A kind of L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide and its preparation method

A technology of L-polylactic acid and composite material, which is applied in the field of L-polylactic acid composite material and its preparation, can solve the problems of enhancing the piezoelectric performance of the scaffold, insufficient mechanical strength, low cell activity, etc., so as to improve the hydrophilic ability and enhance the mechanical properties. , enhance the effect of interface polarization

Active Publication Date: 2022-03-11
JIANGXI UNIV OF SCI & TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the problems of insufficient mechanical strength, low cell activity and poor hydrophilicity in PLLA used as a bone graft material in the prior art, the purpose of the present invention is to provide a L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide and its preparation method, the larger surface area of ​​GO in the composite material can be nano BaTiO 3 The uniform deposition on its surface provides active sites and supports, while the nano-BaTiO intercalated between the GO layers 3 It can play a supporting role, thereby promoting the BaTiO 3 The uniform dispersion of GO and GO in the PLLA matrix enhances the mechanical properties of PLLA; on the other hand, GO has excellent electrical conductivity, and as conductive particles, it can effectively increase the dielectric constant of the scaffold, thereby promoting the BaTiO 3 The deflection of the dipole in the middle enhances the piezoelectric properties of the scaffold and promotes the proliferation and differentiation of osteoblasts under the action of electrical stimulation, so that the composite scaffold has good biological activity.

Method used

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  • A kind of L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide and its preparation method
  • A kind of L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide and its preparation method
  • A kind of L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Use an electronic balance to weigh 0.2g of GO powder with a particle size of 5-15 μm, add it to a beaker containing 30mL of absolute ethanol solution, and obtain a uniform and stable GO suspension under the action of mechanical stirring and ultrasound .

[0035] (2) Use an electronic balance to weigh 10g of BaTiO 3 Powder, the particle size is 0.1 ~ 1μm, added to a beaker filled with 50mL of absolute ethanol solution, under the action of mechanical stirring and ultrasonic, uniform and stable BaTiO 3 suspension.

[0036] (3) Use an electronic balance to weigh 89.8g of PLLA powder with a particle size of 60 μm and a melting point of 180°C, add it to a beaker containing 250mL of absolute ethanol solution, and obtain a uniform and stable powder under the action of mechanical stirring and ultrasound. PLLA suspension; then slowly add PLLA suspension to BaTiO 3and GO in the mixed suspension, and then the mixed solution was uniformly mixed by mechanical stirring and ultr...

Embodiment 2

[0042] (1) Use an electronic balance to weigh 0.1g of GO powder with a particle size of 5-15 μm, add it to a beaker containing 30mL of absolute ethanol solution, and obtain a uniform and stable GO suspension under the action of mechanical stirring and ultrasound .

[0043] (2) Use an electronic balance to weigh 10g of BaTiO 3 Powder, the particle size is 0.1 ~ 1μm, added to a beaker filled with 50mL of absolute ethanol solution, under the action of mechanical stirring and ultrasonic, uniform and stable BaTiO 3 suspension.

[0044] (3) Use an electronic balance to weigh 89.9g of PLLA powder with a particle size of 60 μm and a melting point of 180°C, add it to a beaker containing 250mL of absolute ethanol solution, and obtain a uniform and stable powder under the action of mechanical stirring and ultrasound. PLLA suspension; then slowly add PLLA suspension to BaTiO 3 Mix the suspension with GO, and then mix the mixed solution uniformly through magnetic stirring and ultrasonic...

Embodiment 3

[0050] (1) Use an electronic balance to weigh 0.3g of GO powder with a particle size of 5-15 μm, add it to a beaker containing 30mL of absolute ethanol solution, and obtain a uniform and stable GO suspension under the action of mechanical stirring and ultrasound .

[0051] (2) Use an electronic balance to weigh 10g of BaTiO 3 Powder, the particle size is 0.1 ~ 1μm, added to a beaker filled with 50mL of absolute ethanol solution, under the action of mechanical stirring and ultrasonic, uniform and stable BaTiO 3 suspension.

[0052] (3) Use an electronic balance to weigh 89.7g of PLLA powder with a particle size of 60 μm and a melting point of 180°C, add it to a beaker filled with 250mL of absolute ethanol solution, and obtain a uniform and stable powder under the action of mechanical stirring and ultrasound. PLLA suspension; then slowly add PLLA suspension to BaTiO 3 Mix the suspension with GO, and then mix the mixed solution uniformly through magnetic stirring and ultrasoni...

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Abstract

The invention discloses a L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide, wherein the mass fraction of PLLA is 80-90wt%, BaTiO 3 The mass fraction of GO is 9.5-19.9wt%, and the mass fraction of GO is 0.1-0.5wt%. GO in composites can be nano-BaTiO 3 Adhesive deposition on its surface provides active sites and supports, while nano-BaTiO intercalated between GO layers 3 It can play a supporting role, thereby promoting the BaTiO 3 The uniform dispersion of GO and GO in the PLLA matrix enhances the mechanical properties of PLLA; on the other hand, GO has excellent electrical conductivity, and as conductive particles, it can effectively increase the dielectric constant of the scaffold, thereby promoting the BaTiO 3 The deflection of the middle dipole can enhance the piezoelectric properties of the scaffold and promote the proliferation and differentiation of osteoblasts under the action of electrical stimulation, so that the composite scaffold has good biological activity.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide and a preparation method thereof. Background technique [0002] Artificial bone has attracted extensive attention from researchers at home and abroad because it can effectively alleviate the problems of limited bone mass in autologous or allogeneic bone, prone to immune reactions when implanted in the body, and difficulty in personalized manufacturing. Because polymer materials have good biological properties, they are widely used in artificial implant materials, among which poly(L-lactic acid), PLLA has good biocompatibility and biodegradability, and has been approved by the US Food and Drug Administration. FDA-approved material for implants. However, the use of PLLA as a bone graft material has problems such as insufficient mechanical strength, low cell acti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/18A61L27/02
CPCA61L27/50A61L27/18A61L27/025A61L2430/02C08L67/04
Inventor 杨友文帅词俊戚方伟彭淑平杨文静
Owner JIANGXI UNIV OF SCI & TECH
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