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Anti-gout gel agent and preparation method and application thereof

A gel and anti-gout technology, applied in anti-inflammatory agents, non-central analgesics, pharmaceutical formulations, etc., can solve the problem of single treatment of medicinal materials, achieve the goal of reducing joint swelling, reducing the increase ratio, and prolonging the pain threshold Effect

Active Publication Date: 2019-05-31
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few medicinal materials for single Chinese medicine treatment. The most commonly used ones are rhubarb and plantain, but the conventional Chinese medicine treatment methods are mostly oral administration.

Method used

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  • Anti-gout gel agent and preparation method and application thereof
  • Anti-gout gel agent and preparation method and application thereof
  • Anti-gout gel agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Anti-inflammatory activity of amaranth extract.

[0049] 1 Experimental method

[0050] 1.1 Preparation of Amaranthaceae Extract Layer

[0051] Firstly, the undried plants of Amaranthaceae were crushed with a superfine pulverizer, weighed 500g, extracted with 10 times the amount of 95% ethanol, and refluxed in a constant temperature water bath at 80°C, once for 2 hours, and extracted 3 times in total. Collect the extract and concentrate it to 400mL with a rotary evaporator at 60°C, then extract it with petroleum ether 1:1, then remove the lower layer (that is, the upper layer is petroleum ether layer) and continue to extract with ethyl acetate 1:1, After stratification, the lower layer is the water layer, and the upper layer is the ethyl acetate layer. The three groups of extracts extracted above were selected to continue the following experiments.

[0052] 1.2 The effect of each extraction layer on the mouse ear swelling and inflammation model induced by xylene

[...

Embodiment 2

[0073] Study on the technology of amaranth extract gel.

[0074] 1 Experimental method

[0075] 1.1 Research on water layer extraction process

[0076] 1.1.1 Orthogonal test method to optimize the extraction process of water layer extract

[0077] (1) Water layer: it is obtained by sequentially extracting and extracting according to the orthogonal test, and the content is determined as required.

[0078] (2) Orthogonally take the total flavonoid content, total alkaloid content, and water layer yield score as indicators, and adopt the three-item comprehensive scoring method. Scoring criteria: the highest total flavonoid content is 35 points; the highest total alkaloid content is 35 points; the highest water layer yield is 30 points, and the total score is calculated by accumulating the three scores.

[0079] This experiment uses the method of water-alcohol water-bath reflux extraction, with the number of times of extraction, the concentration of ethanol, the amount of ethano...

Embodiment 3

[0179] Anti-inflammatory and analgesic effects of anti-gout gel on rats with acute gouty arthritis.

[0180] 1 Experimental method

[0181] 1.1 Animal feeding conditions

[0182] SPF-grade Wistar rats, female, weighing 180-200 g, were provided by Changchun Yisi Experimental Animal Technology Co., Ltd., and the breeding hygiene license number is SCXK (Ji)-2016-0003. Raise in separate cages, the room temperature is 22-24°C, food and drink are free, and the litter is replaced regularly.

[0183] 1.2 Establishment of acute gouty arthritis model and administration in groups

[0184]Rats were first anesthetized and anesthetized by intraperitoneal injection of 40 mg / kg sodium pentobarbital. The experiment refers to Coderre TJ (Coderre TJ, Wall PD. Ankle joint orate arthritis in rats: an alternative animal model of arthritis to that produced by Freund's adjuvant [J]. Pain. 1987 (28): 379-393.) and improved Chen's method (Chen Wenzhao, Guan Shiliang. Effect of Fangji Huangmao Wujie...

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Abstract

The invention relates to an anti-gout gel agent and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The gel agent comprises the following raw materials by weight: 1.5-4.0 parts of amaranth extract, 1.0-3.0 parts of gel skeleton material, 20-40 parts of solvent, 5.0-15.0 parts of promoter, 2.5-7.7 parts of humectants and1.5-4.0 parts of stabilizer. The anti-gout gel agent is a hydrogel system, wherein the hydrogel skeleton system is stable in nature, not only has extremely simple preparation, but also has relativelylow cost, and achieves good production advantages accordingly. The gel agent is fed through cutaneous penetration as a carrier, has excellent toughness, flexibility, moldability, high drug loading capacity, good drug release performance, non toxicity and no irritation, and can be widely used in clinical practices.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an anti-gout gel and its preparation method and application. Background technique [0002] Gout is a group of heterogeneous diseases caused by chronic purine metabolic disorders. Clinical features are hyperuricemia, recurrent acute gouty arthritis, tophi, and interstitial nephritis, and in severe cases, joint deformities and dysfunction. Acute gouty arthritis is the most common first symptom in gout patients. Acute gouty arthritis (acute gouty arthritis) is due to abnormal uric acid excretion disorders in the patient's body, resulting in monosodium urate deposition in the synovium. It is a series of inflammatory symptoms caused by tissues such as cartilage and cartilage. It is an acute onset of inflammation. Patients often wake up in the morning or late at night because they feel severe pain in the joints like tearing and biting. Redness, heat,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/21A61K9/06A61K47/10A61K47/26A61P19/06A61P19/02A61P29/00
Inventor 杜培革王曼力安丽萍赵南晰苑广信李洪宇徐广宇盛瑜韩笑孙晶波郭笑王锰田程张婧郭冰洁
Owner BEIHUA UNIV
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