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A kind of ephedra homogeneous polysaccharide esp-b4 and its preparation method and application

An ESP-B4, homogeneous technology, applied in the field of ephedra homogeneous polysaccharide ESP-B4 and its preparation, can solve the problems of side effects, lack of therapeutic drugs and the like

Active Publication Date: 2021-03-30
王秋红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simple anti-inflammatory and anti-pathogenic bacteria treatment is difficult to change the occurrence and development of lung injury, and there is a lack of effective therapeutic drugs in clinical practice. At present, only a large number of hormones can be used to prevent inflammation and reduce lung injury, which also brings great side effects during treatment.

Method used

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  • A kind of ephedra homogeneous polysaccharide esp-b4 and its preparation method and application
  • A kind of ephedra homogeneous polysaccharide esp-b4 and its preparation method and application
  • A kind of ephedra homogeneous polysaccharide esp-b4 and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: the preparation method of ephedra homogeneous polysaccharide ESP-B4

[0054] Ephedra dried herbaceous stem coarse powder 200kg, heat and reflux extraction with 95% industrial ethanol for 3 times, each time for 3 hours, remove alkaloids, pigments, polyphenols and oligosaccharides in ephedra, and extract the dregs of ephedra for ephedra Extraction of polysaccharides. The dregs were decocted with water for 3 times, 3 hours each time, filtered after cooling, and the filtrates were combined. The extracted medicinal residues were dried naturally, the filtrate was recovered under reduced pressure, and freeze-dried to obtain 14kg of total polysaccharides (PB) extracted from ephedra ephedra, which were connected in series by IRA-401 (5×50cm, i.d.) + Amberlite FPC3500 (5×50cm, i.d.) Resin column, first use distilled water as eluent, flow rate 10ml / min, phenol-sulfuric acid method detection, when the sugar-free component flows out, use 1M NaCl to elute until the sug...

Embodiment 2

[0061] Embodiment 2: A kind of anti-acute lung injury and / or respiratory distress syndrome (ALI / ARDS) tablet

[0062] Take an appropriate amount of the homogeneous polysaccharide ESP-B4 prepared in Example 1, add diluent, disintegrant and other auxiliary materials, mix well, make granules, dry, compress into tablets, coat or spray film coat.

Embodiment 3

[0063] Embodiment 3: a kind of anti-acute lung injury and / or respiratory distress syndrome (ALI / ARDS) oral liquid

[0064] Take an appropriate amount of the homogeneous polysaccharide ESP-B4 prepared in Example 1, add an appropriate amount of water to dissolve, mix well, add flavoring agent and preservative, mix well, sub-package, sterilize, and get ready.

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Abstract

The present invention relates to a homogeneous polysaccharide ESP-B4 of ephedra and its preparation method and use. The homogeneous polysaccharide ESP-B4 of ephedra is a polysaccharide monomer prepared from ephedra and is an acidic heteropolysaccharide. The HPSEC-ELSD spectrum is shown as A single symmetrical peak consists of xylose, arabinose, glucose, rhamnose, mannose, galactose, glucuronic acid and galacturonic acid in a molar ratio of 1.0:4.5:1.0:2.0:1.0:5.5:1.5:50 The composition, molecular weight is 2.37×107Da, and the galacturonic acid content reaches a molar ratio of more than 75.2%. The Ephedra homogeneous polysaccharide ESP-B4 has significant anti-infectious acute lung injury activity and can be used for major infectious acute lung injury caused by SARS virus, influenza A virus, avian influenza virus; as well as Escherichia coli, Pseudomonas aeruginosa It is suitable for the treatment of lung damage caused by common infections such as bacilli, pneumococci, and influenza viruses. It has significant therapeutic effects, is safe and has no side effects, has a simple preparation method, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a homogeneous ephedra polysaccharide ESP-B4, a preparation method and an application thereof. Background technique [0002] Acute lung injury (Acute lung injury, ALI) can deteriorate into respiratory distress syndrome (Acuterespiratory distress syndrome, ARDS), manifested as rapid respiratory failure and severe arterial blood hypoxia that is not easily treated by oxygen infusion, leading to multiple organ failure, with relatively severe High fatality rate. It is a critical illness with high morbidity and mortality in clinical practice. The fatality rate of ALI / ARDS is as high as 45%-50%. If it is accompanied by sepsis, the fatality rate will be as high as 90%. The fatality rate will be further increased if it is accompanied by multiple organ dysfunction. If it is complicated by more than 4 organ disorders, the fatality rate will be 100%. %. The clinical manifestations of m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P11/00A61P31/04A61P31/14A61P31/16
CPCA61P11/00A61P31/04A61P31/14A61P31/16A61K31/715C08B37/0003C08B37/006A61K2236/331A61K2236/39A61K2236/53A61K36/17A61K9/0095A61K9/0019Y02A50/30A61K9/19A61K9/20A61K9/4808
Inventor 王秋红匡海学夏永刚杨炳友邢娜林晓婷
Owner 王秋红