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A high-strength hydrogel system regulated by free radical polymerization crosslinking kinetics and its preparation method

A free radical and kinetic technology, applied in the field of hydrogels, can solve the problem of insignificant mechanical properties of gels, and achieve the effect of improving mechanical properties

Active Publication Date: 2020-01-17
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the technical problem that the mechanical properties of the existing kinetically regulated gels are not significantly improved, and provides a high-strength hydrogel system regulated by free radical polymerization crosslinking kinetics and a preparation method thereof. The present invention provides a simple Preparation of high-strength hydrogel system by adjusting the mechanical properties of the gel by using the reactivity of macromolecular cross-linking agents

Method used

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  • A high-strength hydrogel system regulated by free radical polymerization crosslinking kinetics and its preparation method
  • A high-strength hydrogel system regulated by free radical polymerization crosslinking kinetics and its preparation method
  • A high-strength hydrogel system regulated by free radical polymerization crosslinking kinetics and its preparation method

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preparation example Construction

[0037] Preferably, the preparation method of the block polymer of F127 end-capped by the allyl ether bond comprises the following steps:

[0038] (1) Add flaky potassium hydroxide, F127 block polyether in the reaction vessel, vacuum drying under 80 degrees centigrade;

[0039] (2) After cooling, blow nitrogen, add tetrahydrofuran and tribromopropene after dehydration into the reaction vessel, and react to obtain the block polymer macromolecular crosslinking agent of F127 terminated by allyl ether bonds.

[0040] The present invention also provides a method for preparing a high-strength hydrogel system regulated by free radical polymerization crosslinking kinetics, comprising the following steps:

[0041] (1) Dissolve the block polymer of F127 terminated by the allyl ether bond with the structure of formula i in pure water, add potassium persulfate initiator, and stir the acrylamide monomer at room temperature until it is completely dissolved;

[0042] (2) After the solution i...

Embodiment 1

[0048] Synthesis steps of F127 block polymer terminated by allyl ether bond 1.1 Add 10 g of F127 block polymer and 0.44 g of flake potassium hydroxide to a flask, then vacuumize at 80 degrees Celsius for two hours to remove water. After cooling down, under the protection of an inert atmosphere, 100 mL of dried tetrahydrofuran was added, and 0.96 g of tribromopropene was slowly added dropwise into the flask under an ice-water bath. Raise the temperature to room temperature and react for 24 hours. The reaction solution was concentrated and precipitated in 500 mL of ether. The white precipitate was collected, washed 2-3 times with ether, and dried to obtain an allyl ether bond-terminated F127DE block polymer with the structure of formula i.

[0049] Utilize nuclear magnetic resonance to analyze the block polymer with formula i structure obtained in the present embodiment, obtain proton nuclear magnetic resonance spectrum, as figure 1 shown. Depend on figure 1 It can be seen fro...

Embodiment 2

[0051] Add 0.6 g of allyl ether bond-terminated F127 block polymer with i structure, 8 mL of deionized water, 1.7 g of acrylamide monomer and 0.0065 g of potassium persulfate into the flask, stir at room temperature to fully dissolve. The containing solution was frozen and thawed in liquid nitrogen to deoxygenate and poured into a glass mold. After sealing, it was heated and polymerized in a water bath at 50 degrees Celsius for 12 hours to obtain a strong hydrogel.

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Abstract

The invention relates to the technical field of hydrogels, in particular to a high-strength hydrogel system controlled by free radical polymerization cross-linking kinetics and a preparation method thereof. The technical problem that mechanical properties of existing kinetic-controlled gel are not significantly enhanced is solved. According to the high-strength hydrogel system controlled by free radical polymerization cross-linking kinetics, allyl end group with low reactivity is used as a macromolecular cross-linking agent to be modified on a micelle-forming block polymer F127(HO(C2H4O)99-(C3H6O)70-(C2H4O)99H); and with the response characteristics of the macromolecular cross-linking agent and an acrylamide monomer, a uniformly dispersed and internally cross-linked micelle cross-linking point is formed in the gel. The obtained hydrogel has superior tensile properties, and has a broad application prospect in the field of biomedical applications, such as biosensors, artificial organs, tissue repair materials, drug controlled release, etc.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a high-strength hydrogel system regulated by free radical polymerization crosslinking kinetics and a preparation method thereof. Background technique [0002] Hydrogel is a kind of highly water-containing material with a three-dimensional network structure. It can form a porous cross-linked network structure through chemical cross-linking and physical cross-linking. Its water content can often reach more than 90%, even under the condition of external force. , and it is not easy to lose moisture. As a "soft and wet" material, hydrogel has excellent biocompatibility, high water absorption and retention, stimuli responsiveness, and low sliding friction. With these excellent properties, hydrogels have a wide range of applications in many fields, including tissue engineering, medical wound dressings, soft electronic materials, superabsorbent materials, and water-retaining agents fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F283/06C08F220/56
CPCC08F283/065C08F220/56
Inventor 杨小牛俞晓峰吕红英吴海洋秦泽昭袁黎光屈宝留
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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