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A method for recovering phosphorus resources and organic matter in levofosfomycin dextrophenethylamine salt industrial wastewater

A technology for L-fosfomycin and phenethylamine salt, which is applied in the field of recovering phosphorus resources and organic matter in industrial wastewater of L-fosfomycin and phenethylamine salt, and can solve strict storage conditions, large safety risks, large solvent consumption, etc. problem, to achieve the effect of high safety, green processing process, and increase economic added value.

Active Publication Date: 2019-09-13
南京道尔医药研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Raw material H for common oxidative degradation methods 2 o 2 The amount of solvent used is large, the storage conditions are strict, and it is easy to degrade during storage, which poses a greater safety risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Hydrolysis reaction stage: Take 10 L of industrial wastewater of levofosfomycin and d-phenylethylamine salt, filter it with a plate and frame filter press, put it in a 50 L stainless steel reactor, and adjust the temperature of the reactor to 35°C. Adjust the rotation speed of the electric stirring paddle to 45rpm, and slowly add saturated Ca(OH) to the reaction kettle 2 Solution, adjust the pH value to 8.2, at this time the total amount of the solution is about 18L. Slowly add 4L of recovered toluene solution, and continue stirring for 3h.

[0023] (2) Filtration and separation stage: the suspension was stirred and cooled to room temperature 22° C., and the suspension obtained after hydrolysis was filtered using a centrifugal filter with a rotating speed of 2500 rpm to obtain 0.66 kg of fosfomycin calcium salt. The filtered solution was placed in a stainless steel reaction kettle and stood still for 1.5 hours. After the solution was separated, 15.8L of aqueous pha...

Embodiment 2

[0026] (1) Hydrolysis reaction stage: Take 10 L of industrial wastewater of levofosfomycin and d-phenylethylamine salt, filter it with a plate and frame filter press, put it in a 50 L stainless steel reactor, and adjust the temperature of the reactor to 40°C. Adjust the speed of the electric stirring paddle to 50rpm, and slowly add saturated Ca(OH) to the reaction kettle 2 Solution, adjust the pH value to 8.6, at this time the total amount of the solution is about 20L. Slowly add 5L of the recovered toluene solution, and continue stirring for 3h.

[0027] (2) Filtration and separation stage: the suspension was stirred and cooled to room temperature 25° C., and the suspension obtained after hydrolysis was filtered using a centrifugal filter with a rotating speed of 3000 rpm to obtain 0.85 kg of fosfomycin calcium salt. The filtered solution was placed in a stainless steel reaction kettle and left to stand for 1 hour. After the solution was separated, 17.7L of aqueous phase and...

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PUM

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Abstract

The invention discloses a method for recycling phosphorus resource and organic matter in levofosfomycin dextrophenylethylamine salt industrial wastewater. The method includes: adding a saturated Ca(OH)2 solution into the industrial wastewater, hydrolyzing two main optical isomers into fosfomycin calcium and phenylethylamine, using methylbenzene to extract phenylethylamine for recycling, and usingNaClO to oxidatively degrade fosfomycin calcium obtained by filtering into Ca3(PO4)2 for recycling, wherein treated wastewater is an inorganic salt solution. The method is environment-friendly, safe,simple, convenient and capable of effectively recycling the phosphorus resource and the organic matter in the industrial wastewater.

Description

technical field [0001] The invention relates to a method for recovering phosphorus resources and organic matter in levofosfomycin-dextrophenethylamine salt industrial wastewater, belonging to the technical field of sewage treatment and resource utilization. Background technique [0002] Fosfomycin was discovered in the culture solution of actinomycetes in 1969, and it began to be sold in the EU market in 1973, and it has been used for more than 40 years. Modern studies have shown that fosfomycin is effective against a variety of Gram-positive (G+) bacteria and Gram-negative (G-) bacteria, including some drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, broad-spectrum β-endobacteria Gram bacteria with amidase, vancomycin-resistant enterococci, etc., all maintained high antibacterial activity. Because of its unique mechanism of action, it has a synergistic effect when used in combination with antibiotics such as β-lactams, fluoroquinolones, aminogl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/655C07C209/86C07C211/27C01B25/32
Inventor 王琦李好瑾彭晗彭菲菲
Owner 南京道尔医药研究院有限公司