Method for measuring famoxadone in water
A technology of oxazolidone and a determination method, applied in the field of analytical chemistry, can solve the problems of high detection limit, unstable gas chromatographic peaks, poor reproducibility, etc., and achieves low detection limit and improved stability. Effect
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[0023] A method for assaying oxacone in water, comprising
[0024] Sampling steps: take 1ml of water sample;
[0025] Determination steps: the water sample is subjected to liquid phase tandem mass spectrometry;
[0026] Wherein, liquid chromatography condition is as follows:
[0027] Waters ACQUITY UPLC BEH C 18 Column (50mm x 2.1mm, 1.7μm) chromatographic column; column temperature 40°C; injection volume 1μL; flow rate 0.3mL / min; mobile phase A is 0.05% ammonium acetate aqueous solution, B is methanol. Gradient elution program: 0.00~1.00min, 85%~85%A; 1.00~2.00min, 85%~15%A; 2.00~3.00min, 15%~15%A; 3.00~4.00min, 15%~ 85%A; 4.00~5.00min, 85%~85%A.
[0028] The mass spectrometry conditions are as follows:
[0029] Electrospray ion source; positive ion scan; capillary voltage 0.5kV; ion source temperature 150°C; desolvated gas 500°C; desolvated gas flow (nitrogen) 800L / h; Mode detection; the characteristic ion mass spectrometry parameters of oxaflucone are 392 / 238, 392 / 93....
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