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Nosiheptide soluble powder and preparation method thereof

A nosiheptide, soluble technology, applied in the field of nosiheptide soluble powder and its preparation, can solve the problems of non-soluble nosiheptide difficult to dissolve and absorb, low dose of nosiheptide, low bioavailability, etc., to achieve good absorption The effect of utilization, improvement of bioavailability, and simple preparation process

Pending Publication Date: 2019-12-17
上海莫息生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are only two types of formulations, nosiheptide premix and granules, on the market. The main problem of this type of product is that it is difficult to mix evenly due to the low dosage of nosiheptide when using the mixture, and the insoluble nosiheptide is in the It is difficult to dissolve and absorb in animals, resulting in low bioavailability

Method used

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  • Nosiheptide soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048]The carrier is selected from hydroxypropyl-β-cyclodextrin and polyamide-amine, the cosolvent is selected from poloxamer 188 and PVPK30, and the stabilizer is selected from vitamin E.

[0049] The preparation method of nosiheptide soluble powder is:

[0050] (1) Take 34.5 parts of hydroxypropyl-β-cyclodextrin, take 15.0 parts of poloxamer 188, 15.0 parts of PVPK30, weigh 34.5 parts of polyamide-amine, and 1.0 parts of vitamin E, and dissolve them in water to obtain a mixed solution .

[0051] (2) Add 0.5 part of nosiheptide to the above mixed solution, and dissolve;

[0052] (3) spray drying.

[0053] The Nosiheptide soluble powder obtained in this example has a solubility of Nosiheptide in water of 2.2% at room temperature.

Embodiment 2

[0055] The carrier is selected from hydroxypropyl-β-cyclodextrin, the cosolvent is selected from poloxamer 188 and PVPK30, and the stabilizer is selected from vitamin E and L-cystine.

[0056] The preparation method of nosiheptide soluble powder is:

[0057] (1) Take 69 parts of hydroxypropyl-β-cyclodextrin, take 10.0 parts of poloxamer 188, 20.0 parts of PVPK30, and 1.0 parts of vitamin E, and dissolve them in water to obtain a mixed solution.

[0058] (2) Add 1.0 parts of nosiheptide to the above mixed solution, and dissolve;

[0059] (3) spray drying.

[0060] The Nosiheptide soluble powder obtained in this example has a solubility of Nosiheptide in water of 2% at room temperature.

Embodiment 3

[0062] The carrier is selected from hydroxypropyl-β-cyclodextrin and polyamide-amine, the cosolvent is selected from poloxamer 188 and PVPK30, and the stabilizer is selected from vitamin C and L-cystine.

[0063] The preparation method of nosiheptide soluble powder is:

[0064] (1) Take 40 parts of hydroxypropyl-β-cyclodextrin, 28 parts of polyamide-amine, 17 parts of poloxamer 188, 13 parts of PVPK30, 1.0 parts of vitamin C, 1.0 parts of L-cystine, and dissolve in water to obtain a mixed solution.

[0065] (2) Add 1.5 parts of nosiheptide to the above mixed solution, and dissolve;

[0066] (3) spray drying.

[0067] The nosiheptide soluble powder obtained in this example has a solubility of nosiheptide in water of 2.1% at room temperature.

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Abstract

The invention provides nosiheptide soluble powder and a preparation method thereof. The nosiheptide soluble powder comprises nosiheptide, a carrier and a cosolvent. The cosolvent is one or more of poloxamer, polyvinylpyrrolidone, polyethylene glycol, sodium deoxycholate and polysorbate. The cosolvent selected in the invention has excellent physiological inertness and excellent biocompatibility. Thereby, nosiheptide can be uniformly dissolved in water to form a clear and uniform solution which can be better absorbed and utilized, and the bioavailability is improved. The selected one or more carrier components ensure that the nosiheptide soluble powder has higher solubility at normal temperature, so that the solubility of the nosiheptide at normal temperature can reach 2%. The preparation method of the nosiheptide water-soluble powder provided by the invention has the advantages of conventional equipment and simple preparation process, and is suitable for industrial mass production.

Description

technical field [0001] The invention relates to a veterinary drug preparation and a preparation method thereof, in particular to a nosiheptide soluble powder and a preparation method thereof. Background technique [0002] Nosiheptide is a sulfur-containing polypeptide antibiotic, and it is a special antibiotic for animals. Nosiheptide has high activity against Gram-positive bacteria, especially Staphylococcus, Bacillus subtilis and Clostridium wilsonii. sensitive. It has a narrow antibacterial spectrum against Gram-negative bacteria. Compared with products of the same category, Nosiheptide also has a very good antiviral effect. The mechanism of action of nosiheptide is mainly to hinder the synthesis of bacterial protein by inhibiting ribosomes, inhibit the growth of harmful bacteria in the intestine, greatly enhance the absorption function of the intestinal wall, promote animal growth, and improve feed utilization. It is widely used in clinical practice. . [0003] At pre...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K9/14A61K47/32A61K47/10A61K47/28A61K47/26A61P31/04
CPCA61K38/08A61K9/146A61K9/145A61P31/04
Inventor 马承国王磊陆静夏胜东
Owner 上海莫息生物科技有限公司
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