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Nano silicon dioxide/polymer material guided bone regeneration composite porous membrane and preparation method thereof

A technology of nano-silica and polymer materials, applied in tissue regeneration, medical science, prostheses, etc., can solve the problem of slow degradation rate, increased probability of allergic reaction of patients to guided bone regeneration membrane, hydrophobicity and slow degradation rate, cell Low adhesion and other problems, to achieve the effect of improving cell adhesion, increasing dielectric constant, and good biocompatibility

Inactive Publication Date: 2019-07-09
青岛杰圣博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The guided bone regeneration membrane needs to have good biodegradability and absorbability, high strength and high cell adhesion, but the guided bone regeneration membrane currently on the market is difficult to meet the above conditions at the same time. For example, the polytetrafluoroethylene membrane has high strength , but it is non-degradable and must be removed by secondary surgery, which increases the risk of infection for the patient; due to its hydrophobicity and slow degradation rate, the polycaprolactone membrane has low cell adhesion, and the slow degradation rate increases the patient's ability to guide bone regeneration Membrane allergic reaction probability

Method used

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  • Nano silicon dioxide/polymer material guided bone regeneration composite porous membrane and preparation method thereof
  • Nano silicon dioxide/polymer material guided bone regeneration composite porous membrane and preparation method thereof
  • Nano silicon dioxide/polymer material guided bone regeneration composite porous membrane and preparation method thereof

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Embodiment 1

[0034] A nano-silica / polymer material guided bone regeneration composite porous film, the thickness is 0.1mm, the mass ratio of nano-silica and polymer material is 1:2; the polymer material is poly N-isopropyl Acrylamide-polycaprolactone-polyethylene glycol copolymer;

[0035] Wherein poly-N-isopropylacrylamide-polycaprolactone-polyethylene glycol copolymer is prepared according to the following steps:

[0036] ①Add 3kgε-caprolactone, 1kg polyethylene glycol and 0.01kg stannous octoate to the reaction bottle to dissolve in the solvent, blow nitrogen gas, stir and react at 125°C for 8 hours to obtain a reaction solution, and dissolve the reaction solution in water , dialyzed for 2 days, and the dialysate was freeze-dried to obtain polycaprolactone-polyethylene glycol copolymer;

[0037] ② Take 1.5kg of polycaprolactone-polyethylene glycol copolymer obtained in step ① and dissolve it in an organic solvent, add 0.3kg of triethylamine and 0.3kg of acryloyl chloride at 0°C, raise ...

Embodiment 2

[0040] A nano-silica / polymer material guided bone regeneration composite porous film, the thickness is 0.3mm, the mass ratio of nano-silica and polymer material is 1:4; the polymer material is polycaprolactone and poly Lactic acid is composed according to the mass ratio of 1:3.

Embodiment 3

[0042] A nano-silica / polymer material guided bone regeneration composite porous film, with a thickness of 0.15 mm, and a mass ratio of nano-silica to polymer material of 1:2.5; the polymer material is polylactic acid and collagen by mass The ratio is 1:1.5.

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Abstract

The invention discloses a nano silicon dioxide / polymer material guided bone regeneration composite porous membrane and a preparation method thereof. The thickness of the membrane is 0.1-0.3 mm, the mass ratio of nano-silicon dioxide to a polymer material is 1:(2-4), and the polymer material is one or two of a poly(N-isopropyl acrylamide)-polycaprolactone-polyethylene glycol copolymer, polycaprolactone, polylactic acid, polyglycollide and collagen. The nano silicon dioxide / polymer material guided bone regeneration composite porous membrane is high in mechanical strength, good in biocompatibility, moderate in degradation speed and capable of achieving a good physical barrier effect, quickly growing fibroblasts are prevented from migrating to a wound part, a regeneration space is provided forslowly growing bone tissue, and the guided bone regeneration composite porous membrane has wide application prospects.

Description

technical field [0001] The invention relates to the technical field of guided bone regeneration membranes, in particular to a composite porous membrane of nano silicon dioxide / macromolecule material guided bone regeneration and a preparation method thereof. Background technique [0002] Guided Bone Regeneration GBR is a common treatment method for the treatment of alveolar bone or mandibular bone lesions caused by infection or trauma. The guided bone regeneration membrane is to create an isolated space at the wound site, which is conducive to the proliferation of bone cells and promote new bone formation. The guided bone regeneration membrane acts as a physical barrier, preventing the migration of fast-growing fibroblasts to the wound site and providing space for the slow-growing bone tissue to regenerate. The guided bone regeneration membrane needs to have good biodegradability and absorbability, high strength and high cell adhesion, but the guided bone regeneration membra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/56A61L27/58
CPCA61L27/446A61L27/56A61L27/58A61L2430/02
Inventor 仲学雷金桥赵运超
Owner 青岛杰圣博生物科技有限公司
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