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Magnesium-silver coating for medical implant materials and preparation method of magnesium-silver coating

An implant material, silver coating technology, used in joint replacement and human tissue defect filling materials and implant materials antibacterial, dental implants, medical materials fields, can solve problems such as poor histocompatibility, infection, etc. , to achieve the effect of promoting wound healing, enhancing the possibility, and promoting the differentiation of fibroblasts

Inactive Publication Date: 2019-04-19
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the tissue combination and infection problems of implant materials, the present invention provides a magnesium-silver coating for medical implant materials and a preparation method thereof. Prepare a magnesium-silver coating on the surface of a solid or porous structure substrate to solve the poor histocompatibility and infection problems of existing implant materials. The coating obtained by this method has excellent biocompatibility and has a bactericidal function

Method used

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  • Magnesium-silver coating for medical implant materials and preparation method of magnesium-silver coating

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Experimental program
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Effect test

Embodiment 1

[0025] Put the porous titanium alloy (Ti-6Al-4V) sample into the deposition chamber furnace body 1, put the MgAg alloy raw material into the evaporation chamber furnace body 2, then connect the gas circuit, check the sealing condition, and pump the ultimate vacuum (10 -5 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 20°C, the evaporation temperature to 500°C, and the working pressure to 1×10 -4 Pa, the deposition time is 1 h, the thickness of the deposited metal magnesium-silver layer is 5 μm, and the mass percentage of silver is 2%. In order to confirm the osteogenic effect of the coating, an alkaline phosphatase (ALP) experiment was carried out. After 4 days and 7 days of culture, the color of the coating group was darker than that of the matrix group, indicating that the activity of alkaline phosphatase in the coating group was higher than that of the matrix. group, indicati...

Embodiment 2

[0027] Put the plane pure substrate into the furnace body 1 of the deposition chamber, put the MgAg alloy raw material into the furnace body 2 of the evaporation chamber, then connect the gas circuit, check the sealing condition, and pump the ultimate vacuum (10 -5 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 80°C, the evaporation temperature to 600°C, and the working pressure to 1×10 -3 Pa, the deposition time is 1 h, the thickness of the deposited metal magnesium-silver layer is 50 μm, and the mass percentage of silver is 3%. After X-ray diffraction analysis and scanning electron microscope energy spectrum analysis, it is determined that the coating is magnesium silver. Due to the low content of silver, the X-ray spectrum can only show the diffraction information of metal magnesium.

Embodiment 3

[0029] Put the flat 316L stainless steel sheet into the deposition chamber furnace body 1, put the MgAg alloy raw material into the evaporation chamber furnace body 2, then connect the gas circuit, check the sealing condition, and pump the ultimate vacuum (10 -5 Pa), the whole system was repeatedly purged 3 times with argon to ensure that the oxygen content was minimized. Set the deposition temperature to 100°C, the evaporation temperature to 700°C, and the working vacuum to 1×10 -1 Pa, the deposition time is 1.5 h, the thickness of the deposited metal magnesium-silver layer is 100 μm, and the mass percentage of silver is 4%.

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Abstract

In order to solve the problems of osseointegration and infection of implant materials, the invention provides a magnesium-silver coating for medical implant materials and a preparation method of the magnesium-silver coating. An evaporation technology is adopted for preparing the magnesium-silver coating on a substance prepared through pure titanium, titanium alloy, stainless steel and polymer materials or on a porous structural substrate, the thickness of the coating is 0.1-200 [mu]m, and the mass ratio of the silver elements in the coating is greater than 0% and less than or equal to 10%. Thebone compatibility and infection problems of the existing implant materials can be solved, and the permanent implant materials obtained through the method meet the mechanical property requirements ofvarious implant positions, and have excellent biocompatibility and the sterilization function.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to dental implants, joint replacements and filling materials for human tissue defects and the field of implant material antibacterial technology; specifically, the magnesium-silver coating material on the surface of the implant and its preparation method . Background technique [0002] Implants such as artificial joints only have a lifespan of 10-15 years due to adverse cell reactions caused by implant loosening and abrasion, which cannot meet the long-term use requirements. Meanwhile, infection remains one of the disastrous postoperative complications of orthopedic implants. Metallic foreign bodies implanted in the body are risk factors for such infections, and a series of in vivo reactions, including the weakening of macrophage function and the passivation of the local immune system, create favorable conditions for the proliferation of pathogens. In addition, the proteins adsorb...

Claims

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Application Information

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IPC IPC(8): C23C14/16C23C14/20C23C14/24A61L27/30A61L27/54A61L27/58
CPCA61L27/306A61L27/54A61L27/58A61L2300/102A61L2300/104A61L2300/404A61L2300/412A61L2420/02C23C14/16C23C14/20C23C14/24
Inventor 于晓明谭丽丽杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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