Electrochemical preparation method of alkynyl thiocyanate

An alkynyl thiocyanate, electrochemical technology, applied in the electrolysis process, electrolysis components, electrolysis organic production and other directions, can solve the problems of complex reaction raw materials, and achieve the effects of simple and easy-to-obtain raw materials, low commercial price, and stable properties
CN110453241AActive Publication Date: 2019-11-15SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2019-11-15

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Abstract

Belonging to the technical field of electrochemical organic synthesis, the invention discloses an electrochemical preparation method of alkynyl thiocyanate. The preparation method includes the steps of: adding a solvent (acetonitrile and water), electrolyte, alkali, a thiocyanate, phenylpropiolic acid, and negative and positive electrodes into a diaphragm-free electrolytic tank, performing stirring, and carrying out reaction under a constant current condition; and at the end of the reaction, conducting separation and purification to obtain the product alkynyl thiocyanate. The electrodes used by the method are general inert electrode, have no need for electrode modification and extra adding of various metal catalysts, thereby avoiding the use of toxic, expensive and complicatedly prepared catalyst, the reaction yield is high, the reaction system is simple, and the operation is carried out under normal temperature and pressure, the method is simple and safe, and is suitable for large-scale industrial production.
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Description

technical field

[0001] The invention belongs to the technical field of electrochemical organic synthesis, and in particular relates to an electrochemical preparation method of alkynyl thiocyanate. Background technique

[0002] Organic sulfur-containing compounds widely exist in our daily life. They not only exist in our body as cysteine ​​and methionine, but also are the main components of penicillin, nelfinavir and quetiapine and other drugs. As an important part of organic sulfides, alkynyl thiocyanate compounds can not only be oxidized into α-thiocyanoketone, but also use it as a functional molecule to generate four thiocyanate compounds under the action of azide, aniline, and sodium borohydride, respectively. oxazole, aminothiazole and thiazolidine and other key drug intermediates, and can also be decyanated and trifluoromethylated to synthesize alkynyl trifluoromethyl sulfide and alkynyl sulfide compounds under the action of trifluoro reagent and Grignard reagent. Expa...

Claims

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