Continuous ethanol recovery and salicylic acid removal process for carbaspirin calcium mother liquor

A technology of carbasalate calcium and salicylic acid, which is applied in the fields of organic chemistry, chemical instruments and methods, preparation of hydroxyl compounds, etc., can solve the problems not involving the recycling of carbasalate calcium mother liquor, and achieve good properties, low energy consumption, low cost effect

Inactive Publication Date: 2019-11-22
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it does not involve the recycling of carbasalate calcium mother liquor

Method used

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  • Continuous ethanol recovery and salicylic acid removal process for carbaspirin calcium mother liquor

Examples

Experimental program
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Effect test

Embodiment 1

[0033]Distillation tower (T01) and rectification tower (T02) feed flow rate is 785kg / h, and feed temperature is 30 ℃, and contains ethanol 72.5%, water 18.8%, salicylic acid 1.7%, ammonium nitrate 7% in the feed % (mass fraction), the operating pressure is 1atm (absolute pressure), the number of theoretical plates is 40, the raw material feed plate is 30, the reflux ratio is 4.5, and the output at the top of the tower is 579kg / h, and the rectifying tower (T03) enters The material flow rate is 1158kg / h, the feed temperature is 78°C, the operating pressure is 1atm (absolute pressure), the number of theoretical plates is 20, the raw material feeding plate is 3, the reflux ratio is 2.9, and the output at the top of the tower is 61.5kg / h, the rectifying tower (T04) feed flow rate is 412kg / h, and feed temperature is 93 ℃, and operating pressure is 1atm (absolute pressure), and theoretical plate number is 20, and raw material feed plate is 8, and reflux ratio is 1.5, The output at t...

Embodiment 2

[0035] The rectification tower (T01) and the rectification tower (T02) feed flow rate are 1100kg / h, and the feed temperature is 32 ℃, and the feed contains ethanol 72.5%, water 18.8%, salicylic acid 1.7%, ammonium nitrate 7% % (mass fraction), the operating pressure is 1atm (absolute pressure), the number of theoretical plates is 45, the raw material feed plate is 30, the reflux ratio is 4.3, and the output at the top of the tower is 811kg / h, and the rectifying tower (T03) enters The material flow rate is 1622kg / h, the feed temperature is 78°C, the operating pressure is 1atm (absolute pressure), the number of theoretical plates is 25, the raw material feeding plate is 3, the reflux ratio is 2.5, and the output at the top of the tower is 86kg / h , the rectification column (T04) feed flow rate is 578kg / h, the feed temperature is 93°C, the operating pressure is 1atm (absolute pressure), the number of theoretical plates is 20, the raw material feed plate is 8, and the reflux ratio i...

Embodiment 3

[0037] Distillation tower (T01) and rectification tower (T02) feed flow rate is 650kg / h, and feed temperature is 40 ℃, and contains ethanol 72.5%, water 18.8%, salicylic acid 1.7%, ammonium nitrate 7% in the feed % (mass fraction), the operating pressure is 1atm (absolute pressure), the number of theoretical plates is 50, the raw material feed plate is 30, the reflux ratio is 4, and the output at the top of the tower is 479kg / h, and the rectifying tower (T03) enters The material flow rate is 958kg / h, the feed temperature is 78°C, the operating pressure is 1atm (absolute pressure), the number of theoretical plates is 20, the raw material feeding plate is 4, the reflux ratio is 3.2, and the output at the top of the tower is 51kg / h , the rectification tower (T04) feed flow rate is 342kg / h, and feed temperature is 93 ℃, and operating pressure is 1atm (absolute pressure), and theoretical plate number is 25, and raw material feed plate is 18, and reflux ratio is 3, and column The to...

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Abstract

The invention provides a continuous ethanol recovery and salicylic acid removal process for carbaspirin calcium mother liquor and a device suitable for the method. According to the method, continuousethanol recovery and salicylic acid removal of the carbaspirin calcium mother liquor are realized, and a feasible process route suitable for a continuous ethanol recovery and salicylic acid removal technology of the carbaspirin calcium mother liquor is developed. According to the process, it is guaranteed that the concentration of ethanol obtained through continuous rectification separation is larger than or equal to 95%, the content of ethyl alcohol in a liquid mixture with ethyl alcohol removed is lower than 100 ppm, the content of salicylic acid in the liquid mixture with salicylic acid removed is lower than 3 g / L, and the purity of recycled solid salicylic acid reaches 95% or above. The method has the advantages of simple process, simple device, high product purity and the like.

Description

【Technical field】 [0001] The invention belongs to the field of chemical separation, and in particular relates to a continuous ethanol recovery and salicylic acid removal process of carbasalate calcium mother liquor. 【Background technique】 [0002] Carbasalate calcium is a chelate of calcium acetylsalicylate (calcium salt of aspirin) and urea. It is a derivative of aspirin. Its curative effect is the same as that of aspirin. Clinically, it is an analgesic, antipyretic and anti-inflammatory drug, and also a platelet aggregation inhibitor. [0003] Salicylic acid (Salicylic acid), also known as 2-hydroxybenzoic acid (English name 2-hydroxybenzonecarboxylic acid), is white needle-like crystals or hairy crystalline powder, slightly yellow and pink are allowed, easily soluble in ethanol, ether, Chloroform, slightly soluble in water, soluble in boiling water, stable at room temperature, decomposed into phenol and carbon dioxide by rapid heating, with partial acidity. Clinically, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C29/80C07C31/08C07C51/44C07C65/10
CPCC07C29/80C07C51/44C07C31/08C07C65/10
Inventor 崔培哲朱兆友王英龙李鑫孟凡庆齐建光马艺心夏丙堃
Owner QINGDAO UNIV OF SCI & TECH
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