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Luminescent nanoparticles that can be enriched in animal skin and preparation method thereof

A nanoparticle and nanotechnology, which is applied in the field of luminescent nanoparticles that can be enriched in animal skin and its preparation, can solve the problems of shallow penetration depth, inability to respond to ultraviolet rays, and inability to achieve controlled release of drugs, and achieve good applications. Value, significant creativity, effect of excellent skin enrichment ability

Active Publication Date: 2020-11-03
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the shallow penetration depth of ultraviolet and visible light, nanoparticles located in deep tissues and organs cannot respond to ultraviolet and visible light stimulation, so the purpose of controlled release of drugs cannot be achieved.

Method used

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  • Luminescent nanoparticles that can be enriched in animal skin and preparation method thereof
  • Luminescent nanoparticles that can be enriched in animal skin and preparation method thereof
  • Luminescent nanoparticles that can be enriched in animal skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1, the surface that the average particle diameter is 13.9 nanometers is modified styrene-maleic acid copolymer and Eu(tta) by albumin 3 Preparation of complex nanoparticles formed by bpt and its enrichment properties in skin

[0050] Weigh 1.0mg Eu(tta) 3 The bpt complex and 10.0 mg of styrene-maleic acid copolymer (partial isobutyl esterification, Mw ~ 65,000) were dissolved in 35.0 mL of acetone, and the above-mentioned acetone The solution is mixed with water and the vacuum is 0.09 MPa. The acetone in the mixed solution was rotary evaporated under reduced pressure at 35°C (vacuum degree is 0.09 MPa), and the resulting colloidal solution was heated to reflux at 100°C for 1 hour to obtain a mixture of styrene-maleic acid copolymer and europium ion Colloidal solution of composite nanoparticles (referred to as Eubpt@SMAH-S) composed of organic sensitized rare earth light-emitting ligands bpt and tta. The dynamic light scattering test results show that the n...

Embodiment 2

[0059] Embodiment 2, the number-average particle diameter is the styrene-maleic acid copolymer and Eu(tta) that the surface is modified by albumin of 53.6 nanometers 3 Preparation of complex nanoparticles formed by bpt and its enrichment properties in skin

[0060] According to the preparation method and conditions in Example 1, the volume of acetone was changed to 2 milliliters to obtain a number-average particle diameter of 47.6 nanometers composed of styrene-maleic acid copolymer, europium ions and organic sensitized rare earth light-emitting ligand bpt and tta composite nanoparticles (denoted as Eubpt@SMAH-L), the particle size distribution range is 42-52 nanometers. Under the condition of stirring in a water bath at 35°C, add 160 mL of a colloidal solution containing 11.0 mg of Eudpbt@SMAH-L nanoparticles to an aqueous solution of albumin (5.0 mL, 2.0 mg / mL), and stir at room temperature for 2 hours to obtain the number average particle diameter Eubpt@SMAH-L nanoparticle...

Embodiment 3

[0063] Embodiment 3, the surface is modified by albumin by styrene-maleic acid copolymer and Eu(fod) 3 Preparation of DPBT-formed composite nanoparticles

[0064] Weigh 0.3mg Eu(fod) 3 The dpbt complex and 10.0 mg of styrene-maleic acid copolymer (partially isobutylated, Mw ~ 65,000) were dissolved in 40.0 mL of THF, and the above THF solution was mixed with water at room temperature using a decompression-induced microfluidic mixing device , under reduced pressure at 35°C, the tetrahydrofuran in the mixed solution was evaporated under reduced pressure; the obtained colloidal solution was heated to reflux at 100°C for 1 hour, and a luminescent complex composed of styrene-maleic acid copolymer, europium ion and organic sensitized rare earth was obtained. Colloidal solution of composite nanoparticles (referred to as Eudpbt@SMAH) composed of body dpbt and fod. The dynamic light scattering test results showed that the prepared Eudpbt@SMAH nanoparticles had a number-average partic...

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Abstract

The invention discloses a luminescent nanoparticle capable of being enriched on animal skins, and a preparation method thereof. The nanoparticle is a compound nanoparticle modified with albumin on thesurface and composed of a styrene-maleic acid copolymer, rare earth ions and an organic sensitized rare earth luminescent ligand, and the number-average particle size of the nanoparticle is 8-100 nm.The nanoparticle provided by the invention has application values in the fields of skin administration, controllable release of drugs and in-vivo imaging.

Description

technical field [0001] The invention relates to a class of luminescent nanoparticles that can be enriched in animal skin, a preparation method thereof, and an application as a nanometer drug carrier. Background technique [0002] As the largest organ of the human body and the first line of defense, the skin undertakes the functions of protecting internal tissues and organs, sweating, sensing temperature and pressure, and protecting various organs from physical, chemical, mechanical and pathogenic microorganisms. . Skin diseases affect the skin's defenses against the body. Therefore, the treatment and diagnosis of skin diseases are of great significance for ensuring the health of the body. [0003] As we all know, since the skin is exposed to the surface of the body, the clinical commonly used chemical means for skin disease treatment are mainly external application. However, due to the barrier effect of the skin, the deep penetration of externally applied drugs is hindere...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C07F5/00C09K11/06B82Y20/00B82Y30/00B82Y40/00A61K49/00A61K9/51A61K47/34A61K47/42
CPCA61K9/5146A61K9/5169A61K49/0021A61K49/0054A61K49/0056A61K49/0093B82Y20/00B82Y30/00B82Y40/00C09K11/025C09K11/06C09K2211/182
Inventor 王远高智悦王川西柯灿
Owner PEKING UNIV