Porous titanium-tantalum-niobium-zirconium stent for bone defect repair

Abstract

The invention discloses a porous titanium-tantalum-niobium-zirconium stent for bone defect repair. The porous titanium-tantalum-niobium-zirconium stent contains, by weight, 55%-65% of titanium, 1%-5%of tantalum, 30%-35% of niobium and 2%-6% of zirconium; the porous titanium-tantalum-niobium-zirconium stent has a regular porous structure, pores are completely communicated, the pores are 300-500 microns, and the porosity is 78.3 + / - 1.6%. The elastic modulus of the porous titanium-tantalum-niobium-zirconium stent is 2.27-18.96 GPa. The porous titanium-tantalum-niobium-zirconium stent has the effect of promoting bone defect repair. The regular porous structure and the completely communicated pores facilitate the growth of a new bone into a material, and a better osseointegration effect is obtained. The pores of 300-500 microns and the porosity of 78.3 + / - 1.6% promote cell adhesion, promote the healing of bone defects and the growth of bone tissues.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a porous titanium-tantalum-niobium-zirconium bracket for bone defect repair. Background technique [0002] Bone defect is a common clinical disease. Various congenital diseases such as infection, tumor, trauma, surgical debridement after osteomyelitis are the main causes of bone defect. Depending on the size of the bone defect, the stability of the bone will be affected to varying degrees. A bone that has lost its stability is significantly less resistant to external impacts, so secondary fractures are very likely to occur under the action of a slight external force. In addition, due to the loss of part of the bone, the patient's fracture healing, bed rest and immobilization time will be significantly prolonged, which will bring a series of complications. In order to restore the stability of the bone and avoid secondary fractures, it is necessary to repair the bone defect in ...

AI Technical Summary

Problems solved by technology

There are different degrees of defects in autologous or allogeneic bone transplantation: (1) Autologous bone transplantation will increase surgical trauma and operation time. The available bone source is limited. Complications such as infection and pain

(2) Allogeneic bone transplantation may cause the spread of blood-borne diseases and cause immune reactions to interfere with bone healing; in addition, allogeneic bone only has osteoconduction but no osteoinduction

[0004] At present, the artificial bone substitutes used clinically for bone defect repair mainly have the following problems: (1) The elastic modulus of the implant does not match that of the bone, and stress shielding is likely to occur after implantation, which accelerates bone loss and secondary fractures Increased risk; (2) The implant does not have the biological function of promoting fracture healing, and only provides a stable environment for fracture healing; (3) Due to the limitations of traditional processing techniques, the shape of the filler does not match the defect, which will cause wear and tear And it may cause fracture again; (4) The porosity and irregular shape of porous materials processed by traditional techniques affect the effect of osseointegration

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