was washed twice with 2 mL of ethyl acetate, separated, and the water was distilled off under reduced pressure at a vacuum of 0.095 MPa to recover the catalyst.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com