Naru-3 sustained-release micro-capsule sphere and preparation method thereof

A small ball, slow-release technology, applied in microcapsules, pharmaceutical formulations, capsule delivery, etc., can solve the problem of not being able to fundamentally control the drug release rate, achieve individualized drug administration, simple and fast preparation methods, and improve drug intake. compliance effect

Pending Publication Date: 2019-12-24
INNER MONGOLIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this patent application, although the Naru-3 cataplasm has a certain delayed drug release time, because it needs to be absorbed through the skin, its release rate is passively controlled, and the absorption rate of different age groups is different, so it cannot fundamentally control drug release rate

Method used

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  • Naru-3 sustained-release micro-capsule sphere and preparation method thereof
  • Naru-3 sustained-release micro-capsule sphere and preparation method thereof
  • Naru-3 sustained-release micro-capsule sphere and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032]A prescription for Naru-3 sustained-release microcapsules, the components are expressed in mass fractions, including 20% ​​of capsule core Naru-3 extract powder, 60% of polymer capsule material ethyl cellulose, plasticized and pore-forming Agent polyvinylpyrrolidone 18%, anti-sticking agent micro-powder silica gel 2%;

[0033] Among them, the ethyl cellulose is ethyl cellulose N20 produced by Guangzhou Daojun Biotechnology Co., Ltd.; the polyvinylpyrrolidone is povidone k30 produced by Dongying Huaan Chemical Co., Ltd. Polyvinylpyrrolidone and micropowder silica gel are produced by Tianjin Yongsheng Fine Chemical Co., Ltd.

Embodiment 2

[0035] A prescription for Naru-3 sustained-release microcapsules, the components are expressed in mass fractions, including 22% of capsule core Naru-3 extract powder, 54% of polymer capsule material ethyl cellulose, plasticized and pore-forming Agent glycerin 22%, anti-tack agent talcum powder 2%;

[0036] Ethyl cellulose is the ethyl cellulose of ethyl cellulose N100 that the model produced by Guangzhou Daojun Biotechnology Co., Ltd.; Talcum powder is produced by Tianjin Damao Chemical Reagent Factory.

Embodiment 3

[0038] A Naru-3 sustained-release microcapsule prescription, the components are in mass fraction, including 18% of the capsule core Naru-3 extract powder, 54% of polymer capsule material acrylic resin, plasticizing porogen poly Ethylene glycol 27%, anti-sticking agent micro-powder silica gel 2%;

[0039] Wherein, acrylic resin is the acrylic resin of Eudragit RL100 produced by Colorcon Company; Polyethylene Glycol is the Polyethylene Glycol of PEG6000 produced by Tianjin Fuchen Chemical Reagent Factory.

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Abstract

The invention discloses a naru-3 sustained-release micro-capsule sphere which comprises capsule core material naru-3 extract powder, a polymer capsule material and an auxiliary material, and the weight ratio of the sum of the weight of the polymer capsule material and the auxiliary material to the weight of the naru-3 extract powder is (1 to 4): 1; and the invention further discloses a preparationmethod of the naru-3 sustained-release micro-capsule sphere. The preparation method comprises the following steps: S1, preparing naru-3 liquid medicine; S2, preparing a coating solution; and S3, preparing the naru-3 sustained-release micro-capsule sphere. Physical changes exist in the process of preparing the naru-3 sustained-release micro-capsule sphere by using a spray drying method; propertiesof drugs are not destroyed, the preparation method is simple, convenient, fast, economical and applicable and can be suitable for industrial production, and auxiliary materials are non-toxic and harmless, so that the safety of a medicinal preparation is guaranteed, the peak concentration of medicinal components can be remarkably reduced by the prepared naru-3 sustained-release micro-capsule sphere, and drug poisoning caused by a relatively large peak value of a drug in a body is avoided, so that the action time of effective components is prolonged, and the difference of medicine taking amongindividuals is reduced.

Description

Technical field: [0001] The invention relates to a microcapsule and a preparation method thereof, in particular to a Naru-3 sustained-release microcapsule and a preparation method thereof. Background technique: [0002] Naru-3 is a common prescription of Mongolian medicine for treating rheumatoid arthritis. According to the 1998 edition of the Pharmacopoeia Committee of the People's Republic of China "Drug Standards of the Ministry of Health of the People's Republic of China Mongolian Medicine Sub-volume", it is mainly composed of Myrobalan, Piper longum, and Aconitum japonicus. Composed of three medicinal materials, its nature, flavor and function are coordinated with each other. It is warm in nature and has the functions of dispelling yellow water, killing "stickiness", reducing swelling and relieving pain. It is mainly used for joint pain, yellow water disease and waist and leg pain. The preferred prescription for water sickness. Indications for rheumatism, joint pain, c...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/52A61K47/38A61K47/32A61K47/04A61P29/00A61P17/06
CPCA61K9/501A61K9/5026A61K9/5042A61K36/185A61K36/67A61K36/714A61P17/06A61P29/00A61K2300/00
Inventor 顾艳丽
Owner INNER MONGOLIA MEDICAL UNIV
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