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A preparation method of a surface-enhanced Raman scattering chip that can be used for trace detection, and the resulting product and application

A surface-enhanced Raman and trace technology, applied in Raman scattering, measuring devices, instruments, etc., can solve the problems of difficult storage of products and complicated preparation process, and achieve excellent performance of surface-enhanced Raman, simple preparation of raw materials, and easy use convenient effect

Active Publication Date: 2022-02-15
HAINAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above reported strategies have many disadvantages in practical application, such as complex preparation process, difficult storage of products, need to use special reagents or more complex instruments and equipment, etc.

Method used

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  • A preparation method of a surface-enhanced Raman scattering chip that can be used for trace detection, and the resulting product and application
  • A preparation method of a surface-enhanced Raman scattering chip that can be used for trace detection, and the resulting product and application
  • A preparation method of a surface-enhanced Raman scattering chip that can be used for trace detection, and the resulting product and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]Accurately weigh 800 mg of melamine and dissolve it in 250 mL of ultrapure water, and heat to keep the solution at a constant temperature of 60±5 °C. Under stirring conditions, slowly pour 50 mL of silver nitrate aqueous solution with a concentration of 38 mM into the above-mentioned hot melamine aqueous solution, and continue stirring to obtain a colorless and transparent colloidal solution.

[0042] Take a substrate with a groove capacity of 10 μl, and quickly transfer 10 μl of the above colloid solution to each groove of the array substrate with a pipette. All the solvents in the grooves are volatilized, and the white xerogel film evenly covers the bottom of each groove. Transfer the above-mentioned substrate containing the xerogel film to a muffle furnace, slowly raise the temperature to 450°C at a rate of 2°C / min in an air atmosphere, and keep the temperature at this temperature for 180min to remove the organic components and make the precious metal The ions are re...

Embodiment 2

[0044] Accurately weigh 400 mg of carbonamide and dissolve it in 250 mL of ultrapure water, and slowly pour 50 mL of silver nitrate aqueous solution with a concentration of 38 mM into the above carbonamide aqueous solution under stirring at room temperature, and continue stirring to obtain a colorless and transparent colloidal solution.

[0045] Take a substrate with a groove capacity of 50 μl, and quickly transfer 50 μl of the above colloid solution to each groove of the array substrate with a pipette. All the solvents in the grooves are volatilized, and the white xerogel film evenly covers the bottom of each groove. Transfer the above-mentioned substrate containing the xerogel film to a muffle furnace, slowly raise the temperature to 400°C at a rate of 5°C / min under a nitrogen atmosphere, and keep the temperature at this temperature for 120min to remove the organic components and make the precious metal The ions are reduced to a noble metal film with a rough surface, and th...

Embodiment 3

[0047] Accurately weigh 550 mg of thiourea and dissolve it in 250 mL of ultrapure water, and slowly pour 100 mL of 20 mM sodium chloroaurate aqueous solution into the above-mentioned thiourea aqueous solution under stirring at room temperature, and continue stirring to obtain light Yellow transparent colloidal solution.

[0048] Take a substrate with a groove capacity of 100 μl, and quickly transfer 100 μl of the above colloid solution to each groove of the array substrate with a pipette. All the solvents in the grooves were volatilized, and the light yellow xerogel film evenly covered the bottom of each groove. Transfer the above-mentioned substrate containing the xerogel film to a muffle furnace, slowly raise the temperature to 500 °C at a rate of 10 °C / min in the air, and keep the temperature at this temperature for 60 min to remove the organic components and make the noble metal ions After reducing to a noble metal film with a rough surface, and then naturally cooling to ...

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Abstract

The invention discloses a method for preparing a surface-enhanced Raman scattering chip that can be used for trace detection, as well as the product and application thereof. The method forms a uniform transparent sol through a liquid-phase reaction of an amino-containing organic matter and a noble metal precursor, and then transfers it to In-situ aging reaction and heat treatment reaction are carried out in the substrate with arrayed grooves, and a chip for surface-enhanced Raman detection with a uniform noble metal film at the bottom of the grooves is obtained. The preparation material of the present invention is easy to obtain, the process is simple, the surface of the obtained chip has excellent Raman performance, the advantages of large-scale production and application are obvious, and it is suitable for the simple, rapid and highly sensitive detection of micro-trace substance molecules.

Description

technical field [0001] The invention relates to a method for preparing a low-cost, large-scale prepared chip that can be used for trace detection and has excellent surface-enhanced Raman scattering performance, and the obtained chip and application, belonging to the technical field of micro-trace analysis and detection. Background technique [0002] Surface-enhanced Raman scattering (SERS) is the Raman scattering signal enhancement generated by the local surface plasmon resonance of noble metal plasma. This Raman scattering spectroscopy technology can significantly improve the detection signal intensity of the detection object and realize trace level detection. Even single-molecule level analysis, detection and research can be achieved; at the same time, the enhancement of the signal can further broaden the application range of Raman spectroscopy. Therefore, considering the actual application situation, the key to the application of SERS technology depends on the effective a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65C23C18/42C23C18/16
CPCG01N21/658C23C18/42C23C18/1682C23C18/1678
Inventor 窦智峰赵鑫赵振东张名楠
Owner HAINAN UNIV
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