Telmisartan flavor chewable tablet and preparing method thereof

A technology for telmisartan and chewable tablets, applied in the field of telmisartan flavored chewable tablets and preparation thereof, can solve the problems of unsolvable and low bioavailability, and achieves improved stability, simple process, isolation and neutralization reaction Effect

Inactive Publication Date: 2019-10-11
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method can only cover the bitter taste of the active ingredient in the process of oral chewing, and cannot solve the problem that the neutralization reaction be

Method used

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  • Telmisartan flavor chewable tablet and preparing method thereof
  • Telmisartan flavor chewable tablet and preparing method thereof
  • Telmisartan flavor chewable tablet and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0040] Preparation of coating solution

[0041]Prepare 100ml of 20% ethanol-water solution, add 6g of carboxymethyl ethyl cellulose, 2g of lauric acid, 2g of sodium citrate, 1g of ascorbic acid, and 2g of cyclodextrin, and stir evenly to obtain coating solution A.

[0042] Prepare 100ml of 20% ethanol-water solution, add 6g of hydroxypropyl methylcellulose, 2g of lauric acid, 2g of sodium citrate, 1g of ascorbic acid, and 2g of cyclodextrin, and stir evenly to obtain coating solution B.

preparation example 2

[0044] This embodiment prepares the telmisartan flavor chewable tablet of the present invention, is made by the raw material of percentage by weight as in Table 1:

[0045] Table 1 Components and contents of telmisartan flavor chewable tablets of the present invention

[0046]

[0047] Preparation method: pass telmisartan, sodium hydroxide, meglumine, starch glycoside, chitosan, cornstarch, cross-linked polyvinylpyrrolidone and artificial beef essence through 80-mesh sieve respectively, and take the sieved product in proportion Mix telmisartan, sodium hydroxide, meglumine, starch glucoside, chitosan, and cross-linked polyvinylpyrrolidone evenly, use 5% polyvinylpyrrolidone aqueous solution to make a soft material, and pass through a 40-mesh sieve granules, dried at 40°C, passed through 40 mesh and 65 mesh sieves for granulation, and removed coarse particles and fine powders to obtain granules; the above granules were fluidized bed coated with the coating solution A prepared...

preparation example 3

[0049] This embodiment prepares the telmisartan flavor chewable tablet of the present invention, is made of the raw material such as table 2 weight percent:

[0050] Table 2 Components and contents of telmisartan flavor chewable tablets of the present invention

[0051]

[0052]

[0053] Preparation method: pass telmisartan, sodium hydroxide, meglumine, starch glycoside, chitosan, cornstarch, cross-linked polyvinylpyrrolidone and artificial beef essence through 80-mesh sieve respectively, and take the sieved product in proportion Mix telmisartan, sodium hydroxide, meglumine, starch glucoside, chitosan, and cross-linked polyvinylpyrrolidone evenly, use 5% polyvinylpyrrolidone aqueous solution to make a soft material, and pass through a 40-mesh sieve granules, dried at 40°C, passed through 40 mesh and 65 mesh sieves for granulation, and removed coarse particles and fine powders to obtain granules; the above granules were fluidized bed coated with the coating solution A pre...

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PUM

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Abstract

The invention relates to a telmisartan flavor chewable tablet. The telmisartan flavor chewable tablet is prepared from, by weight, 10-30% of telmisartan, 20-35% of a diluent, 30-45% of a filler, 1-10%of an alkalizer, 1-10% of a disintegrating agent, 1-5% of an adhesive, 5-20% of a flavoring agent and 2-5% of a coating agent. By means of a coating material, granules with the telmisartan and alkalizer are coated through a fluidized bed, the solubility and bioavailability of the telmisartan in the intestinal environment are improved, and the bitter taste and oral mucosa irritation caused when adog chews the telmisartan tablet are effectively removed. The beef flavor telmisartan chewable tablet is high in palatability, and the medicine compliance of a pet is improved.

Description

technical field [0001] The invention belongs to the field of veterinary pharmaceutical preparations, in particular to a telmisartan flavored chewable tablet and a preparation method thereof. Background technique [0002] Domestic companion pets have good living conditions and lack of sufficient exercise, and often suffer from overnutrition and obesity. The resulting cardiovascular diseases such as hypertension, heart disease and kidney disease have become common clinical diseases in elderly pets. Congestive heart failure and chronic kidney disease in pet dogs and cats are both progressive and irreversible chronic diseases. Once the disease occurs, it means permanent pathological damage to the heart and kidneys. After the elderly pet dogs and cats get sick, if they are not treated in time, various complications will occur, resulting in a serious decline in the quality of life and a greatly shortened life span, which will cause great economic and emotional pressure on pet owne...

Claims

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Application Information

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IPC IPC(8): A61K9/26A61K9/62A61K47/38A61K47/02A61K47/18A61K31/4184A61P9/12
CPCA61K9/0056A61K9/2009A61K9/2013A61K9/2054A61K9/2081A61K9/5042A61K31/4184
Inventor 张许科晏磊
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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