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Preparation method of highly stable oral mucosa repair material

A technology for oral mucosa and repair materials, applied in the field of medical materials, can solve problems such as poor hydrophilicity, flexibility and stability, and poor biocompatibility, achieve complex shapes, improve mechanical properties, and shorten the duration of oral ulcers Effect

Inactive Publication Date: 2019-05-24
雷江文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention: Aiming at the poor hydrophilicity of the existing oral film materials, the poor biocompatibility with tissue cells, and the defects in flexibility and stability, a strong stable film material is provided. Preparation method of oral mucosa repair material

Method used

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  • Preparation method of highly stable oral mucosa repair material

Examples

Experimental program
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Effect test

example 1

[0027] According to the mass ratio of 1:10, add propolis to 70% ethanol solution with mass fraction, stir and mix and extract twice at 55°C, control the single extraction time to 20h, and filter and collect after the extraction is completed Filtrate, place the filtrate at 75°C and 0.02MPa under reduced pressure and evaporate to 1 / 5 of the original volume to obtain a rotary evaporated liquid and vacuum freeze-dry, grind at room temperature through a 200-mesh sieve to obtain abrasive particles, calculated in parts by weight , respectively weigh 45 parts of chloroform, 4 parts of absolute ethanol and 6 parts of grinding particles and place them in the Erlenmeyer flask, stir and mix and dropwise add 1% mass fraction of sodium hydroxide solution to the Erlenmeyer flask to control the amount of sodium hydroxide solution added The mass is the same as that of chloroform, and the dropping rate is 1mL / min. After the dropwise addition is completed, add 1% hydrochloric acid dropwise to the...

example 2

[0029] According to the mass ratio of 1:10, add propolis to 70% ethanol solution by mass fraction, stir and mix and extract twice at 57°C, and control the single extraction time to 22h. After the extraction is completed, filter and collect Filtrate, place the filtrate at 77°C and 0.03MPa under reduced pressure and evaporate to 1 / 5 of the original volume to obtain a rotary evaporated liquid and vacuum freeze-dry, grind at room temperature through a 200-mesh sieve to obtain abrasive particles, calculated in parts by weight , respectively weigh 47 parts of chloroform, 4 parts of absolute ethanol and 7 parts of grinding particles and place them in the Erlenmeyer flask, stir and mix and dropwise add mass fraction 1% sodium hydroxide solution to the Erlenmeyer flask to control the amount of sodium hydroxide solution added The mass is the same as chloroform, and the dropping rate is 2mL / min. After the dropwise addition is completed, add 1% hydrochloric acid dropwise to the Erlenmeyer ...

example 3

[0031] According to the mass ratio of 1:10, add propolis to 70% ethanol solution by mass fraction, stir and mix and extract 3 times at 60°C, and control the single extraction time to 24h. After the extraction is completed, filter and collect Filtrate, place the filtrate at 80°C and 0.05MPa under reduced pressure and evaporate to 1 / 5 of the original volume, obtain a rotary evaporated liquid and vacuum freeze-dry, grind at room temperature through a 200-mesh sieve to obtain abrasive particles, calculated in parts by weight , respectively weigh 50 parts of chloroform, 5 parts of absolute ethanol and 8 parts of grinding particles and place them in the Erlenmeyer flask, stir and mix and dropwise add 1% mass fraction of sodium hydroxide solution to the Erlenmeyer flask to control the amount of sodium hydroxide solution added The mass is the same as that of chloroform, and the dropping rate is 2mL / min. After the dropwise addition is completed, add 1% hydrochloric acid dropwise to the ...

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Abstract

The invention relates to a preparation method of a highly stable oral mucosa repair material, and belongs to the technical field of medical materials. The technical scheme includes that by the aid ofa collagen composite propolis small-molecule gel material, collagen serves as attachment and supports of cell growth, proliferation, differentiation and migration of epithelial cells can be induced, the can serve as a carrier to release antibacterial agents, the relationship between the collagen and wound healing process is close, a propolis small-molecule has toughness similar to rubber and low surface tension, double bonds of a monomer can trigger polymerization and copolymerization reaction to form a polymer with physical characteristics similar to a viable tissue, the propolis small-molecule gel material and the collagen are compounded to serve as a slow-release film matrix dosage form for packaging the antibacterial agents, seepage can be sufficiently absorbed to facilitate dissolution and removal of necrotic tissues of wound surface, constriction degree of the wound surface is reduced, growth of epithelium and granulation tissues can be facilitated, and mechanical properties of material are effectively improved.

Description

technical field [0001] The invention relates to a preparation method of a strong and stable oral mucosa repair material, which belongs to the technical field of medical materials. Background technique [0002] The oral mucosa is the lining of the oral cavity and has an important function of protecting various tissues under the mucosa. However, oral tissue defects due to various reasons such as tumors, trauma, inflammation, and congenital defects require repair and reconstruction of oral mucosal tissue. Clinically, methods such as free skin grafts, local transfer mucosal flaps, and fascial flaps are mainly used for its repair. Its shortcomings include the following two points: first, it needs to open up a second operation area, and the damage is relatively large; second, the transplanted skin and tissue flaps will not be transformed into mucous membranes, and epithelial keratinization, secretion, and hair growth will remain for many years after surgery. The characteristics ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61K35/644A61P1/02
Inventor 雷江文
Owner 雷江文
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