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A kind of cellulose/n-isopropylacrylamide drug controlled release hydrogel and preparation method thereof

An isopropylacrylamide and hydrogel technology, which is applied in the directions of pharmaceutical formulations, photosplitting of drugs in vivo, and medical preparations with non-active ingredients, etc., to achieve simple and easy modification operation, improve mechanical properties and performance excellent effect

Active Publication Date: 2022-06-17
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the controlled release of drugs from cellulose hydrogels with both near-infrared responsiveness and temperature-sensitive properties under the "on-off" state of external infrared light

Method used

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  • A kind of cellulose/n-isopropylacrylamide drug controlled release hydrogel and preparation method thereof
  • A kind of cellulose/n-isopropylacrylamide drug controlled release hydrogel and preparation method thereof
  • A kind of cellulose/n-isopropylacrylamide drug controlled release hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) According to the mass ratio of cellulose raw material to sulfuric acid of 1:50, the cotton fiber raw material was added to a 50 wt% sulfuric acid solution, and the nanocellulose was obtained by ultrasonicating for 3 hours at a temperature of 60 °C, and the obtained nanocellulose was dialyzed. Then the nanocellulose solution is obtained;

[0028] (2) Dissolve 2.0 g of dopamine hydrochloride in 20 g of the nanocellulose suspension with a mass fraction of 10.0% obtained in step (1), adjust pH=8.5 with hydrochloric acid, and react at room temperature for 24 h. After that, an appropriate amount of deionized water was added to the nanocellulose to prepare a nanocellulose solution with a mass fraction of 8.0%.

[0029] (3) Take 0.4g of N-isopropylacrylamide and add it to 0.12g of the cellulose aqueous solution obtained in step (2), then add 0.004g of N,N'-methylenebisacrylamide cross-linking agent, magnetic force After stirring for 30-40min, the near-infrared responsive cel...

Embodiment 2

[0033] (1) According to the mass ratio of cellulose raw material to sulfuric acid of 1:50, the straw pulp fiber raw material was added to a 50 wt % sulfuric acid solution, and the nanocellulose was obtained by ultrasonicating for 3 hours at a temperature of 60 °C. After dialysis, a nanocellulose solution was obtained;

[0034] (2) Dissolve 2.0 g of dopamine hydrochloride in 20 g of the nanocellulose suspension with a mass fraction of 10.0% obtained in step (1), adjust pH=8.5 with hydrochloric acid, and react at room temperature for 24 h. After that, an appropriate amount of deionized water was added to the nanocellulose to prepare a nanocellulose solution with a mass fraction of 8.0%.

[0035] (3) Add 0.4 g of N-isopropylacrylamide to 0.4 g of the cellulose solution obtained in step (2), and then add 0.004 g of N,N'-methylenebisacrylamide cross-linking agent, Magnetic stirring for 30-40min, the near-infrared responsive cellulose / N-isopropylacrylamide hydrogel can be obtained ...

Embodiment 3

[0039] (1) According to the mass ratio of cellulose raw material to sulfuric acid of 1:50, add microcrystalline cellulose raw material to 50 wt % sulfuric acid solution, and ultrasonically obtain nanocellulose for 3 hours at a temperature of 60 °C. After dialysis, the nanocellulose solution was obtained;

[0040] (2) Dissolve 2.0 g of dopamine hydrochloride in 20 g of the nanocellulose suspension with a mass fraction of 10.0% obtained in step (1), adjust pH=8.5 with hydrochloric acid, and react at room temperature for 24 h. After that, an appropriate amount of deionized water was added to the nanocellulose to prepare a nanocellulose solution with a mass fraction of 8.0%.

[0041] (3) Take 0.4g of N-isopropylacrylamide and add it to 0.8g of the cellulose solution obtained in step (2), then add 0.004g of N,N'-methylenebisacrylamide cross-linking agent, magnetically After stirring for 30-40min, the near-infrared responsive cellulose / N-isopropylacrylamide hydrogel can be obtained...

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Abstract

The invention belongs to the technical field of cellulose hydrogel, and in particular relates to a cellulose / N-isopropylacrylamide drug-controlled release hydrogel and a preparation method thereof. Dopamine is added to the cellulose solution to modify the surface of the cellulose so that it can be wrapped on the macromolecular skeleton of the cellulose, so that the cellulose not only enhances the mechanical force, but also has the characteristics of light response. At the same time, N-isopropylacrylamide is dispersed into the modified cellulose solution, and a hydrogel is formed by free radical solution polymerization, thereby endowing the cellulose hydrogel with near-infrared responsiveness and temperature sensitivity. The nanocomposite hydrogel has certain potential application value in drug intelligent controlled release materials and biomedical fields.

Description

technical field [0001] The invention belongs to the technical field of cellulose hydrogels, in particular to a cellulose / N-isopropylacrylamide drug controllable release hydrogel and a preparation method thereof. Background technique [0002] Near-infrared responsive hydrogels are a kind of inorganic / organic functional composite materials that have the properties of near-infrared responsive materials, polymer materials and hydrogels at the same time. Due to its excellent near-infrared properties and biocompatibility, it has broad application prospects in the field of drug controlled release. Among them, the macromolecules of synthetic hydrogels include natural macromolecules and synthetic macromolecules. Natural macromolecules have attracted widespread attention due to their advantages of wide sources, low price, good biocompatibility and biodegradability. [0003] Dopamine is a biomolecule with catechol and amine functional groups. Its properties are similar to the strong a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/38A61K47/32A61K47/34A61K31/513A61K41/00C08F220/54C08F222/38C08B15/06
CPCA61K9/06A61K47/38A61K47/32A61K47/34A61K31/513A61K41/0042C08F220/54C08B15/06C08F222/385
Inventor 卢贝丽武羽岩林强林凤采黄彪刘杏王梓熊明诚邓秀春
Owner FUJIAN AGRI & FORESTRY UNIV
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