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Polyacetylene alcohol effective part industrial extraction and purification technology

A technology of polyacetylene alcohol and effective parts is applied in the field of extraction and purification of modern traditional Chinese medicine, which can solve the problems of toxic solvent residues, cumbersome separation process, unsuitability, etc., and achieves the effects of short separation time, clean process and short duration.

Inactive Publication Date: 2019-12-03
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the extraction and purification of polyacetylene alcohols mainly use ethyl acetate, dichloromethane, chloroform conventional fat-soluble organic solvents and CO2 supercritical fluid extraction method to extract and separate, and the finer separation method is mainly through silica gel column chromatography. These extraction and separation methods are either due to the use of organic solvents (such as ethyl acetate, dichloromethane, chloroform, etc.) as eluents in solvent extraction and silica gel column chromatography, or the use of a large number of non-polyacetylenes during the extraction process. Impurities, there are problems such as cumbersome separation process, low yield, and toxic solvent residue, so it is not suitable for industrial production for the purpose of food, functional food and Chinese patent medicine production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Industrialized production of the effective part of windproof polyacetylene alcohol

[0019] 1.1 Raw materials and reagents

[0020] Raw material: Fangfeng, root of Umbelliferae plant Fangfeng, origin Inner Mongolia.

[0021] Reagents: ethanol, water, D101 macroporous adsorption resin.

[0022] 1.2 Production process

[0023] (1) Extraction of windproof polyacetylene alcohol

[0024] Take 1.0 tons of Fangfeng, crush it, and place it in an extraction tank. Ultrasonic extraction was performed twice with 70% ethanol at a solid-liquid ratio of 1:10, each time for 0.5 hours. The ethanol extract was collected, and the ethanol was recovered under reduced pressure to obtain a concentrated solution. Add 10 times the amount of water to disperse and dissolve the concentrate, centrifuge, and use the supernatant as the sample solution for further separation.

[0025] (2) Sample loading

[0026] The pretreated D 101 macroporous resin was wet packed into the column...

Embodiment 2

[0031] Example 2: Industrialized production of effective parts of ginseng polyacetylene alcohol

[0032] 1.1 Raw materials and reagents

[0033] Raw materials: 4-year-old ginseng whiskers, dried fibrous roots of Araliaceae ginseng, from Fusong.

[0034] Reagents: ethanol, water, D101 macroporous adsorption resin.

[0035] 1.2 Production process

[0036] (1) Extraction of ginseng polyacetylene alcohol

[0037] Take 1.0 tons of ginseng silk, crush it, and place it in an extraction tank. Ultrasonic extraction was performed twice with 85% ethanol at a solid-liquid ratio of 1:10, each time for 0.5 hours. The ethanol extract was collected, and the ethanol was recovered under reduced pressure to obtain a concentrated solution. Add 10 times the amount of water to disperse and dissolve the concentrate, centrifuge, and use the supernatant as the sample solution for further separation.

[0038] (2) Sample loading

[0039] The pretreated D 101 macroporous resin was wet packed into ...

Embodiment 3

[0044] Example 3: Industrialized production of effective fractions of carrot polyacetylene alcohol

[0045] 1.1 Raw materials and reagents

[0046] Ingredients: fresh carrots.

[0047] Reagents: ethanol, water, D101 macroporous adsorption resin.

[0048] 1.2 Production process

[0049] (1) Extraction of carrot polyacetylene alcohol

[0050] Take 1.0 tons of carrots, crush them, and place them in an extraction tank. Ultrasonic extraction was performed twice with 95% ethanol at a ratio of solid to liquid of 1:10, each time for 40 minutes. The ethanol extract is collected, the ethanol is recovered under reduced pressure until the concentrate has no alcohol smell, and the carrot polyacetylene alcohol extract is obtained.

[0051] (2) Sample loading

[0052] The pretreated D 101 macroporous resin was wet-packed, and 5 times the column volume of carrot polyacetylene alcohol extract was passed through the resin for dynamic adsorption at a constant flow rate.

[0053] (3) Eluti...

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Abstract

The invention relates to a modern traditional Chinese medicine extraction and purification technology, in particular relates to a traditional Chinese medicine polyacetylene alcohol effective part (containing polyacetylene alcohol components such as panaxynol / falcarinol, panaxydol, falcarindiol and 3-acetyl falcarindiol ester) clean, fast and efficient industrial extraction and purification technology. According to the traditional Chinese medicine polyacetylene alcohol effective part industrial production process, fast, clean and efficient industrial production can be performed on ginseng, roots of American ginseng, radix notoginseng, schefflera octophylla, caulis et folium hederae sinensis, acanthopanax root, sessileflower acanthopanax bark and the like of araliaceae, radix saposhnikoviae,parsnip, carrots, celeries, fennels and the like of umbelliferae, rhizoma atractylodis, rhizoma atractylodis macrocephalae, fructus arctii, herba artemisiae annuae and the like of compositae, radix platycodi, radix codonopsis, codonopsis lanceolata and the like of campanulaceae and flos caryophylli, fructus ligustri lucidi and the like of oleaceae, and a content sum of the polyacetylene alcohol components in various polyacetylene alcohol effective parts is greater than or equal to 50 percent. According to the process, development and application of the polyacetylene alcohol components in thefields of foods, functional foods and Chinese patent medicines are promoted.

Description

technical field [0001] The present invention relates to modern Chinese medicine extraction and purification technology, in particular to a polyacetylene alcohol active part of traditional Chinese medicine (including polyacetylene alcohol components such as ginseng alcohol / falveol, ginseng epoxy acetylenic alcohol, falzenediol, 3 -Acetyl falgentiol ester, etc.) clean, rapid and efficient industrial extraction and purification technology. Background technique [0002] Polyacetylenes are a class of natural products that widely exist in nature. This type of compound has two or more conjugated carbon-carbon triple bonds in its structure, and the structure contains more hydroxyl groups, so it is also called polyacetylene alcohols. (Polyacetylenols). Its unique structure makes this kind of natural products have a wide range of biological activities, such as anti-tumor, anti-inflammation, inhibition of pancreatic lipase, PPARδ receptor agonism, neurotoxicity, sedation, immunosuppre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K36/25A61K36/254A61K36/238A61K36/23A61K36/284A61K36/28A61K36/282A61K36/346A61K36/344A61K36/638A23L33/105
CPCA23V2002/00A61K36/23A61K36/238A61K36/25A61K36/254A61K36/258A61K36/28A61K36/282A61K36/284A61K36/344A61K36/346A61K36/638A61K2236/333A61K2236/51A61K2236/55A23L33/105A23V2250/21A23V2300/14
Inventor 赵岩孙夏霖李有宝张羽王清博王玉珍李延军毛欣欣
Owner JILIN AGRICULTURAL UNIV
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