A kind of biopolymer superfine fiber prepared based on centrifugal spinning and its preparation method

Abstract

The invention discloses a biopolymer ultrafine fiber prepared based on centrifugal spinning. The ultrafine fiber is prepared by a centrifugal spinning method. The spinning precursor solution for preparing the ultrafine fiber is composed of a biopolymer, a spinning aid and solvent, the fiber diameter of the prepared ultrafine fibers is 0.5-20 μm. The invention combines the natural biopolymer and the synthetic biopolymer to prepare the composite ultrafine fiber material based on the centrifugal spinning method, which can not only improve the hydrophilic properties of the spinning assistant, but also improve the mechanical properties of the biopolymer fiber. The superfine fiber prepared by the invention can be applied to wounds caused by various emergencies, and covering the wound surface can prevent the loss of water in body fluids, keep the wound surface free of fluid accumulation, and prevent bacterial infection, thereby reducing inflammation, hemostasis, Analgesia and promote wound healing.

Description

technical field

[0001] The invention relates to the technical field of biomedical materials, in particular to a biopolymer ultrafine fiber prepared based on centrifugal spinning and a preparation method thereof. Background technique

[0002] With the rapid development of modern industry, transportation, and construction, traumas caused by various accidents are increasing day by day, among which acute trauma and burns are the most common. Acute trauma mainly has problems such as high infection rate, slow wound healing, complex injury and easy to be affected by the environment. Improper treatment of wound will directly endanger the prognosis of the wounded, and even endanger life. Covering the wound surface with medical dressings not only helps to promote wound healing, but also effectively prevents wound infection. However, traditional medical dressings such as gauze, bandages, absorbent cotton, etc. can only play the role of wound protection barriers, do not have the effect...

Examples

Embodiment 1

[0042] A kind of biopolymer superfine fiber prepared based on centrifugal spinning, said superfine fiber is made by centrifugal spinning method, and the spinning precursor solution of preparing this superfine fiber is made of chitosan (CS), polyoxyethylene (PEO) Composed of water and water, the fiber diameter of the superfine fiber is 2-5 μm.

[0043] A method for preparing biopolymer ultrafine fibers based on centrifugal spinning, comprising the steps of:

[0044] S1, prepare spinning precursor solution: dissolve 1g chitosan (CS) and 5g polyoxyethylene (PEO) in 44g water, stir until forming homogeneous spinning precursor solution;

[0045] S2. Centrifugal spinning: inject the above-mentioned spinning precursor solution into a plane-receiving centrifugal spinning device and perform centrifugal spinning at 70°C. The spinneret aperture is 0.16mm, the spinning collection distance is 10cm, and the spinning speed is 8000r / min. , to obtain ultrafine fibers, and then vacuum-dried at...

Embodiment 2-4

[0047] Embodiment 2-4 provides a kind of biopolymer microfiber prepared based on centrifugal spinning, compared with embodiment 1, the difference is that in the ultrafine fiber preparation method step S1 of changing, chitosan (CS) and poly The mass ratio of ethylene oxide (PEO), except for the above differences, other operations are the same, so it will not be repeated here; the specific condition parameters are shown in the table below.

[0048]

[0049]

[0050] Adopt scanning electron microscope to carry out characterizing to the superfine fiber that embodiment 1~4 makes, the result is as follows respectively Figure 4 As shown in (a), (b), (c) and (d), the results in the figure show that with the increase of chitosan mass percentage, the fiber diameter and uniformity first decrease and then increase. When the mass percent of polysaccharide is 6% ( Figure 4 In (c)), the fiber continuity uniformity is the best, the diameter distribution is concentrated, the average f...

Embodiment 5-14

[0052] Embodiments 5-14 provide a kind of biopolymer microfiber prepared based on centrifugal spinning. Compared with Example 3, the difference is that in step S2 of the superfine fiber preparation method, the collection distance of centrifugal spinning, spinning Except for the above differences, other operations are the same for filament temperature, spinneret aperture, and spinning speed, and will not be repeated here; the specific condition parameters are shown in the table below.

[0053]

[0054]

technical field

[0001] The invention relates to the technical field of biomedical materials, in particular to a biopolymer ultrafine fiber prepared based on centrifugal spinning and a preparation method thereof. Background technique

[0002] With the rapid development of modern industry, transportation, and construction, traumas caused by various accidents are increasing day by day, among which acute trauma and burns are the most common. Acute trauma mainly has problems such as high infection rate, slow wound healing, complex injury and easy to be affected by the environment. Improper treatment of wound will directly endanger the prognosis of the wounded, and even endanger life. Covering the wound surface with medical dressings not only helps to promote wound healing, but also effectively prevents wound infection. However, traditional medical dressings such as gauze, bandages, absorbent cotton, etc. can only play the role of wound protection barriers, do not have the effect...

Examples

Embodiment 1

[0042] A kind of biopolymer superfine fiber prepared based on centrifugal spinning, said superfine fiber is made by centrifugal spinning method, and the spinning precursor solution of preparing this superfine fiber is made of chitosan (CS), polyoxyethylene (PEO) Composed of water and water, the fiber diameter of the superfine fiber is 2-5 μm.

[0043] A method for preparing biopolymer ultrafine fibers based on centrifugal spinning, comprising the steps of:

[0044] S1, prepare spinning precursor solution: dissolve 1g chitosan (CS) and 5g polyoxyethylene (PEO) in 44g water, stir until forming homogeneous spinning precursor solution;

[0045] S2. Centrifugal spinning: inject the above-mentioned spinning precursor solution into a plane-receiving centrifugal spinning device and perform centrifugal spinning at 70°C. The spinneret aperture is 0.16mm, the spinning collection distance is 10cm, and the spinning speed is 8000r / min. , to obtain ultrafine fibers, and then vacuum-dried at...

Embodiment 2-4

[0047] Embodiment 2-4 provides a kind of biopolymer microfiber prepared based on centrifugal spinning, compared with embodiment 1, the difference is that in the ultrafine fiber preparation method step S1 of changing, chitosan (CS) and poly The mass ratio of ethylene oxide (PEO), except for the above differences, other operations are the same, so it will not be repeated here; the specific condition parameters are shown in the table below.

[0048]

[0049]

[0050] Adopt scanning electron microscope to carry out characterizing to the superfine fiber that embodiment 1~4 makes, the result is as follows respectively Figure 4 As shown in (a), (b), (c) and (d), the results in the figure show that with the increase of chitosan mass percentage, the fiber diameter and uniformity first decrease and then increase. When the mass percent of polysaccharide is 6% ( Figure 4 In (c)), the fiber continuity uniformity is the best, the diameter distribution is concentrated, the average f...

Embodiment 5-14

[0052] Embodiments 5-14 provide a kind of biopolymer microfiber prepared based on centrifugal spinning. Compared with Example 3, the difference is that in step S2 of the superfine fiber preparation method, the collection distance of centrifugal spinning, spinning Except for the above differences, other operations are the same for filament temperature, spinneret aperture, and spinning speed, and will not be repeated here; the specific condition parameters are shown in the table below.

[0053]

[0054]

Images