Tumor-targeted self-carrying system and preparation method and applications thereof
A tumor targeting and system technology, applied in the field of biomedicine, can solve the problems of low efficiency, no active targeting ability of apoptotic peptides, unsatisfactory tumor treatment effect, etc., to achieve convenient operation, good cell targeting ability, The effect of prolonging blood circulation time
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0050] Example 1 Synthesis of tumor targeting self-delivery system
[0051] (1) Synthesis of amphiphilic apoptosis peptide
[0052] The amphiphilic apoptotic peptide is formed by adding two N-fluorenylmethyloxycarbonyl groups to the last lysine of the amino acid sequence shown in SEQ ID NO:1, which is D-lysine-leucine-alanine Acid-Lysine-Leucine-Alanine-Lysine-Lysine-Leucine-Alanine-Lysine-Leucine-Alanine-Lysine-Glycine-Cysteine Amino Acid-Lysine (N-Fluorenyl Methoxycarbonyl) 2 (KLAKLAKKLAKLAKGCK(Fmoc) 2 ).
[0053] Those skilled in the art can use solid-phase synthesis or liquid-phase synthesis to synthesize the above-mentioned amphiphilic apoptotic peptides. In this application, the inventors used solid-phase synthesis to synthesize the peptides. The main steps are as follows:
[0054] 1) Weigh 1g of 2-chloro-trityl chloride resin (1.20mmol / g) in a clean solid phase synthesis column, and swell the resin with 10mL of N,N-dimethylformamide for 1.5h, and then remove by suction filtrat...
PUM
Property | Measurement | Unit |
---|---|---|
Hydrated particle size | aaaaa | aaaaa |
Hydrated particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap