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Integrated colored optical 3D biological printing system based on image-forming principle

A technology of printing system and imaging principle, applied in the field of optical 3D bioprinting system, can solve the problems of inability to realize mixed processing of various materials, inability to complete non-uniform mixed system molding, and low one-time use rate of material liquid, etc.

Active Publication Date: 2019-09-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The disadvantages of this biological tissue forming method are: 1. Whether it is DLP or extrusion, it is impossible to use multiple materials to cooperate to complete the forming task of a biological tissue, so it is impossible to realize the mixed processing of multiple materials.
The active organism is a heterogeneous mixed system containing multiple structures and various material components, and the above-mentioned method cannot complete the formation of the heterogeneous mixed system.
2. The feeding and molding speed of DLP is fast, but there is a lot of wasted material liquid, and the one-time use rate of material liquid is low

Method used

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  • Integrated colored optical 3D biological printing system based on image-forming principle
  • Integrated colored optical 3D biological printing system based on image-forming principle
  • Integrated colored optical 3D biological printing system based on image-forming principle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Example 1: Fast Batch Printing for 8-Color Microcubes

[0169] Bio-ink configuration: 1) 75 mg o-nitrobenzyl-modified hyaluronic acid (HA-NB), 250 mg methacrylic anhydride-modified gelatin (GelMA) and 10 mg phenyl (2,4,6-trimethyl Lithium benzoyl) phosphate (LAP) was dissolved in 10ml deionized water to prepare a light-controlled 3D printing ink containing 0.75% HA-NB, 2.5% GelMA and 0.1% LAP.

[0170] The structure of the printing device is as figure 1 As shown, the top view is on the left, and the three-dimensional view is on the right. There are 3 outlets A, B, and C, which respectively discharge different inks. The lifting platform is located above the printing pool, and the light is projected into the printing pool from below. When printing different materials Different inks can be conveniently removed, and the type of ink can be easily replaced without causing pollution between inks. Make the printed material more accurate. The type of ink is different, and ...

Embodiment 2

[0183] Example 2: 3D printed cartilage scaffold for osteochondral defect repair

[0184] For example Figure 8 , 9 As shown in 10 and 10, the target structure to be printed is firstly modeled, and then program control is implemented according to the established model to perform "color" volume imaging printing of different materials in different parts of the stent.

[0185] For example, the model built Figure 8 , 9 and 10, Figure 8 It is a cartilage scaffold model, which consists of two parts, namely Figure 9 the upper bracket and Figure 10 the lower bracket. Among them, the upper bracket has 30 round holes in the top view, and there are also 30 round holes on the side, and each round hole intersects.

[0186] Taking the above layer structure as an example, the cutting method of the model in this scheme is as follows Figure 11 shown. The image is cut along the center point 105, and the digital information is input into the image processing system. The cutting p...

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PUM

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Abstract

The invention provides an integrated colored optical 3D biological printing system based on an image-forming principle. The integrated colored optical 3D biological printing system based on the image-forming principle comprises an optical image-forming unit and an optical path conversion unit, through the optical image-forming unit, one or multiple optically-formed images of a to-be-printed main body are formed, through the optical path conversion unit, light paths of the formed images are projected into biological ink which can be cured by the light, so that through focusing of the light, thebiological ink is cured by the projected images, in this way, a more complex biological structure can be printed, and the precision is higher.

Description

technical field [0001] The present invention relates to an optical 3D bioprinting system and also to biomaterials for printing. Background technique [0002] Clinically, a large number of patients cannot live a normal life due to tissue and organ necrosis. At present, the main treatment methods still rely on autologous tissue transplantation or allogeneic organ donation. However, the amount of allogeneic tissue and organ donations is far from meeting the actual clinical needs. Not only that, the transplantation of allogeneic tissues or organs also has the risk of rejection, leading to transplant failure. Therefore, there are still a large number of patients who cannot receive treatment or cannot receive effective treatment. [0003] In recent years, with the development of tissue engineering and regenerative medicine, the construction of biologically active tissues and organs in vitro has become a major research hotspot. However, traditional tissue engineering methods ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/129B29C64/264B33Y30/00B33Y10/00
CPCB33Y10/00B33Y30/00B29C64/129B29C64/264
Inventor 欧阳宏伟梁仁杰洪逸章淑芳李琪恺邹毅玮周飞飞
Owner ZHEJIANG UNIV
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