Preparation method and application method of silicon dioxide nano microspheres

A technology of silica and nano-microspheres, which is applied in the direction of silica, silica, chemical instruments and methods, etc., can solve the problems of easy agglomeration of materials and small mesopore size, and achieve high specific surface area, large pore size, Effect of avoiding secondary nucleation and agglomeration problems

Inactive Publication Date: 2019-09-20
ZHOUKOU NORMAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation method and application method of silica nano-microspheres. The prepared silica nano-microspheres have a larger specific surface area, a larger radioactive mesoporous structure, and a higher resistance to biological macromolecules. Large sample loading capacity to overcome the problems of small mesopore size and easy agglomeration of materials in existing preparation methods

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  • Preparation method and application method of silicon dioxide nano microspheres
  • Preparation method and application method of silicon dioxide nano microspheres
  • Preparation method and application method of silicon dioxide nano microspheres

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Embodiment 1

[0030] A preparation method of silica nanospheres: Weigh 1.3 g TCMAC and 10.7 g CTAC respectively and disperse them into 120 mL of water, then mix 8 mL of tetraethyl orthosilicate and 32 mL of 1-octadecene and add to the reaction system, reacted at 150rpm for 10 minutes, added 0.4 g of triethylamine, and mechanically stirred at 60°C for 12 hours. After the reaction, the mixed solution was centrifuged at 10000 rpm for 20 minutes. Then the obtained precipitate was centrifuged and washed three times with ethanol, dried at 100 °C for 13 hours, then transferred to a muffle furnace after drying, and calcined at 600 °C for 13 hours. Monodisperse mesoporous nano silica microspheres can be obtained. The material was characterized by a pore size and specific surface area analyzer, the average pore size was 4.7 nm, and the specific surface area was 667.2 m 2 g -1 , with a porosity of 0.81 cm 3 g -1 . The average particle size of the material tested by a dynamic light scattering ins...

Embodiment 2

[0032]A preparation method of silica nanospheres: Weigh 2.8 g TCMAC and 9.2 g CTAC respectively and disperse them into 120 mL water, then mix 8 mL tetraethyl orthosilicate and 32 mL 1-octadecene and add to the reaction system, reacted at 150rpm for 10 minutes, added 0.4 g of triethylamine, and mechanically stirred at 60°C for 12 hours. After the reaction, the mixed solution was centrifuged at 10000 rpm for 20 minutes. Then the obtained precipitate was centrifuged and washed three times with ethanol, dried at 100 °C for 13 hours, then transferred to a muffle furnace after drying, and calcined at 600 °C for 13 hours. Monodisperse mesoporous nano silica microspheres can be obtained. The material was characterized by a pore size and specific surface area analyzer. The average pore size was 7.5 nm and the specific surface area was 658.5 m 2 g -1 , with a porosity of 0.27 cm 3 g -1 . The average particle size of the material tested by a dynamic light scattering instrument was ...

Embodiment 3

[0034] A preparation method of silica nanospheres: Weigh 4.5 g TCMAC and 7.5 g CTAC respectively and disperse them into 120 mL water, then mix 8 mL tetraethyl orthosilicate and 32 mL 1-octadecene and add to the reaction system, reacted at 150rpm for 10 minutes, added 0.4 g of triethylamine, and mechanically stirred at 60°C for 12 hours. After the reaction, the mixed solution was centrifuged at 10000 rpm for 20 minutes. Then the obtained precipitate was centrifuged and washed three times with ethanol, dried at 100 °C for 13 hours, then transferred to a muffle furnace after drying, and calcined at 600 °C for 13 hours. Monodisperse mesoporous nano silica microspheres can be obtained. The material was characterized by a pore size and specific surface area analyzer, the average pore size was 18.4 nm, and the specific surface area was 589.5 m 2 g -1 , with a porosity of 1.27 cm 3 g -1 . The average particle size of the material tested by a dynamic light scattering instrument w...

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Abstract

The purpose of the invention is to provide a preparation method and an application method of silicon dioxide nano microspheres. The preparation method of the silicon dioxide nano microspheres uses tetraethyl orthosilicate as a silicon source, double-template octadecyl trimethylammonium chloride and methyl trioctyl ammonium chloride as a pore making agent, triethylamine as a catalyst and a hydrophobic organic solvent and water as a two-phase system to prepare monodisperse silicon dioxide nano microspheres through a sol-gel process, and then removes the template by high-temperature calcination to prepare the monodisperse silicon dioxide nano microspheres. The prepared silicon dioxide nano microspheres has a large specific surface area, a large radioactive mesoporous structure and high sample loading amount for biomacromolecules so as to solve the problems of small mesoporous size and easy agglomeration of materials in a conventional preparation method.

Description

technical field [0001] The invention relates to a preparation method and application method of silicon dioxide nanometer microspheres. Background technique [0002] Due to its large specific surface area and adsorption capacity, mesoporous silica materials are widely used in the fields of adsorption, separation, and catalysis. Especially in the application of nano-drug delivery systems, mesoporous silica nanoparticles have become an excellent substitute for traditional organic emulsions or liposomes. However, the use of mesoporous silica for drug delivery is usually limited to molecular drugs because of the small pore size (<5 nm) of the as-prepared mesoporous silica nanoparticles. However, with the development of biomedicine, some macromolecular drugs (such as proteins and peptides, etc.) are increasingly used in the treatment of various human diseases. Therefore, the preparation of mesoporous silica nanospheres with larger specific surface area and larger pore size ha...

Claims

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Application Information

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IPC IPC(8): C01B33/18B01J20/10B01J20/28B01J20/30B82Y30/00B82Y40/00
CPCB01J20/103B01J20/28019B82Y30/00B82Y40/00C01B33/186C01P2004/03C01P2004/04C01P2004/32C01P2004/62C01P2004/64C01P2006/17
Inventor 夏红军田丰收王琳
Owner ZHOUKOU NORMAL UNIV
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