Animal disease model capable of accurately positioning thoraco-abdominal aortic aneurysm

Abstract

The invention provides an animal disease model capable of accurately positioning thoraco-abdominal aortic aneurysm. According to a method, aorta ligation is used, and the thoraco-abdominal aortic aneurysm model capable of achieving accurate positioning is built, so that the aortic constriction degree is higher on the basis of thoracic aorta constriction, and the ligation position is more flexibleand is located on the arcus aortae part or the subhepatic aorta abdominalis part between the right innominate artery and the left common carotid artery; changes of high pressure and blood flow speed at the ligation position are used for inducing aortectasis, then the aorta structure and the hemodynamics are changed, the aortic aneurysm is caused, and observation can be conveniently achieved through modern medical means such as Doppler color ultrasound and section.

Description

technical field [0001] The invention relates to the technical fields of biology and medicine, in particular to establishing thoracic and abdominal aortic aneurysm animal disease models by aortic ligation. Background technique [0002] Aortic aneurysm is abnormal dilation and tumor-like protrusion of the aorta caused by aortic wall disease, often accompanied by aortic dissection. Aortic dissection is a tear of the aortic intima caused by various reasons (mainly degeneration or cystic necrosis of the aortic media). A false lumen is formed between the membrane and the media-adventitia, making the aortic lumen a true and false lumen. During this period, there may be one or several openings communicating. The false lumen can extend forward or reverse to each branch of the aorta to form corresponding regions. Manifestations of ischemia. The average age of onset of the disease is about 65 years old, and the male to female ratio is (2~5): 1. Tear-like pain in the chest or back is ...

AI Technical Summary

Problems solved by technology

At present, the most commonly used animal models in the cardiovascular field at home and abroad are myocardial infarction models and heart failure models induced by surgical intervention, while in the direction of large blood vessels, the main modeling method is the perfusion of drugs such as angiotensin, and the use of drugs to increase vascular pressure , reduce blood vessel elasticity and destroy vascular structure to establish aortic disease model, the molding effect is not good, the molding time is too long and difficult to control, and the mouse mortality rate is high

In addition, the commonly used model mice are APOE knockout mice, which are expensive, require many medications, and cannot determine the site of tumor formation, which affects the correspondence between the model and the research work of type A or type B dissection, lacks explanatory significance, and seriously restricts Promoted the extensive development of related research work on aortic aneurysm and dissection

Images