Preparation and application of a dendrimer-modified reversed-phase/strong anion-exchange mixed-mode polymer

A technology of dendritic macromolecules and strong anions, which is applied to the materials of anion exchangers, anion exchange, ion exchange of chelates, etc.

Active Publication Date: 2021-04-27
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports of PAMAM dendrimer-modified reversed-phase / strong anion-exchange mixed-mode polymer materials used as solid-phase extraction fillers to enrich and purify acidic drugs in complex sample matrices

Method used

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  • Preparation and application of a dendrimer-modified reversed-phase/strong anion-exchange mixed-mode polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035](1) Preparation of polymer microspheres

[0036]30 mmol (4.10 mL) of methacrylate (GMA), 20 mmol (2.85 mL) Diathylbenzene and 60 mg of azo diisobutyronitrile were dissolved in a porogen containing 6.87 g of toluene, and prepared a solution. A, the solution is placed in an ice bath, ultrasonic degassing 10 min, then the oxygen molecule is removed from the solution A. NANO-SIO with 80 mg particle size 12nm2Different to 10 ml of mass concentration of 0.02% Tritonx-100 aqueous solution, ultrasound 10min let Nano-SiO2Dispersed, then 3 ml of solution A was added, and then stirred with a homogenizer 6000 rpm / min, then the air was sealed from the air above the body 3 min, and the obtained Pickering emulsion was polymerized at 60 ° C for 24 h. After the reaction was completed, then 400 mesh and 230 mesh for stainless steel sieve, then use acetone to settle twice, 10 min each time, obtaining a particle size of 38-63 μm, polymer PGMA-SiO2. With methanol to extract the solvent, Sodhow extr...

Embodiment 2

[0038]30 mmol (4.10 mL) of methacrylate (GMA), 20 mmol (2.85 mL) Diathylbenzene and 60 mg of azo diisobutyronitrile (9 / 1, W) containing toluene / 1-diol (9 / 1, W) In a porogen solution of / W at (6.87 g), a solution A was prepared, and the solution was placed in an ice bath, ultrasonic degassed 10 min, and then the oxygen molecule was removed from the solution A. NANO-SIO with 80 mg particle size 12nm2Dissatis to 10 ml of mass concentration of 0.02% aqueous Tritonx-100 aqueous solution, ultrasound 5min let Nano-SiO2Dispersed, then 3 ml of solution A was added, and then stirred with a homogenizer 6000 rpm / min, then the air was sealed from the air above the body 3 min, and the obtained Pickering emulsion was polymerized at 60 ° C for 24 h. After the reaction was completed, then 400 mesh and 230 mesh for stainless steel sieve, then use acetone to settle twice, 10 min each time, obtaining a particle size of 38-63 μm, polymer PGMA-SiO2. With methanol to extract the solvent, Sodhow extra...

Embodiment 3

[0040]30 mmol (4.10 mL) of methacrylate (GMA), 20 mmol (2.85 mL) divinylbenzene and 60 mg of azo diisobutyronitrile (7 / 3, W) containing toluene / 1-tertiacol (7 / 3, W) In a porogen solution of / W at (6.87 g), a solution A was prepared, and the solution was placed in an ice bath, ultrasonic degassed 10 min, and then the oxygen molecule was removed from the solution A. NANO-SIO with 80 mg particle size 12nm2Dissatis to 10 ml of mass concentration of 0.02% aqueous Tritonx-100 aqueous solution, ultrasound 5min let Nano-SiO2Dispersed, then 3 ml of solution A was added, and then stirred with a homogenizer 6000 rpm / min, then the air was sealed from the air above the body 3 min, and the obtained Pickering emulsion was polymerized at 60 ° C for 24 h. After the reaction was completed, then 400 mesh and 230 mesh for stainless steel sieve, then use acetone to settle twice, 10 min each time, obtaining a particle size of 38-63 μm, polymer PGMA-SiO2. With methanol to extract the solvent, Sodhow ...

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Abstract

The invention provides a method and application for preparing a dendrimer-modified reversed-phase / strong anion-exchange mixed-mode adsorbent. Specifically, the cross-linking agent, functional monomer, and initiator are dissolved in the porogen, and nitrogen gas is introduced to remove oxygen to prepare solution A, and nano-SiO 2 Disperse in Triton X-100 aqueous solution to obtain solution B, mix solution A and solution B, disperse with homogenizer and polymerize at 60°C, the obtained surface is coated with SiO 2 The polymer with ethylenediamine undergoes epoxy-amine ring-opening reaction at 80°C to obtain a polymer with amine groups, which is soaked in hydrofluoric acid to remove SiO 2 To obtain G0-PGMA, then modify the surface of G0-PGMA with dendrimer polyamide-amine (PAMAM) by two-step reaction, and finally obtain the dendrimer-modified reversed-phase / strong Anion exchange mixed mode sorbent.

Description

Technical field[0001]The present invention belongs to the field of environmental monitoring and new materials, and more particularly to the preparation and application of a dendritic macromolecular modified inversion of highly selective enriched purified weak acidic compounds.Background technique[0002]Sample pre-processing is an important step in the analysis process. Biological samples (such as blood, serum and urine) and environmental samples, food samples are complex, the content of the target analyte is very low (Ng / mL-μg / ml), even with high resolution analysis instruments, almost all Samples are not directly analyzed. Therefore, the enrichment and purification of the sample is critical in the sample analysis. Common sample pre-treatment techniques are liquid extraction, solid phase extraction, pressure solvent extraction, and the like. Solid phase extraction is the most widely used sample pre-treatment technique for the most widely used sample pre-treatment technique due to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C02F1/26B01D15/08B01D15/36
Inventor 陈吉平黄超囡李云彭俊钰
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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