Application of bighead atractylodes rhizome essential oil

A technology of Atractylodes macrocephala and essential oil, applied in the field of biomedicine, to achieve the effect of improving biological activity, long half-life, and small side effects

Inactive Publication Date: 2019-08-23
东莞怀朴植物精油有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previously, this pharmacological effect has not been reported

Method used

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  • Application of bighead atractylodes rhizome essential oil
  • Application of bighead atractylodes rhizome essential oil
  • Application of bighead atractylodes rhizome essential oil

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preparation example Construction

[0041] The preparation method of the Atractylodes macrocephala essential oil of the present invention comprises steam distillation extraction and carbon dioxide supercritical extraction.

[0042] The Atractylodes Rhizome essential oil of the present invention is detected by gas chromatography-mass spectrometry, and its component ratios are atractylol (>60%), germacrene B (germacrene B) (>9%) in terms of mass percentage, L-alloaromadendrene (>6%), β-eudesmene (>2%).

Embodiment 1

[0044] Get 100Kg of fresh or dry roots, stems or leaves of Atractylodes macrocephala Koidz., pile them up for 2 days, grind them to 50 mesh coarse particles, soak the coarse particles in 8 mass times the amount of pH value of 5.0 hydrochloric acid aqueous solution, soak Put it up overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer was dried with anhydrous sodium sulfate and separated to obtain Atractylodes macrocephala essential oil.

Embodiment 2

[0046] Get 50Kg of fresh or dry roots, stems or leaves of Atractylodes macrocephala (Atractylodes macrocephala Koidz.), put them in a heap for 2 days, grind them to 50 mesh coarse particles, soak the coarse particles in 8 mass times the amount of pH value of 5.0 hydrochloric acid aqueous solution, soak Put it up overnight. 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixed solution into a carbon dioxide supercritical extraction instrument. The extraction temperature is 46°C, the pressure is 15.70MPa, the time is 85min, and the flow rate of carbon dioxide is 30kg / h; the essential oil is collected and refined in a molecular distillation instrument. The feed temperature was 43°C, the injection speed was 510mL / h, the first-stage evaporation temperature was 112°C, and the second-stage evaporation temperature was 63°C, and the fraction of the second-sta...

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Abstract

The invention discloses application of bighead atractylodes rhizome essential oil. The bighead atractylodes rhizome essential oil can be applied to preparation of medicines for treating or preventingbrain function and disorder diseases as well as healthy products for improving the brain function and disorder diseases. The invention discovers the new application of the bighead atractylodes rhizomeessential oil to preparation of medicine or large health products which show activity in the experiment animal brain function and disorder diseases for the first time; and the invention discovers that the bighead atractylodes rhizome essential oil or the composition containing the bighead atractylodes rhizome essential oil can improve the brain function and disorder animal symptoms such as seniledementia, depression and anxiety in an animal in vivo model for the first time. Compared with the medicines for treating the brain function and disorder thereof at present, the bighead atractylodes rhizome essential oil or the any composition has mechanism of performing multimolecular synergistic effect of inhibiting cholinesterase and regulating neurotransmitter on a multi-target point, has goodpharmacokinetic parameters and can penetrate through a blood brain barrier easily, so the characteristics of toxicological safety, metabolic stability, long half-life period and small side effect areachieved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of Atractylodes macrocephala essential oil in medicines and health products for treating and preventing brain function and its disorders. Background technique [0002] Compositae Atractylodes macrocephala Koidz (Atractylodes macrocephala Koidz.) is currently mainly cultivated in Zhejiang, Anhui and Hubei. The dried rhizome of Atractylodes macrocephala is a traditional Chinese medicinal material, which has been recorded in successive dynasties of herbal medicines. It has been recorded in the Pharmacopoeia of the People's Republic of China over the years that Atractylodes Rhizoma Atractylodes Rhizome has the effects of invigorating the spleen and replenishing qi, drying dampness and promoting diuresis, antiperspirant, and preventing miscarriage. For the treatment of spleen deficiency, lack of food, abdominal distension and diarrhea, phlegm and retention dizzine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/284A61P25/00A61P25/14A61P25/22A61P25/24A61P25/18A61P9/10A61P25/28A61P25/20A61P25/16A61K8/92A61Q19/00A61L9/013A61L101/56
CPCA61K8/922A61K36/284A61K2236/19A61K2236/331A61K2236/333A61K2800/10A61L9/013A61P9/10A61P25/00A61P25/14A61P25/16A61P25/18A61P25/20A61P25/22A61P25/24A61P25/28A61Q19/00
Inventor 许敏韩佳欣陈淑霞曹海龙罗道玉郑三会李云辉顾培爽宋晖
Owner 东莞怀朴植物精油有限公司
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