Preparation method and application of high strength and porous structure polyvinyl alcohol-gallotannic acid hydrogel

A technology of polyvinyl alcohol and porous structure, which is applied in the field of cartilage repair and biomaterials, can solve the problems of complex preparation process, material toxicity, pore structure, etc., and achieve the effect of simple operation, stable properties and solving both problems

Active Publication Date: 2019-05-17
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical crosslinking, nanomaterial blending, double crosslinking network / semi-interpenetrating network hydrogel and other methods are commonly used to improve the mechanical properties of porous hydrogels, but these methods often bring toxicity problems, pore structure problems, and The preparation process is complicated

Method used

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  • Preparation method and application of high strength and porous structure polyvinyl alcohol-gallotannic acid hydrogel
  • Preparation method and application of high strength and porous structure polyvinyl alcohol-gallotannic acid hydrogel
  • Preparation method and application of high strength and porous structure polyvinyl alcohol-gallotannic acid hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] a) Add 10g of PVA, 1g of TA, 3g of calcium carbonate, and 1g of poloxamer 407 into 85mL of deionized water, heat in a constant temperature water bath at 90°C, and stir until the PVA is completely melted and the remaining substances are evenly mixed to obtain a mixed solution A.

[0029] b) Place the mixed solution A at room temperature and continue to stir until the temperature drops to 25°C for later use. Add 3 mL of acetic acid dropwise to the above mixed solution A according to a certain volume, and continue to stir until the calcium carbonate and acetic acid fully react to generate microbubbles to obtain the mixed solution B.

[0030] c) Pour the mixed solution B into the mold and perform a freeze-thaw cycle. The freezing temperature is -20°C, the freezing time is 15 hours, the thawing temperature is 15°C, and the thawing time is 12 hours. The number of cycles was 3 times to obtain a polyvinyl alcohol hydrogel.

[0031] Based on the PVA-TA hydrogel prepared by the ...

Embodiment 2

[0036] a) Add 20g of PVA, 4g of TA, 2g of calcium carbonate, and 1g of poloxamer 407 into 73mL of deionized water, heat in a constant temperature water bath at 95°C, and stir until the PVA is completely melted and the rest of the ingredients are evenly mixed to obtain a mixture A.

[0037] b) Put the mixed solution A at room temperature and keep stirring, and lower the temperature to 40°C for later use. 3 mL of hydrochloric acid with a mass fraction of 15% was added dropwise to the above mixed solution A according to a certain volume, and the stirring was continued until the calcium carbonate and hydrochloric acid fully reacted to generate microbubbles, and mixed solution B was obtained.

[0038] c) Pour the mixed solution B into the mold, and perform a freeze-thaw cycle. The freezing temperature is -18°C, the freezing time is 20h, and the thawing temperature is 20°C, and the thawing time is 4h. The number of cycles is 2 times to obtain polyvinyl alcohol hydrogel.

[0039] Ba...

Embodiment 3

[0041] a) Add 13g of PVA, 2g of TA, 4g of calcium carbonate, and 1g of poloxamer 407 into 80mL of deionized water, heat in a constant temperature water bath at 99°C, and stir until the PVA is completely melted and the remaining substances are evenly mixed to obtain a mixed solution A.

[0042] b) Place the mixed solution A at room temperature and continue to stir until the temperature drops to 30°C for later use. Add 5 mL of citric acid to the above mixed solution A drop by drop according to a certain volume, and continue to stir until the calcium carbonate and acetic acid fully react to generate microbubbles to obtain the mixed solution B.

[0043] c) Pour the mixed solution B into the mold and perform a freeze-thaw cycle. The freezing temperature is -25°C, the freezing time is 18 hours, and the thawing temperature is 23°C, and the thawing time is 6 hours. The number of cycles was 4 times to obtain a polyvinyl alcohol hydrogel.

[0044] Based on the PVA-TA hydrogel prepared ...

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Abstract

The invention belongs to the field of articular cartilage repair materials, and provides a preparation method and application of high strength and porous structure polyvinyl alcohol-gallotannic acid hydrogel. The hydrogel is a potential articular cartilage replacement material. According to the preparation method, polyvinyl alcohol is adopted as a substrate material, the ice crystal forming ability of a hydrogel precursor solution is improved by introducing gallotannic acid and microbubbles, and meanwhile, the mechanical property of the hydrogel is greatly enhanced due to the intermolecular interaction between the gallotannic acid and the polyvinyl alcohol. The porous structure and high strength hydrogel is prepared at one step, the preparation process is simple, repeatability is high, theobtained hydrogel has good biocompatibility, meets a porous environment for adhesion and proliferation of cartilage cells and the mechanical property similar to natural articular cartilage, and can be applied to the field of articular cartilage replacement materials.

Description

technical field [0001] The invention belongs to the field of biomaterials, in particular to the field of articular cartilage repair, in particular to a preparation method of polyvinyl alcohol-tannic acid hydrogel with high strength and porous structure and its application in the field of cartilage repair. Background technique [0002] Hydrogel is a three-dimensional network structure obtained by physical bonding or chemical crosslinking of polymers. Because it has a large number of hydrophilic groups, hydrogel has a high affinity for water and can absorb a large amount of water. The high water content makes them more similar to natural living tissue than other synthetic biomaterials. Among them, polyvinyl alcohol (PVA) hydrogel is considered to be an ideal articular cartilage substitute material due to its stable chemical properties, non-toxicity, no side effects, and good biocompatibility. [0003] Although polyvinyl alcohol hydrogel can meet the needs of articular cartila...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L29/04C08K5/1545A61L27/00A61L27/16A61L27/50A61L27/52A61L27/56
Inventor 张伟李姮王森吴承伟
Owner DALIAN UNIV OF TECH
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