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Application of chicoric acid, echinacea extract and corresponding preparations to preparing lead toxicity reducing drugs

A technology of Echinacea purpurea extract and cichoric acid, which can be used in drug combinations, anti-toxins, and pharmaceutical formulas. It can solve problems such as neurodevelopmental disorders, difficult to eliminate lead, and hypocalcemia, and achieve high drug loading and relieve heavy metals. Toxicity, high bioavailability effect

Active Publication Date: 2019-07-26
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, their use can cause serious side effects, including dehydration, low blood calcium, and kidney damage
There may also be more serious problems such as hypocalcemia, neurodevelopmental impairment, and even death (Guido Crisponi et.al., Coordination Chemistry Reviews, 2015; Mj ​​Kosnett, Clinical Pharmacology & Therapeutics, 2010)
And for long-term exposure to low levels of lead, chelation therapy is generally of limited value (Pamela A. Meyer et.al., Mutation Research, 2008)
In addition, lead is also difficult to completely eliminate from the body (Cássia Regina Bruno Nascimento et.al., Environmental Toxicology and Pharmacology, 2016)

Method used

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  • Application of chicoric acid, echinacea extract and corresponding preparations to preparing lead toxicity reducing drugs
  • Application of chicoric acid, echinacea extract and corresponding preparations to preparing lead toxicity reducing drugs
  • Application of chicoric acid, echinacea extract and corresponding preparations to preparing lead toxicity reducing drugs

Examples

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preparation example Construction

[0072] Further, the present invention provides a method for preparing the solid lipid microspheres of the above-mentioned Echinacea purpurea extract, comprising the following steps:

[0073] Step 1, respectively weigh the extract of Echinacea purpurea, soybean lecithin and stearic acid according to the weight ratio, heat and melt, and stir evenly;

[0074] Step 2, adding glycerin and poloxamer 188 aqueous solution at the same temperature to the reaction system in step 1 to prepare colostrum;

[0075] Step 3, the colostrum is subjected to high-pressure emulsification treatment, and then rapidly cooled to form a solid lipid microsphere suspension;

[0076] Step 4, freeze-drying to obtain the solid lipid microspheres of the Echinacea purpurea extract.

[0077] In the present invention, in step 1, the heating temperature is 70-80°C.

[0078] In the present invention, in step 2, the total concentration of glycerol and poloxamer 188 in the aqueous solution is 10wt%-15wt%.

[0079...

Embodiment 1

[0113] (1) The raw material of Echinacea purpurea extract solid lipid microspheres in the present embodiment comprises the following components by weight ratio:

[0114]

[0115]

[0116] (2) Preparation method

[0117] Weigh 50g of Echinacea purpurea extract, 110g of soybean lecithin and 54g of stearic acid, heat to melt at 75°C under nitrogen, and stir evenly;

[0118] Add an aqueous solution prepared by adding 18 g of glycerin and 30 g of poloxamer 188 at the same temperature to the above reaction system to prepare colostrum; the total concentration of glycerin and poloxamer 188 in the aqueous solution is 10 wt %;

[0119] The colostrum was emulsified under high pressure at 40 MPa for 5 times under the condition of nitrogen, and then cooled rapidly to form a suspension of solid lipid microspheres; freeze-dried at -20°C and 10 Pa for 60 hours to obtain freeze-dried Echinacea purpurea Extract solid lipid microspheres.

Embodiment 2

[0121] In this embodiment, the solid lipid microspheres and the method used are similar to those in Example 1, the only difference being that the raw materials of the Echinacea purpurea extract solid lipid microspheres include the following components by weight:

[0122]

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PUM

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Abstract

The invention discloses application of chicoric acid, an echinacea extract and corresponding preparations to preparing lead toxicity reducing drugs. The echinacea extract is discovered for the first time to be capable of reducing heavy metal toxicity, effectively relieve cytotoxic and inflammatory reactions caused by lead ions to neurogliocytes and reduce the lead ion-caused death rate and malformation rate of young zebra fish. The application of the chicoric acid, the echinacea extract and the corresponding preparations to preparing the lead toxicity reducing drugs can provide new approachesand new drug candidates for lead poisoning treatment.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and specifically relates to an extract of Echinacea purpurea, a preparation, a corresponding preparation method, and the use of cichoric acid or the extract of Echinacea purpurea and the corresponding preparation for preparing medicines for alleviating lead toxicity. Background technique [0002] In 2017, a total of more than 4 million tons of lead metal was produced globally, and a large amount of lead has entered the environment through electronic waste, low-quality fuel or used batteries (Joyce A Ober, US Geological Survey, 2018). Lead can enter the body through ingestion of contaminated food or inhalation of PM2.5 particles and cause serious health problems, including liver damage, central nervous system damage, and inflammation (Monica Shirley Mani et.al., Toxicology Letters, 2018; Abjal Pasha Shaik et. al., Journal of Hazardous Materials, 2009). Most seriously, lead can cause irreversible...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/16A61K47/10A61K47/24A61K47/12A61P39/02
CPCA61K9/1617A61K9/1641A61K36/28A61P39/02
Inventor 穆岩王晓王岱杰纪文华于金倩刘伟
Owner SHANDONG ANALYSIS & TEST CENT
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