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A temperature-sensitive high-strength tissue adhesive

A tissue adhesive, high-strength technology, used in the field of tissue adhesives, which can solve problems such as insufficient force, limited adhesive use, and long duration

Active Publication Date: 2020-06-02
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems with this type of adhesive. First of all, compared with Mfps, mussel biomimetic adhesive has insufficient force between the liquid environment and the damaged tissue, and its structure needs to be further optimized to improve its adhesion. Force (Stewart RJ, Ransom TC, Hlady V.Natural underwater adhesives.Journal of Polymer Science.2011; 49(11), 757-771); secondly, the liquid adhesive needs to be cured to improve the strength after use, and the existing such The adhesive curing method is a response to time. It can only make the adhesive cure within a rough time range and the curing process lasts for a long time. make the use of such adhesives limited

Method used

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  • A temperature-sensitive high-strength tissue adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A temperature-sensitive high-strength tissue adhesive, its components and mass ratio are:

[0039] 85 parts of bionic adhesive, 15 parts of thermosensitive micelles loaded with oxidant, 20 parts of sodium polyacrylate gel;

[0040] The biomimetic adhesive in this example is prepared by the following method: dopamine methacrylamide and methoxyethyl acrylate are prepared by copolymerization reaction initiated by azobisisobutyronitrile at 60°C at a molar ratio of 1:13.

[0041] The temperature-sensitive micelles used in this example were prepared by the following method: polyethylene glycol, 1,3-bis(carboxyphenoxy)propane and sebacic acid were dissolved in n-hexane at a ratio of 1:1:1 Prepared by copolymerization reaction at 160°C and under the protection of nitrogen.

[0042] The oxidizing agent in the thermosensitive micelles that this example uses is sodium periodate (NaIO 4 ).

[0043] The temperature-sensitive micelles loaded with oxidizing agent in this example ar...

Embodiment 2

[0048] A temperature-sensitive high-strength tissue adhesive, its components and mass ratio are:

[0049] 75 parts of bionic adhesive, 25 parts of thermosensitive micelles loaded with oxidant, 15 parts of sodium polyacrylate gel;

[0050] The biomimetic adhesive in this example is prepared by the following method: dopamine methacrylamide and methoxyethyl acrylate are prepared by copolymerization reaction initiated by azobisisobutyronitrile at 60°C at a molar ratio of 1:13.

[0051] The temperature-sensitive micelles used in this example were prepared by the following method: dissolving polyethylene glycol, 1,3-bis(carboxyphenoxy)propane and sebacic acid in n-hexane at a ratio of 1:1.2:1.1 Prepared by copolymerization reaction at 160°C and under the protection of nitrogen.

[0052] The oxidizing agent in the thermosensitive micelles that this example uses is sodium periodate (NaIO 4 ).

[0053] The temperature-sensitive micelles loaded with oxidizing agent in this example ar...

Embodiment 3

[0057] A temperature-sensitive high-strength tissue adhesive, its components and mass ratio are:

[0058] 90 parts of bionic adhesive, 10 parts of thermosensitive micelles loaded with oxidant, 25 parts of sodium polyacrylate gel;

[0059] The biomimetic adhesive in this example is prepared by the following method: dopamine methacrylamide and methoxyethyl acrylate are prepared by copolymerization reaction initiated by azobisisobutyronitrile at 60°C at a molar ratio of 1:13.

[0060] The temperature-sensitive micelles used in this example were prepared by the following method: polyethylene glycol, 1,3-bis(carboxyphenoxy)propane and sebacic acid were dissolved in n-hexane at a ratio of 1:1:1 Prepared by copolymerization reaction at 160°C and under the protection of nitrogen.

[0061] The oxidant in the thermosensitive micelles used in this example is hydrogen peroxide (H 2 o 2 ).

[0062] The temperature-sensitive micelles loaded with oxidizing agent in this example are prepa...

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Abstract

The invention belongs to the technical field of tissue adhesives and particularly relates to a thermo-sensitive-type high-strength tissue adhesive. The problems are solved that in the prior art, the curing time of the tissue adhesive is long, and it is difficult to accurately control the curing time. According to the technical scheme, the tissue adhesive is prepared from, by weight, 75-90 parts ofa bionic adhesive and 10-25 parts of a thermo-sensitive micelle carried with an oxidizing agent. The bionic adhesive is prepared through copolymerization of dopamine methacrylamide and acrylic acid methoxyethyl ethyl ester, and the thermo-sensitive micelle is prepared through copolymerization of polyethylene glycol, 1,3-bis(carboxyl phenoxyl)propane and sebacic acid. An application method of thethermo-sensitive-type high-strength tissue adhesive comprises the steps that the injured part is coated or injected with the tissue adhesive, after being restored and fixed, the injured part is gluedthrough the adhesive, then the injured part is subjected to hot compress in a short time (3-5 minutes), the thermo-sensitive micelle is heated and instantly acutely releases an oxidizing agent for triggering cross-linking curing of the adhesive, and the tissue repairing operation can be completed.

Description

technical field [0001] The invention belongs to the technical field of tissue adhesives, in particular to a temperature-sensitive high-strength tissue adhesive. Background technique [0002] Human tissue can self-repair some soft and hard tissue wounds that are close to each other and relatively fixed in position. When repairing damaged tissue clinically, it is first necessary to fix the damaged wound and keep the wound tissue close and relatively fixed. When dealing with large damaged tissue, traditional methods of mechanical fixation are usually used, such as fixing with sutures or rivets. The location of the tissue thereby facilitates tissue recovery. However, the effect of the above methods is not satisfactory, because the sutures, rivets and other fixing materials used in the suturing or staple operation do not have more complicated functions (such as sealing, anti-inflammatory, analgesic, etc.) except for the fixing effect; Stitches can cause bleeding or damage to su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61L24/00C08F220/28C08F220/60
CPCA61L24/001A61L24/0015A61L24/043A61L2400/04A61L2400/06C08F220/28C08F220/281C08L33/14C08L71/02C08L33/02C08F220/60
Inventor 熊雄屈树新张纯姑单连海
Owner SOUTHWEST JIAOTONG UNIV