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Method used for preparing antibacterial polymer film through chemical vapor deposition, and applications

A chemical vapor deposition, polymer film technology, applied in the field of materials, can solve the problems of adhesion of bacterial debris and poor biocompatibility, and achieve the effect of reducing bacterial infection and high application value

Active Publication Date: 2019-11-19
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the shortcomings of poor biocompatibility of positively charged bactericidal polymers and adhesion to bacterial remains, the invention provides a method and application of chemical vapor deposition for preparing antibacterial polymer films. The preparation method is a simple, High efficiency, mild reaction conditions, one-step synthesis of double-layer polymer film P(DMAMS-co-EGDA) with sterilization, pH-responsive release of bacterial debris, recyclable and good biocompatibility by polymer chemical vapor deposition method -g-P(VP-co-EGDA)(DMAMS: dimethylaminomethyl styrene, N,N-dimethylvinylbenzylamine; EGDA: ethyleneglycol diacrylate, ethylene glycol diacrylate; VP: N-vinyl-2-pyrrolidone, 1-vinyl-2-pyrrolidone)

Method used

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  • Method used for preparing antibacterial polymer film through chemical vapor deposition, and applications
  • Method used for preparing antibacterial polymer film through chemical vapor deposition, and applications
  • Method used for preparing antibacterial polymer film through chemical vapor deposition, and applications

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Preparation of bilayer P(DMAMS-co-EGDA)-g-P(VP-co-EGDA):

[0040] Plastic, glass, and silicon wafer materials are used as substrates and placed on the sample stage of a polymer chemical vapor deposition reactor. Initiator di-tert-butyl peroxide (TBP), functional monomer N,N-dimethylvinylbenzylamine (DMAMS), and cross-linking agent ethylene glycol diacrylate (EGDA) were heated to 30, 75 and 65°C, make it gasify and flow into the reactor, the flow of each monomer is controlled by a mass flow controller, and the molar ratio of DMAMS / EGDA monomer is 14:1. Nichrome wires were neatly arranged 2.5 cm above the reaction table and heated to 250 °C. Initiator TBP enters the reactor, is heated and decomposed by nickel-chromium wire to generate free radicals, and then initiates free radical chain polymerization, and the synthesized high polymer is deposited on the base material and the control silicon wafer. During the deposition process, the substrate temperature is controlled b...

Embodiment 2

[0057] A kind of chemical vapor deposition method of the present invention prepares the method for antibacterial polymer film, comprises the following steps:

[0058] The substrate is placed on the sample stage of the polymer chemical vapor deposition reactor with plastic sheet, glass sheet, and silicon sheet material as the substrate. Initiator di-tert-butyl peroxide (TBP), functional monomer N,N-dimethylvinylbenzylamine (DMAMS), and cross-linking agent ethylene glycol diacrylate (EGDA) were heated to 30, 75 and 65 ° C, make it gasify and flow into the reactor, and the flow rate of each monomer is controlled by a mass flow controller. Nichrome wires were neatly arranged 2.5 cm above the reaction table and heated to 200°C. Initiator TBP enters the reactor, is heated and decomposed by nickel-chromium wire to generate free radicals, and then initiates free radical chain polymerization, and the synthesized high polymer is deposited on the base material and the control silicon wa...

Embodiment 3

[0061] A kind of chemical vapor deposition method of the present invention prepares the method for antibacterial polymer film, comprises the following steps:

[0062] The substrate is placed on the sample stage of the polymer chemical vapor deposition reactor with plastic sheet, glass sheet, and silicon sheet material as the substrate. Initiator di-tert-butyl peroxide (TBP), functional monomer N,N-dimethylvinylbenzylamine (DMAMS), and cross-linking agent ethylene glycol diacrylate (EGDA) were heated to 30, 75 and 65 ° C, make it gasify and flow into the reactor, and the flow rate of each monomer is controlled by a mass flow controller. Nichrome wires were neatly arranged 2.8 cm above the reaction table and heated to 300°C. The initiator TBP enters the reactor, is heated and decomposed by the nickel-chromium wire to generate free radicals, and then initiates a free radical chain polymerization reaction, and the synthesized polymer is deposited on the base material and the cont...

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Abstract

The invention discloses a method used for preparing antibacterial polymer film through chemical vapor deposition, and applications, and belongs to the technical field of material. The method is used for solving problems in the prior art that negatively charged sterilizing polymer biological compatibility is poor, and adhesion of bacterium remains is caused. The method is simple, and high in efficiency. According to the method, high-molecular chemical vapor deposition is adopted under mild conditions, one-step synthesis of double-layer high-molecular antibacterial film P(DMAMS-co-EGDA)-g-P(VP-co-EGDA). The double-layer high-molecular antibacterial film possesses the sterilizing function of lower layer P(DMAMS-co-EGDA), and the excellent biological compatibility of upper layer P(VP-co-EGDA);and in addition, after sterilization, environment pH value is increased, so that shedding of bacterium remains on the double-layer film is easily caused, bacterium adhesion prevention is realized, recycling for a plurality of times can be realized, the excellent stability is beneficial for applications on medical instrument surfaces, and bacterium infection is reduced.

Description

technical field [0001] The invention belongs to the technical field of materials and relates to the preparation of an antibacterial polymer film, in particular to a method and application of a chemical vapor deposition method for preparing an antibacterial polymer film. Background technique [0002] In recent years, antibacterial polymers have been widely used in the field of biomedicine. By modifying the surface of biomedical materials, antibacterial polymers can effectively improve the antibacterial efficiency of biomedical materials and reduce the chance of bacterial infection of medical materials. Most bacteria are negatively charged in the natural environment. Therefore, the positively charged antibacterial polymer attracts bacteria through electrostatic interaction and migrates the substances in the bacterial cell wall and cell membrane, thereby destroying the structure of the bacterial cell wall and cell membrane, resulting in bacterial death. Such as polyquaternium a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/14C08F222/14C08F226/10B05D1/00B05D7/24B05D7/02B05D5/00A61L31/10A61L31/14
CPCA61L31/10A61L31/14A61L2400/18A61L2420/02B05D1/60B05D5/00B05D7/02B05D7/24B05D7/54B05D2201/02B05D2203/30B05D2203/35B05D2451/00C08F212/14C08F226/10
Inventor 宋青李鹏谢玫珍黄维
Owner NORTHWESTERN POLYTECHNICAL UNIV