Tough and adherent wet tissue hydrogel dressing box and preparation method and application thereof

Abstract

The invention provides a tough and adherent wet tissue hydrogel dressing box. The tough and adherent wet tissue hydrogel dressing box comprises two components stored separately, wherein the componentA is hydrogel formed by crosslinking sodium alginate and acrylamide, and the component B is a coupling solution prepared from the raw materials of a coupling agent, a linking agent and a buffer solution. The hydrogel dressing box is convenient to use. By adding the component B, the adhesive performance of a hydrogel dressing is significantly improved, and the hydrogel dressing has high adhesion strength to the skin surface and the surface of wet tissue in the body, is not prone to falling off and meets clinical demand. Meanwhile, the hydrogel dressing has excellent mechanical properties and biocompatibility and can be degraded. In addition, the dressing has the water content of up to 86%, can be loaded with a large number of drugs, can provide a good environment for tissue recovery and promote tissue healing. The tough and adherent wet tissue hydrogel dressing box not only solves the problems that traditional dressings have poor treatment effects of wounds and cannot be degraded and the like, but also solves the problem of poor adhesion performance of novel dressings, can further be applied to tissue in vivo, and has broad application prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a tough and adherent wet tissue hydrogel dressing box as well as its preparation method and application. Background technique [0002] Wound healing refers to the healing process after the body is subjected to external forces, and internal and external tissues such as the liver and skin are severed or damaged; the pathophysiological process of tissue regeneration and remodeling after an inflammatory response is an extremely complex mechanism. At present, wound dressings are mostly used to treat wounds to resist external microbial infection, reduce body fluid and heat loss from damaged wounds, and accelerate wound healing. Traditional dressings represented by gauze, bandages, and cotton pads are the most widely used. They are cheap, but they are non-degradable, easy to adhere to the wound, difficult to maintain long-term efficacy, and the dressing process will incre...

AI Technical Summary

Problems solved by technology

[0003] Although the repair effect of these new dressings has been improved, their adhesion performance is often poor, and even cannot meet the clinical needs

For example, Se'verine Rose et al. select nano-SiO with high concentration (30wt%-50wt%) 2 Particle solutions can achieve low adhesion to wetted surfaces through physical action, but cannot meet surgical requirements (Rose S, Prevoteau A, Elzière P, et al. Nature, 2014, 505, 382.)

Some new dressings enhance the adhesion with the tissue by adding adhesives to the dressing, but these adhesives have poor adhesion to the dressing, such as commercial fibrin glue and polyethylene glycol adhesives Can form covalent bonds with tissues (Dastjerdi A K, Pagano M, Kaartinen M T, etal. Acta Biomaterialia, 2012, 8, 3349.), which greatly enhances the adhesion, but lacks sufficient force with the dressing, and the dressing is easy to debond

At the same time, the existing dressings are mostly used for skin healing, and the healing effect on the surface of wet tissues in the body is relatively poor.

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