Glucosamine hydrochloride bone joint intelligent hydrogel, preparation method and use thereof

Abstract

The invention discloses a glucosamine hydrochloride bone joint intelligent hydrogel, a preparation method and use thereof. The intelligent hydrogel comprises: P407, P188, water, NaHSO3, NaHCO3 and glucosamine hydrochloride; wherein the mass fraction of the P407 is 20% to 24%, and the mass fraction of the P188 is 2% to 8%; the mass fraction of NaHSO3 is 1% to 2%; and the mass fraction of glucosamine hydrochloride is 3% to 8%; and the pH of the NaHCO3 is adjusted to 5-7. The intelligent hydrogel of the invention is locally administered through the joint cavity, so that the glucosamine is effectively targeted to the articular cartilage, the gelation transformation is achieved under the action of body temperature, the release time of glucosamine in the body is prolonged, the injection stimulation of a drug is reduced to reduce the irritation to the body, and the therapeutic effect on osteoarthritis can be achieved.

Description

technical field

[0001] The invention relates to an intelligent hydrogel, in particular to a glucosamine hydrochloride bone joint intelligent hydrogel and its preparation method and application. Background technique

[0002] Osteoarthritis (OA) is a general term for bone and joint diseases. It is a chronic and progressive disease caused by trauma, congenital abnormalities of joints, joint deformities, cartilage rupture or destruction, etc. It is also a common disease in pet dogs. a joint disease. The pathogenesis of osteoarthritis is not yet clear, and many factors can induce its occurrence, so the treatment methods are also different.

[0003] The principle of osteoarthritis treatment is to relieve pain, control inflammation and promote cartilage healing, generally including physical therapy (exercise, weight loss, massage, etc.), drug therapy, surgical treatment, nutritional therapy, etc. In drug treatment, doctors often use anti-inflammatory drugs to achieve anti-inflamm...

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