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Antioxidant Ce-doped CQDs (carbon quantum dots) as well as preparation method and application thereof

A technology of carbon quantum dots and cerium doping, applied in the field of nanomaterials and medical engineering, can solve the problems of lack of research reports, achieve broad application prospects, improve fluorescence quantum yield, and have low biological toxicity

Active Publication Date: 2019-07-12
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although cerium oxide can play a role in a series of biological processes through its ability to scavenge free radicals, so far, there is still a lack of research reports on the preparation and application of cerium-doped carbon quantum dots.

Method used

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  • Antioxidant Ce-doped CQDs (carbon quantum dots) as well as preparation method and application thereof
  • Antioxidant Ce-doped CQDs (carbon quantum dots) as well as preparation method and application thereof
  • Antioxidant Ce-doped CQDs (carbon quantum dots) as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] In this example, cerium-doped carbon quantum dots were prepared by the following steps:

[0028] Dissolve 0.60 g of glycine, 0.84 g of citric acid, and 0.10 g of cerium nitrate hexahydrate in 20 mL of double-distilled water, and stir magnetically at room temperature to fully dissolve to obtain a uniform and transparent solution. Put the above solution into the reaction kettle to seal it, put it into an electric constant temperature vacuum oven, heat at 160°C for 4 hours, cool to room temperature to obtain a quantum dot solution, and centrifuge at 2000 rpm for 15 minutes to remove large particle precipitates. The collected supernatant was poured into a dialysis bag with a molecular cut-off of 1000 Da for dialysis. The dialysis time was 72 h, and the water was changed every 12 h. The dialysis product was freeze-dried in a freeze dryer at -80°C to a powder form to obtain cerium-doped carbon quantum dots.

Embodiment 2

[0030] Dissolve 0.75 g of glycine, 0.84 g of citric acid, and 0.10 g of cerium nitrate hexahydrate in 20 mL of double-distilled water, and stir magnetically at room temperature to fully dissolve to obtain a uniform and transparent solution. Put the above solution into the reaction kettle to seal it, put it into an electric constant temperature vacuum oven, heat at 200°C for 3 hours, cool to room temperature to obtain a quantum dot solution, and centrifuge at 2000 rpm for 15 minutes to remove large particle precipitates. The collected supernatant was injected into a dialysis bag with a molecular cut-off of 2000 Da for dialysis. The dialysis time was 72 h, and the water was changed every 12 h. The dialysis product was freeze-dried in a freeze dryer at -80 °C to powder to obtain cerium-doped carbon quantum dots.

Embodiment 3

[0032] Dissolve 0.90 g of glycine, 0.84 g of citric acid, and 0.10 g of cerium nitrate hexahydrate in 20 mL of double-distilled water, and stir magnetically at room temperature to fully dissolve to obtain a uniform and transparent solution. Put the above solution into the reaction kettle to seal it, put it into an electric constant temperature vacuum oven, heat at 200°C for 7 hours, cool to room temperature to obtain a quantum dot solution, and centrifuge at 2000 rpm for 15 minutes to remove large particle precipitates. The collected supernatant was injected into a dialysis bag with a molecular cut-off of 2000 Da for dialysis. The dialysis time was 72 h, and the water was changed every 12 h. The dialysis product was freeze-dried in a freeze dryer at -80 °C to powder to obtain cerium-doped carbon quantum dots.

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Abstract

The invention belongs to the field of nanomaterials and medical engineering and relates to antioxidant Ce-doped CQDs (carbon quantum dots) as well as a preparation method and an application thereof. Glycine is taken as a surface passivator, citric acid is taken as a carbon source material, cerium nitrate provides a cerium element, residues and water are removed through dialysis and freeze drying with a one-step hydrothermal carbonization method, and the Ce-doped CQDs are obtained. The prepared Ce-doped CQDs have excellent characteristics of a higher fluorescence property, better antioxidant effects and good biocompatibility and the like, are successfully applied to antioxidant experiments of in-vitro live cells and have broad application prospects in the field of biomedicine. The providedpreparation method has the characteristics of being simple in process, low in cost and prone to mass production.

Description

technical field [0001] The invention belongs to the field of nanomaterials and medical engineering, and relates to an oxidation-resistant cerium-doped carbon quantum dot and its preparation method and application. Background technique [0002] Cerium (Ce) is an element in the periodic table of rare earth elements, due to its lack of electronic structure from Ce 3+ A single electron in the middle 4f orbital, Ce usually exists in a tetravalent and more stable state. Nevertheless, CeO 2 exhibit more typical properties at the nanoscale. Due to the many cubic spaces in the fluorite structure, cerium ions have the ability to reversibly switch between trivalent and tetravalent. In recent years, due to CeO 2 The regenerative properties and anti-oxidation properties of nanomaterials are considered to be ideal anti-oxidation materials and have broad application prospects in nanomedicine. It is because of Ce 3+ / Ce 4+ Lower reduction potential, CeO 2 can scavenge oxygen free r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y30/00B82Y40/00A61K33/24A61K33/44A61P39/06
CPCC09K11/7715B82Y20/00B82Y30/00B82Y40/00A61K33/244A61K49/0067A61K49/0019A61P39/06
Inventor 杜凤移赵璐璐杜凤亭张苗苗蔡茸邹圣强吴云超
Owner JIANGSU UNIV
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