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Domperidone orally disintegrating tablet and preparing method thereof

A technology for oral disintegrating tablets and domperidone, which is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of gritty feeling, large difference in tablet weight, sticking and flushing, etc., To achieve the effect of improving fluidity, quality assurance, and improving sticking and punching

Active Publication Date: 2019-08-23
广东人人康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The orally disintegrating tablet of domperidone is easy to use, melts in the mouth, can be swallowed without water, and can be mostly dissolved after encountering saliva in the oral cavity, and can be absorbed quickly after taking it. Rush, one side is not smooth, the weight of the tablet varies greatly, and there is a feeling of sand when taking it

Method used

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  • Domperidone orally disintegrating tablet and preparing method thereof
  • Domperidone orally disintegrating tablet and preparing method thereof
  • Domperidone orally disintegrating tablet and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] An embodiment of the domperidone orally disintegrating tablet of the present invention comprises the following components by weight: 10 parts by weight of domperidone, 80 parts by weight of filler, 10 parts by weight of disintegrant, 5 parts by weight of sweetener, flow aid 2.1 parts by weight of agent, 0.54 parts by weight of lubricant. The filler is microcrystalline cellulose, the disintegrant is croscarmellose sodium, the sweetener is aspartame, and the glidant is silicon dioxide. Described lubricant is the mixture of magnesium stearate, glyceryl behenate, sodium stearyl fumarate, and the weight ratio of described magnesium stearate, glyceryl behenate, sodium stearyl fumarate is 3: 1:2.

[0024] The preparation method of above-mentioned domperidone orally disintegrating tablet, comprises the following steps:

[0025] (1) After pulverizing the domperidone, filler, disintegrant, sweetener and glidant respectively, pass through a 100-mesh sieve respectively;

[0026]...

Embodiment 2

[0030] An embodiment of the domperidone orally disintegrating tablet of the present invention comprises the following components by weight: 10 parts by weight of domperidone, 80 parts by weight of filler, 10 parts by weight of disintegrant, 5 parts by weight of sweetener, flow aid 2.1 parts by weight of agent, 0.54 parts by weight of lubricant. The filler is microcrystalline cellulose, the disintegrant is croscarmellose sodium, the sweetener is aspartame, and the glidant is silicon dioxide. Described lubricant is the mixture of magnesium stearate, glyceryl behenate, sodium stearyl fumarate, and the weight ratio of described magnesium stearate, glyceryl behenate, sodium stearyl fumarate is 1: 1:4.

[0031] The preparation method of above-mentioned domperidone orally disintegrating tablet, comprises the following steps:

[0032] (1) After pulverizing the domperidone, filler, disintegrant, sweetener and glidant respectively, pass through a 100-mesh sieve respectively;

[0033]...

Embodiment 3

[0037] An embodiment of the domperidone orally disintegrating tablet of the present invention comprises the following components by weight: 10 parts by weight of domperidone, 80 parts by weight of filler, 10 parts by weight of disintegrant, 5 parts by weight of sweetener, flow aid 2.1 parts by weight of agent, 0.54 parts by weight of lubricant. The filler is microcrystalline cellulose, the disintegrant is croscarmellose sodium, the sweetener is aspartame, and the glidant is silicon dioxide. Described lubricant is the mixture of magnesium stearate, glyceryl behenate, sodium stearyl fumarate, and the weight ratio of described magnesium stearate, glyceryl behenate, sodium stearyl fumarate is 1: 5:2.

[0038] The preparation method of above-mentioned domperidone orally disintegrating tablet, comprises the following steps:

[0039] (1) After pulverizing the domperidone, filler, disintegrant, sweetener and glidant respectively, pass through a 100-mesh sieve respectively;

[0040]...

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Abstract

The invention provides a domperidone orally disintegrating tablet. The domperidone orally disintegrating tablet is prepared from, by weight, 6-12 parts of domperidone, 70-90 parts of a filling agent,5-12 parts of a disintegrating agent, 1-6 parts of a sweetening agent, 1-3 parts of a flow aid and 0.1-1 part of a lubricating agent. According to the domperidone orally disintegrating tablet, a formula and the preparing technology are improved, and thus the liquidity of tabletting materials is improved; according to monitoring data of the surface smoothness, the taste, the tablet weight difference and the dissolution rate of the tablet, it is shown that after the technology is improved, the domperidone orally disintegrating tablet meets stipulation or is better, the problems of sticking, an unsmoothed tablet surface, a large tablet weight difference, an unsmoothed taste and the like appearing in the tabletting process are solved, the product meets the quality standard requirement, and thequality is guaranteed.

Description

technical field [0001] The invention relates to a domperidone orally disintegrating tablet and a preparation method thereof. Background technique [0002] Domperidone is a peripheral dopamine receptor antagonist with a strong effect. It acts directly on the gastrointestinal wall, which can moderately increase the tension of the lower esophageal sphincter and prevent gastroesophageal reflux; enhance tail motility, promote gastric emptying, and improve gastric and esophageal reflux. Motility coordination of the duodenum, prevention of bile reflux, regulation and restoration of motility in the upper gastrointestinal tract; inhibition of nausea, vomiting. It is clinically used for indigestion accompanied by slow gastric emptying and esophageal reflux, such as lower abdomen or abdominal fullness, flatulence, nausea and vomiting after meals. It can also be used for nausea and vomiting caused by drugs and amine radiation therapy, vomiting after surgery, cerebral energy (such as py...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/454A61K47/12A61K47/14A61P1/14A61P1/08A61P1/04
CPCA61K9/0056A61K9/2013A61K9/2095A61K31/454A61P1/04A61P1/08A61P1/14
Inventor 陈友鸿房志宜朱琳赵盛涛袁媛林美艳黎全陈洋舟农柳玲李秋兰宋娇甘燕珍
Owner 广东人人康药业有限公司
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