Antitumor platinum drug mineralization protein nanoparticles and preparation method and application thereof

A platinum drug and nanoparticle technology, which is applied in the field of biomedicine to achieve good tumor cytotoxicity and reverse tumor drug resistance.
CN110368374AActive Publication Date: 2019-10-25SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2019-10-25

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Abstract

The invention discloses antitumor platinum drug mineralization protein nanoparticles and a preparation method and application thereof. The antitumor platinum drug mineralization protein nanoparticlesand the preparation method thereof have the advantages that the platinum drug mineralization protein nanoparticles are successfully prepared through the two-step preparation method for the first time,the prepared nanoparticles can be uniformly dispersed in an aqueous solution, the nanoparticles has good cytotoxicity, and the IC50 of the nanoparticles to human non-small-cell lung cancer cells A549is 6.9 microgram / ml; the platinum drug mineralization protein nanoparticles comprising a platinum drug and protein are simple in preparation process, uniform in size, controllable in particle size, good in biocompatibility, good in water solubility, long in blood circulation time, high in tumor targeting performance and capable of laying a foundation for efficient tumor treatment or drug-resistant tumor treatment.
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Description

technical field

[0001] The invention belongs to biomedicine technology, and in particular relates to a platinum drug mineralization protein nanoparticle and its preparation method and application. Background technique

[0002] Platinum drugs are commonly used clinical anti-tumor chemotherapy drugs, which have broad-spectrum anti-tumor effects. Platinum drugs also have many deficiencies, such as poor curative effect, high toxicity and side effects, poor targeting, and prone to tumor drug resistance. Nano-drug carriers (such as polymer micelles, vesicles, etc.) can improve this. However, platinum-based antineoplastic drugs commonly used in clinical practice (such as cisplatin and its derivatives) are difficult to pass through due to their poor water and oil solubility. Traditional nanocarrier entrapment usually uses chemical coupling or prodrug modification to achieve its loading in the carrier, but these nano-drug carriers often have disadvantages such as difficult to effect...

Claims

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