Preparation method of imidazolium salt antibacterial polymer

A technology of polymers and salts, applied in botany equipment and methods, chemicals for biological control, animal repellants, etc., can solve negative effects, silver wound dressings are expensive, worry about nanoparticles absorbing nanoparticles Toxicity and other issues, to achieve good biocompatibility, low cytotoxicity, and simple preparation process

Inactive Publication Date: 2019-12-20
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

While the broad-spectrum antibacterial efficacy of this dressing has been demonstrated, several studies have also reported cytotoxic effects of silver on mammalian cells and n...

Method used

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  • Preparation method of imidazolium salt antibacterial polymer
  • Preparation method of imidazolium salt antibacterial polymer

Examples

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Embodiment 1

[0021] Add 2.25ml of 1,4-butanediamine into a round bottom flask, dissolve it with 11.25ml of deionized water, and react at room temperature for 1h. Subsequently, under an ice bath at 0°C, 7.5 g of furoic acid was added, and after it was completely dissolved, 2.55 ml of glyoxal and 1.58 ml of formaldehyde were added respectively. Then use a pH meter to measure the pH value of the solution at this time, and stabilize it at about 7 by adding NaOH solution or HCL solution dropwise. After the adjustment, the temperature of the oil bath was raised to 100° C., and the reaction was continued for 36 hours. After the reaction was completed, the solution was transferred to a dialysis bag and dialyzed for 24 hours to remove unreacted raw materials. After the dialysis, the solution was put into a -80°C refrigerator for freezing, and then put into a freeze dryer for freeze-drying to obtain a dark yellow imidazolium salt antibacterial polymer.

Embodiment 2

[0023] Add 3.95ml of 1,6-hexanediamine into a round bottom flask, dissolve it with 19.75ml of deionized water, and react at room temperature for 1h. Subsequently, 8.3 g of furoic acid was added under an ice bath at 0° C., and after it was completely dissolved, 2.55 ml of glyoxal and 1.58 ml of formaldehyde were added respectively. Then use a pH meter to measure the pH value of the solution at this time, and stabilize it at about 7 by adding NaOH solution or HCL solution dropwise. After the adjustment, the temperature of the oil bath was raised to 100° C., and the reaction was continued for 36 hours. After the reaction was completed, the solution was transferred to a dialysis bag and dialyzed for 24 hours to remove unreacted raw materials. After the dialysis, the solution was put into a -80°C refrigerator for freezing, and then put into a freeze dryer for freeze-drying to obtain a dark yellow imidazolium salt antibacterial polymer.

Embodiment 3

[0025] Add 4.41ml of 1,8-octanediamine into the round bottom flask, dissolve it with 22ml of deionized water, and react at room temperature for 1h. Subsequently, 6.9 g of furoic acid was added under an ice bath at 0° C., and after it was completely dissolved, 2.55 ml of glyoxal and 1.58 ml of formaldehyde were added respectively. Then use a pH meter to measure the pH value of the solution at this time, and stabilize it at about 7 by adding NaOH solution or HCL solution dropwise. After the adjustment, the temperature of the oil bath was raised to 100° C., and the reaction was continued for 36 hours. After the reaction was completed, the solution was transferred to a dialysis bag and dialyzed for 24 hours to remove unreacted raw materials. After the dialysis, the solution was put into a -80°C refrigerator for freezing, and then put into a freeze dryer for freeze-drying to obtain a dark yellow imidazolium salt antibacterial polymer.

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Abstract

The invention relates to the field of pharmacy and in particular relates to a preparation method and application of an imidazolium salt antibacterial polymer. The preparation method comprises the following steps: dissolving an amido-containing polymer into a solution of formaldehyde and glyoxal, adding an organic carboxylic acid to regulate the pH value, and carrying out an oil bath reaction; andafter the reaction is finished, transferring the solution to a dialysis bag, and performing dialyzing and freeze-drying. The antibacterial polymer which is provided by the invention and contains the main chain imidazolium salt is synthesized by a one-pot method, the preparation process is simple and convenient, and the yield is high. In addition, staphylococcus aureus and escherichia coli are usedfor carrying out antibacterial performance testing on the polymer. Results show that the antibacterial polymer has a rapid sterilization function and can also maintain good biocompatibility. The prepared imidazolium salt antibacterial polymer has the potential of being applied to functional treatment of antibacterial dressings in biomedical materials.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of an imidazolium salt antibacterial polymer. Background technique [0002] In recent years, a number of antimicrobial agents have been used in antimicrobial wound dressings. Most commercial suppliers now offer silver coating or nanoparticle impregnation. While the broad-spectrum antimicrobial efficacy of this dressing has been demonstrated, several studies have also reported cytotoxic effects of silver on mammalian cells and negative effects on the wound-healing process. In addition, silver wound dressings are expensive, and there are ongoing concerns about nanoparticle absorption and nanoparticle toxicity. Therefore, imidazolium salts have attracted great interest as inexpensive and nontoxic antibacterial agents. [0003] Many natural products, especially alkaloids, contain imidazolium rings. Imidazolium salts are derived from 1,3-C 3 N 2 ring comp...

Claims

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Application Information

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IPC IPC(8): C08G73/06A61L15/26A61L15/46A01N43/50A01P1/00
CPCA01N43/50A61L15/26A61L15/46C08G73/0616
Inventor 周超生程钜邓林红刘博
Owner CHANGZHOU UNIV
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