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Collagen dressing containing PCL microspheres and preparation method and 3D printing application thereof

A collagen and microsphere technology, used in medical science, bandages, additive processing, etc., can solve the problems of complex process, harsh preparation conditions, wound infection, etc., to improve porosity and air permeability, and promote wound repair and healing. , the effect of high mechanical properties and toughness

Inactive Publication Date: 2019-05-24
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of dressing directly prints the inorganic compound on the surface of the gauze. It can isolate the external environment, but it cannot accelerate wound healing, and it is easy to cause secondary damage when changing dressings due to adhesion with wound secretions. Therefore, it is of great significance to develop new dressings.
Chinese patent CN108714238A discloses a fibroin / titanium porous composite medical dressing loaded with radiation-resistant microorganisms and its preparation method. The preparation of this dressing needs to be processed in a low-temperature environment from -20 to -80°C, and the preparation conditions are harsh and the process is complicated. , high cost; in addition, this kind of dressing does not have antibacterial properties, and the wound is susceptible to bacterial infection during the wound repair process using this dressing, which is not conducive to wound repair

Method used

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  • Collagen dressing containing PCL microspheres and preparation method and 3D printing application thereof
  • Collagen dressing containing PCL microspheres and preparation method and 3D printing application thereof
  • Collagen dressing containing PCL microspheres and preparation method and 3D printing application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method for 3D printing a collagen dressing containing PCL microspheres, comprising the following steps:

[0027] (1) Weigh 0.06 g of enrofloxacin and 0.225 g of polycaprolactone (PCL) into 3 ml of dichloromethane, and ultrasonically disperse at room temperature for 20 minutes to form an oil phase; in addition, weigh 0.3 g of hydroxyapatite Add HAP to 9 mL of deionized water, stir and disperse at room temperature for 30 min to form a water phase; use a pipette to measure the above oil phase and add it to the water phase (the ratio between the water phase and the oil phase is 3 : 1), use a vortex mixer to shake for 10 min to form an oil-in-water emulsion;

[0028] (2) Pour the oil-in-water emulsion obtained in the above step (1) into a petri dish, let the dichloromethane volatilize naturally for 24 hours, and finally obtain white powdery PCL drug-loaded microspheres;

[0029] (3) Weigh 0.3 g of collagen, 0.6 g of hydroxyapatite (HAP), and 1.2 g of sodium al...

Embodiment 2

[0032] A preparation method for 3D printing a collagen dressing containing PCL microspheres, comprising the following steps:

[0033] (1) Weigh 0.06 g of enrofloxacin and 0.225 g of polycaprolactone (PCL) into 3 ml of dichloromethane, and ultrasonically disperse at room temperature for 20 minutes to form an oil phase; in addition, weigh 0.3 g of hydroxyapatite Add HAP to 9 mL of deionized water, stir and disperse at room temperature for 30 min to form a water phase; use a pipette to measure the above oil phase and add it to the water phase (the ratio between the water phase and the oil phase is 3 : 1), use a vortex mixer to shake for 10 min to form an oil-in-water emulsion;

[0034] (2) Pour the oil-in-water emulsion obtained in the above step (1) into a petri dish, let the dichloromethane volatilize naturally for 24 hours, and finally obtain white powdery PCL drug-loaded microspheres;

[0035] (3) Weigh 0.3 g of collagen, 0.6 g of hydroxyapatite (HAP), and 1.5 g of sodium al...

Embodiment 3

[0038] A preparation method for 3D printing a collagen dressing containing PCL microspheres, comprising the following steps:

[0039](1) Weigh 0.06 g of enrofloxacin and 0.225 g of polycaprolactone (PCL) into 3 ml of dichloromethane, and ultrasonically disperse at room temperature for 20 minutes to form an oil phase; in addition, weigh 0.3 g of hydroxyapatite Add HAP to 9 mL of deionized water, stir and disperse at room temperature for 30 min to form a water phase; use a pipette to measure the above oil phase and add it to the water phase (the ratio between the water phase and the oil phase is 3 : 1), use a vortex mixer to shake for 10 min to form an oil-in-water emulsion;

[0040] (2) Pour the oil-in-water emulsion obtained in the above step (1) into a petri dish, let the dichloromethane volatilize naturally for 24 hours, and finally obtain white powdery PCL drug-loaded microspheres;

[0041] (3) Weigh 0.3 g of collagen, 0.6 g of hydroxyapatite (HAP), and 1.8 g of sodium alg...

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Abstract

The invention belongs to the field of biological medical materials, and particularly relates to a collagen dressing containing polycaprolactone microspheres. The collagen dressing comprises water, andeach 100mL of the water contains 0.5-4g of collagen, 1-15g of hydroxyapatite, 0.5-3g of PCL drug-carrying microspheres, 2-5g of glucolactone and 3-8g of sodium alginate. A collagen / alginate hydrogelmaterial is prepared by combining collagen with an alginate solution through a simple composite gel path, and a medical material with high bioactivity and compatibility and capable of loading and slowly releasing drug can be obtained; by adding the PCL microspheres loaded with drug, stress scattering effect can be realized, and mechanical performance of the collagen dressing is improved; due to drug loading, slow release of the drug can be realized, the collagen dressing of 3D printing can be prevented from being polluted by bacteria, antibacterial and bactericidal effects can be realized, andwound repair and healing are facilitated.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a collagen dressing containing polycaprolactone (PCL) microspheres for 3D printing and a preparation method thereof. Background technique [0002] Collagen is the main component of the extracellular matrix and an important structural protein in animal connective tissue. Natural collagen has the advantages of good biocompatibility, biodegradability, hydrophilicity, non-toxicity, etc., and has a wide range of applications in the field of medical functional materials such as tissue engineering scaffolds, wound dressings, and drug carriers. The skin is the largest organ and the most important natural defense line of the human body, and it may be damaged at any time due to extensive exposure to the external environment. Some minor injuries that only involve the epidermis can heal on their own, but wounds that involve severe injuries to the epidermis and dermis are difficult to hea...

Claims

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Application Information

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IPC IPC(8): A61L26/00B33Y10/00B33Y80/00
Inventor 周武艺刘水凤胡洋张坚诚廖振斌陈柏睿董先明
Owner SOUTH CHINA AGRI UNIV
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