Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of chitosan-based medicine-carrying flexible sponge

A technology of chitosan and chitosan gel, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of poor stability of chitosan sponge, long process cycle, and inconvenient drug loading, and achieve convenient drug loading, The effect of short process cycle and improved safety in use

Inactive Publication Date: 2019-05-14
NANJING UNIV OF SCI & TECH
View PDF6 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of poor stability, poor elasticity, inconvenient drug loading and long process cycle of the chitosan sponge prepared by the existing method, the invention provides a preparation method of a chitosan-based drug-loaded flexible sponge

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of chitosan-based medicine-carrying flexible sponge
  • Preparation method of chitosan-based medicine-carrying flexible sponge
  • Preparation method of chitosan-based medicine-carrying flexible sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of chitosan-based drug-loaded flexible sponge, concrete steps are:

[0035] Step 1: Dissolve chitosan in 2% (v / v) acetic acid solution at room temperature, prepare 0.5% (w / v) chitosan acetic acid solution, dissolve sodium hydroxide in deionized water, and prepare 4% (w / v) solution.

[0036] Step 2: Under magnetic stirring, slowly add excess sodium hydroxide solution dropwise to the chitosan acetic acid solution until the white flocculent chitosan gel precipitates completely, and continues stirring for 30 minutes to fully disperse the precipitate.

[0037] Step 3: Wash the chitosan gel precipitate 4 times with high-speed deionized water, the centrifugation parameter is 70 rpm, and the centrifugation time is 5 minutes.

[0038] Step 4: According to the mass ratio of 8:1, mix the chitosan gel precipitation with 4% oxidized carboxymethyl cellulose solution, add 3% glycerol, and then press the drug loading ratio chitosan gel precipitation / hydrochloric acid ...

Embodiment 2

[0044] The preparation of chitosan-based drug-loaded flexible sponge, concrete steps are:

[0045] Step 1: Dissolve chitosan in 2% (v / v) acetic acid solution at room temperature, prepare 2.0% (w / v) chitosan acetic acid solution, dissolve sodium hydroxide in deionized water, and prepare 4% (w / v) solution.

[0046] Step 2: Under magnetic stirring, slowly add excess sodium hydroxide solution dropwise to the chitosan acetic acid solution until a white flocculent gel precipitate of chitosan is completely precipitated, and continue stirring for 30 minutes to fully disperse the precipitate.

[0047] Step 3: Wash the chitosan gel precipitate 4 times with high-speed deionized water, the centrifugation parameter is 70 rpm, and the centrifugation time is 5 minutes.

[0048] Step 4: Mix chitosan gel precipitation with oxidized carboxymethyl cellulose at a mass ratio of 1:1, add 3% glycerin, and then set the drug-loading ratio of chitosan gel precipitation / tetracycline hydrochloride to 15...

Embodiment 3

[0050] The preparation of chitosan-based drug-loaded flexible sponge, concrete steps are:

[0051] Step 1: Dissolve chitosan in 2% (v / v) acetic acid solution at room temperature, prepare 0.5% (w / v) chitosan acetic acid solution, dissolve sodium hydroxide in deionized water, and prepare 4% (w / v) solution.

[0052] Step 2: Under magnetic stirring, slowly add excess sodium hydroxide solution dropwise to the chitosan acetic acid solution until the white flocculent chitosan gel precipitates completely, and continues stirring for 30 minutes to fully disperse the precipitate;

[0053] Step 3: Wash the chitosan gel precipitate 4 times with high-speed deionized water, the centrifugation parameter is 70 rpm, and the centrifugation time is 5 minutes.

[0054] Step 4: Mix the chitosan gel precipitation with oxidized carboxymethyl cellulose at a mass ratio of 8:1, add 6% glycerin, and then set the drug-loading ratio of chitosan gel precipitation / tetracycline hydrochloride to 3000:1 Tetracy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of chitosan-based medicine-carrying flexible sponge. The method comprises the following steps: taking chitosan as raw material, dropwisely adding a precipitant sodium hydroxide to obtain chitosan gel precipitate in the process of continuously stirring an acetic acid solution of chitosan, centrifugally cleaning the chitosan gel precipitate, and then mixing the chitosan gel precipitate with a cross-linking agent of oxidizing carboxymethyl cellulose, a plasticizer glycerol and an antibacterial drug tetracycline hydrochloride, and freeze-drying the castfilm to obtain the medicine-carrying flexible sponge body. According to the invention, the chitosan gel precipitate prepared by acid-base titration is used for preparing the sponge body, and the stability of the sponge obtained by freeze-drying is good, and the structure is not damaged when swelling is caused, and one-step molding is carried out, and the structure collapse caused by alkali washing and secondary freeze-drying is avoided, and because of the one-step molding, the chitosan-based medicine-carrying flexible sponge is convenient to carry medicine. According to the invention, glycerol is added as a plasticizer, so that the sponge is soft and elastic. The method has the advantages of short process period, simple and convenient process, low cost and suitability for commercial production.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and relates to a preparation method of a chitosan-based drug-loaded flexible sponge. Background technique [0002] Dressing is a medical material used to temporarily cover a wound. Its main function is to protect the wound, absorb wound exudate, provide an environment conducive to wound healing, and protect the wound from contamination by bacteria and dust particles. There are many types of medical dressings, which can be divided into sponge, hydrogel, film, fiber and other dressings according to their shape. Different forms of dressings have different performances, and dressings should be selected reasonably according to the type of wound and the stage of wound recovery. Because of its well-developed pore network structure, excellent water absorption performance, and stable structure, sponge dressings are especially suitable for wounds with large wound exudate and the early stage of wound ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L15/42A61L15/44A61L15/28
Inventor 谈华平马烨凌中华陈勇
Owner NANJING UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com