Seawater immersion wound resuscitation liquid and preparation and application methods thereof

A technology of resuscitation fluid and sea water, applied in the field of medicine for trauma treatment, can solve problems such as inability to achieve rehydration treatment, and achieve the effects of improving mitochondrial function, correcting mean arterial pressure, and correcting acid-base balance disorders

Inactive Publication Date: 2019-05-24
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is mentioned that hyaluronic acid and its salts, cross-linked hyaluronic acid and its salts have moderate swelling properties, good seawater barrier effect, skin adhesion and hemostatic function in water, can form a protective layer on the wound, and achieve rapid hemostasis, The effect of isolating seawater is used to prevent and treat the seafoam injury and its complications formed by seawater soaked wounds after the wounded fall into the water, and to promote wound healing. However, it can only form an isolation layer on the surface of the wound to temporarily protect the skin from seawater. Further immersion damage, can not achieve the effect of rehydration treatment

Method used

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  • Seawater immersion wound resuscitation liquid and preparation and application methods thereof
  • Seawater immersion wound resuscitation liquid and preparation and application methods thereof
  • Seawater immersion wound resuscitation liquid and preparation and application methods thereof

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preparation example Construction

[0032]The present invention also provides a method for preparing the above-mentioned resuscitation solution, specifically: first mix physiological saline and 5wt% glucose solution, then add dextran 70, sodium bicarbonate, dexamethasone and levofloxacin, filter and sterilize after completely dissolving, High temperature and high pressure sterilization can obtain the resuscitation solution of the present invention.

[0033] The resuscitation fluid of the present invention adopts the method of intravenous infusion during use, and can be supplemented by clinicians according to the anti-shock rehydration formula combined with the patient's height and weight according to the situation of physical shock and critical condition. When the biochemical indicators return to normal, the infusion can be stopped.

Embodiment

[0035] According to the above preparation method, a series of resuscitation fluids of the present invention for treating seawater immersion injuries were prepared, the composition of which is shown in Table 1.

[0036] Table 1 The present invention is used for the composition of the resuscitating liquid that treats seawater immersion injury

[0037]

[0038]

experiment example

[0040] 1. Materials and methods

[0041] 1. Configuration of artificial seawater

[0042] The artificial seawater used in the experiment refers to the main components of seawater in the southeast coast of my country provided by the Second Institute of Oceanography of the State Oceanic Administration, and combined with literature (such as Xue Xiaojun, Zhang Wenhua, Zhou Song, etc.). Intervention effect [J]. Liberation Army Medical Journal, 2013,25:35-38. etc.) report preparation, the specific components are: sodium chloride 26.5g / L, magnesium sulfate 3.3g / L, magnesium chloride 2.45g / L, chloride Calcium 1.14g / L, potassium chloride 0.73g / L, sodium bicarbonate 0.2g / L, sodium bromide 0.08g / L, osmotic pressure 1250-1350mmol / L, pH 7.9-8.1, seawater specific gravity 1.020- 1.025, with an average temperature of 22°C.

[0043] 2. Establishment of animal models

[0044] Miniature pigs have extensive similarities with humans in many aspects such as anatomy and physiological metabolism, an...

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Abstract

The invention discloses a seawater immersion wound resuscitation liquid and preparation and application methods thereof. Every 100 ml of the seawater immersion wound resuscitation liquid is composed of 40-60 ml of normal saline, 40-60 ml of 5 wt% glucose solution, 1.5-2.5 g of dextran 70 and 4-6 g of sodium bicarbonate. When applied to fluid infusion treatment on miniature pigs with seawater immersion wounds, the seawater immersion wound resuscitation liquid can successfully correct electrolyte disturbance and accordingly prove the effectiveness.

Description

technical field [0001] The invention relates to the technical field of medicines for wound treatment, in particular to a resuscitation fluid for treating seawater immersion injuries and its preparation method and application. Background technique [0002] Seawater is a hypertonic, alkaline, low-temperature, bacteria-rich liquid, which can cause strong complex physical and chemical stimulation and pollution to the human body, and is a common acute injury in modern naval warfare. Different from traditional land battle injuries, seawater immersion injuries can lead to severe microcirculatory disturbance, strong inflammatory response, tissue and cell swelling, disruption of body fluid and electrolyte balance, decreased body resistance, secondary tissue damage, and severe infection. [0003] At present, most of the drugs used in the actual clinical treatment of seawater immersion injuries are single ingredients. For example, the Chinese invention patent application with the publ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61P17/02A61P3/12A61P9/02A61K31/7004A61K31/721A61K33/00A61K31/5383A61K31/573
Inventor 乔治唐云陈志达郗洪庆陈凛
Owner GENERAL HOSPITAL OF PLA
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