Shampoo containing water-soluble cannabidiol and preparation method thereof

A cannabidiol, water-soluble technology, applied in the field of daily chemicals, can solve the problems of reducing the solubility of active ingredients, decreasing the bioavailability, not easily absorbed by the skin, etc., achieving good biodegradation performance, inhibiting bacterial growth, and improving water solubility. and its utilization effect

Inactive Publication Date: 2019-09-13
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since cannabidiol is a fat-soluble compound and is almost insoluble in water, and most of the shampoo formula is water, directly adding cannabis extract or cannabidiol to the shampoo formula will reduce the solubility of the active ingredients, making it difficult to Absorbed by the skin, resulting in greatly reduced bioavailability, unable to fully exert its efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Preparation of water-soluble cannabidiol

[0030] ① Accurately weigh 100g of cannabidiol solid powder (purity above 99%) and 500g of ethanol into a 1L single-necked round bottom flask; mechanically stir for 30 minutes to fully dissolve the cannabidiol solid; cool to room temperature after the dissolution is complete.

[0031] ② Accurately weigh 300g of α-cyclodextrin and 900g of primary purified water into a 2L single-necked round bottom flask, place the flask in a 40°C water bath, and stir mechanically for 30 minutes to fully dissolve the α-cyclodextrin in the water to form Transparent solution; after the dissolution is complete, add the solution described in step ① into it at one time, and continue to stir for 10 minutes.

[0032] ③Inclusion, put the mixture prepared in step ② into a high-pressure homogenizer, start the high-pressure pump, and homogenize 3 times at a pressure of 35MPa and a temperature of 25°C; after the high-pressure homogenization treatment, use...

Embodiment 2

[0040] (1) The preparation method of water-soluble cannabidiol is the same as in Example 1.

[0041] (2) A shampoo containing water-soluble cannabidiol and a preparation method thereof, comprising the following steps:

[0042] Step 1: Prepare 100 grams of product, weigh 40 grams of deionized water, 0.1 grams of EDTA-2Na, 1 gram of polyquaternium-10, and 0.5 grams of cationic guar gum and add them to the reactor, stir until completely dissolved, and obtain a solution a.

[0043] Step 2: Heat solution A to 75°C, add 10 grams of sodium lauroyl sarcosinate, 5 grams of sodium cocoamidopropionate, and 0.5 grams of ethylene glycol monostearate, and stir until completely dissolved to obtain solution B .

[0044] Step 3. After solution B cools down to 45°C, add 4 grams of water-soluble cannabidiol, 2 grams of sodium chloride, 0.5 grams of lavender essential oil, and 0.005 grams of phenoxyethanol in sequence. The pH was adjusted to 6.0.

[0045] Step 4, standing still for more than ...

Embodiment 3

[0047] (1) The preparation method of water-soluble cannabidiol is the same as in Example 1.

[0048] (2) A shampoo containing water-soluble cannabidiol and a preparation method thereof, comprising the following steps:

[0049] Step 1. Prepare 100 grams of product, weigh 40 grams of deionized water, 0.5 grams of EDTA-4Na, 2 grams of polyquaternium-52, and 2 grams of cationic guar gum into the reactor, stir until completely dissolved, and obtain a solution a.

[0050]Step 2. Heat solution A to 80°C, add 15 grams of sodium lauroyl glutamate, 5 grams of sodium methyl cocoyl taurate, 5 grams of sodium cocoamidopropionate, and 1 gram of ethylene glycol monohard Fatty acid ester, 1 ethylene glycol distearate, stirred until completely dissolved to obtain solution B.

[0051] Step 3. After solution B cools down to 40°C, add 3 grams of water-soluble cannabidiol, 1 gram of sodium chloride, 0.5 gram of jasmine essential oil, and 0.01 gram of sodium benzoate in sequence. Adjust the valu...

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PUM

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Abstract

The invention discloses a shampoo containing water-soluble cannabidiol and a preparation method thereof. The shampoo includes water-soluble cannabidiol, a surfactant, a conditioning agent, a thickening agent, a pearling agent, a chelating agent, essence, a preservative and deionized water. The shampoo takes the water-soluble cannabidiol as a main functional component and is prepared through a special technology, so that the water-soluble problem of the cannabidiol can be solved, and the bioavailability of the cannabidiol can be greatly enhanced; through the addition of a proper amount of the water-soluble cannabidiol, the shampoo can have good antibiosis and anti-inflammation, anti-dandruff and itching relieving, and calming and soothing efficacy; and the shampoo does not contain siliconeoil, and the cannabidiol is a pure plant natural active component, so that the shampoo is healthy, safe, mild and non-irritant.

Description

technical field [0001] The invention belongs to the field of daily chemicals and relates to a shampoo, in particular to a shampoo containing water-soluble cannabidiol and a preparation method thereof. Background technique [0002] Shampoo is an indispensable daily necessities for people's daily life. With the improvement of living standards, people pay more and more attention to health and safety. In order to further meet the different needs of consumers and the development trend of product function diversification, based on shampoo Adding biologically active natural products to the formula is an important direction for the development of special functional products. [0003] Dandruff is caused by scalp dysfunction and is a product of metabolism. In recent years, studies have shown that excessive dandruff and scalp itching are closely related to the abnormal proliferation of Pityrosporum ovale. The generation of dandruff creates favorable conditions for the growth and repro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/73A61K8/44A61K8/42A61K8/46A61Q5/02A61Q5/00A61Q17/00A61Q5/12
CPCA61K8/347A61K8/42A61K8/44A61K8/466A61K8/738A61K2800/34A61K2800/56A61Q5/006A61Q5/02A61Q5/12A61Q17/005
Inventor 王钲霖刘胜贵薛红芬付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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