Composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins

A technology of heparin sodium enzyme and vitamins, which is applied in the field of composite aqueous solutions containing heparin sodium enzymolysis waste liquid and vitamins, can solve the problem of not preparing a composite aqueous solution containing heparin sodium enzymolysis waste liquid, etc., to ensure rapid growth and low cost , the effect of avoiding environmental pollution

Inactive Publication Date: 2019-10-01
广东百试特生物技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Combining fat-soluble vitamins and water-soluble vitamins with heparin sodium enzymolysis waste liquid is expected to produce a synergistic livestock and poultry health care nutrient solution, but there is no compound containing heparin sodium enzymolysis waste liquid. Related Technical Reports on Aqueous Solutions

Method used

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  • Composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins
  • Composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This example provides a composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins, which is prepared by the following method:

[0030] S1: Weigh the following fat-soluble vitamins: vitamin A oil (1 million IU / g) 5g, vitamin D 3 Oil (1 million IU / g) 2g, vitamin E oil 3g, vitamin K 3 0.5g, then the above-mentioned fat-soluble vitamins, lecithin 10g, and ethanol 5g were stirred and mixed evenly to obtain an oil phase;

[0031] S2: Weigh the following water-soluble vitamins: vitamin B 1 2g, vitamin B 2 1g, vitamin B 6 1g, vitamin B 12 3mg, 3g of vitamin C, 5g of nicotinamide, and then add the above-mentioned water-soluble vitamins, 5g of calcium pantothenate, 5g of inositol, and 1g of sodium benzoate into 300mL of heparin sodium enzymolysis waste liquid and stir to dissolve, so as to obtain an aqueous phase;

[0032] S3: add the water phase to the oil phase, and grind and mix evenly through a colloid mill to obtain a mixed solution...

Embodiment 2

[0035] This example provides a composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins, which is prepared by the following method:

[0036] S1: Weigh the following fat-soluble vitamins: vitamin A oil (1 million IU / g) 20g, vitamin D 3 Oil (1 million IU / g) 5g, vitamin E oil 10g, vitamin K 3 1g, then the above-mentioned fat-soluble vitamins, Tween80 10g, Span8010g, 1,2-propanediol 5g, glycerin 5g, stirred and mixed evenly to obtain an oil phase;

[0037] S2: Weigh the following water-soluble vitamins: vitamin B 1 3g, vitamin B 2 3g, vitamin B 6 3g, vitamin B 12 10mg, vitamin C10g, nicotinamide 10g, and then the above water-soluble vitamins, calcium pantothenate 10g, inositol 5g, sodium benzoate 1g, potassium sorbate 1g, add 400mL heparin sodium enzymolysis waste liquid and stir to dissolve to prepare the aqueous phase;

[0038] S3: add the water phase to the oil phase, and grind and mix evenly through a colloid mill to obtain a mixed s...

Embodiment 3

[0041] This example provides a composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins, which is prepared by the following method:

[0042] S1: Weigh the following fat-soluble vitamins: vitamin A oil (1 million IU / g) 30g, vitamin D 3 Oil (1 million IU / g) 10g, vitamin E oil 20g, vitamin K 3 5g, then the above-mentioned fat-soluble vitamins, lecithin 20g, soybean lecithin 20g, ethanol 5g, glycerol 15g, stir and mix, and make the oil phase;

[0043] S2: Weigh the following water-soluble vitamins: vitamin B 1 5g, vitamin B 2 5g, vitamin B 6 5g, vitamin B 1220mg, 20g of vitamin C, 20g of nicotinamide, and then add 500mL of heparin sodium enzymolysis waste liquid and stir to dissolve the above-mentioned water-soluble vitamins, 20g of calcium pantothenate, 2g of sodium benzoate, and 2g of potassium sorbate, and stir to obtain an aqueous phase;

[0044] S3: add the water phase to the oil phase, and grind and mix evenly through a colloid mill...

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Abstract

The invention relates to a composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins. The composite aqueous solution is prepared by using the method comprising the steps that the lipid-soluble vitamins, an emulsifier and an alcohol co-emulsifier are evenly mixed to prepare an oil phase; water-soluble vitamins are added to heparin sodium enzymolysis waste liquid with the volume being 30-50% of the total volume of the composite aqueous solution and dissolved to prepare a water phase; the water phase is added into the oil phase, and grinding and uniform mixing areconducted to obtain a mixed solution; heparin sodium enzymolysis waste liquid is added into the mixed solution for uniform mixing to obtain the composite aqueous solution, so that each liter of the composite aqueous solution contains 10-65 g of the lipid-soluble vitamins, 15-75 g of the water-soluble vitamins, 10-40 g of the emulsifier and 5-20 g of the alcohol co-emulsifier. The aqueous solutiongives full play to the synergistic interaction of the heparin sodium enzymolysis waste liquid and the vitamins, the composite aqueous solution can be applied through drinking, and used in the aspectsof feed for livestock and poultry, veterinary drugs and the like, quick growth of the livestock and poultry is ensured, and the morbidity of the livestock and poultry is reduced.

Description

technical field [0001] The application belongs to the technical field of livestock and poultry feed and veterinary medicine, and in particular relates to a composite aqueous solution containing heparin sodium enzymolysis waste liquid and vitamins. Background technique [0002] Heparin sodium is a mucopolysaccharide sulfate anticoagulant substance, which produces anticoagulant function by combining with antithrombin. It is the most effective and clinically used anticoagulant drug in the world. At present, heparin sodium cannot be synthesized artificially and is mainly extracted from animal tissues, with the highest content in the pig small intestinal mucosa. my country is a big pig breeding, slaughtering and consuming country, and has rich pig small intestine resources. There are a large number of domestic manufacturers dedicated to extracting heparin sodium from the small intestine mucosa. [0003] At present, the more commonly used extraction method of heparin sodium is th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/105A23K20/158A23K20/174A23K20/24A23K30/00A61K35/38A61K9/08A61P3/02A61K31/07A61K31/593A61K31/355A61K31/122A61K31/51A61K31/525A61K31/4415A61K31/714A61K31/375A61K31/455A61K31/197A61K31/047
CPCA23K20/174A23K20/24A23K20/105A23K20/158A23K30/00A61K35/38A61K31/07A61K31/593A61K31/355A61K31/122A61K31/51A61K31/525A61K31/4415A61K31/714A61K31/375A61K31/455A61K31/197A61K31/047A61K9/08A61P3/02A61K2300/00
Inventor 魏海涛方秋华李家伟李涛赵云余细红向亚林刘初亮
Owner 广东百试特生物技术研究院有限公司
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