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Preparation method of high-purity sodium pantothenate

A sodium pantothenate, high-purity technology, applied in the field of medicine, can solve the problems of difficulty, harsh conditions, and long crystal growth time, and achieve the effects of uniform particle size, simple operation and good fluidity

Active Publication Date: 2019-08-09
珠海润都制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The preparation method of sodium pantothenate is mentioned in Chinese patent CN 103145579A: buy commercially available crude sodium pantothenate, dissolve in water, concentrate, decolorize, add a mixed solution of ethanol and ether, cool down and grow crystals in an ultrasonic field for 6 to 12 hours, filter Sodium pantothenate crude drug is obtained. This method is actually a refining method of sodium pantothenate, and requires crystallization and crystallization under an ultrasonic field. The conditions are harsh, the crystallization time is long, labor-consuming, and ether solvents are used, which is dangerous and unsafe. Suitable for industrial production
[0007] Chinese patent CN109280015A uses methanol or ethanol of β-alanine to add sodium methoxide, cools down and adds DL-pantoate lactone, induces resolution, and obtains D-sodium pantothenate with a final yield of about 45%, which is not suitable for industrial production
[0009] Obtaining pure forms of vitamins is tedious and difficult due to the highly lyophilized nature of vitamins, and in these products the purity cannot be They absorb water and thicken when exposed to humidity, making the handling of pantothenic acid formulations a considerable problem

Method used

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  • Preparation method of high-purity sodium pantothenate

Examples

Experimental program
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Effect test

Embodiment 1

[0032] (1) Preparation of sodium β-alanine

[0033] Add 90kg of isopropanol, 20kg of β-alanine, and 9kg of sodium hydroxide into a 200L reaction tank, heat to 60±5°C, and stir for 1-3h. Stop heating, lower the temperature to 5-15°C, stir and crystallize for 3h. Put the material in the tank into the centrifuge for centrifugation, collect the filter cake to obtain sodium β-alanine (wet product), dry the wet product at a temperature of 85±5°C for 12 hours, collect the material after cooling to room temperature, take a sample and weigh it , to obtain β-alanine sodium with a yield of 95%.

[0034] (2) Preparation of sodium pantothenate (crude product)

[0035] Add isopropanol (11.2 times the weight of sodium β-alanine) to the 500L reaction tank, start stirring, add D-pantoate lactone (1.17 times the weight of sodium β-alanine), add β-propanol Sodium amino acid (full amount in the previous process), heating, temperature control 65±5°C, and reacting for 5 hours. Stop heating, coo...

Embodiment 2

[0039] (1) Preparation of sodium β-alanine

[0040] Add 90g of anhydrous methanol, 20g of β-alanine, and 9g of sodium hydroxide into a 250ml flask, heat to 62°C, stir for 3h, stop heating, cool down to 10°C, stir for 3h to crystallize, no crystals precipitate.

Embodiment 3

[0042] (1) Preparation of sodium β-alanine

[0043] Add 90g of absolute ethanol, 20g of β-alanine, and 9g of sodium hydroxide into a 250ml flask, heat to 62°C, stir for 3h, stop heating, cool down to 10°C, stir for 3h to crystallize, no crystals precipitate.

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Abstract

The invention discloses a preparation method of high-purity sodium pantoate. According to the method, beta-alanine and an alkali are adopted as raw materials for a reaction in a low-level alkanol solvent to obtain sodium beta-alaninate, the sodium beta-alaninate reacts with D-pantolactone in a low-level alkanol solvent to obtain a crude sodium pantothenate product, and the crude sodium pantothenate product is refined in 95% ethanol and crystallized to obtain sodium pantothenate. Sodium pantoate prepared by means of the method has the advantages that being uniform in particle size, good in fluidity, low in wettability, easy to operate, environmentally friendly, high in yield and purity and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of high-purity sodium pantothenate. Background technique [0002] Pantothenic acid is a B vitamin substance, a kind of water-soluble vitamin, widely exists in the biological world, commonly known as vitamin B, can be divided into DL-type (mixed body), D-type (dextral body), L-type (left-handed body), only the D-type body (dextral body) has biological activity, commonly used pantothenic acid as calcium salt or sodium salt, widely used in medicine, feed, food and other industries, D-sodium pantothenic acid is the D-type of pantothenic acid The sodium salt of enantiomers, because pantothenic acid often needs to be used in combination with other B vitamins such as riboflavin sodium phosphate, will form calcium phosphate to reduce the potency of the drug and cause incompatibility, which can be avoided by using sodium pantothenic acid to achieve safe a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C235/12C07C231/24C07C231/02
CPCC07C227/18C07C231/02C07C231/24C07C229/08C07C235/12
Inventor 刘杰覃志俊郭锐庞振坤蔡强兰柳琴
Owner 珠海润都制药股份有限公司
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