Temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material and preparation method thereof

A nano-hydroxyapatite, polyamino acid technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve problems such as material remodeling, and achieve good biological activity.

Inactive Publication Date: 2020-01-03
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the amino acid polymer-hydroxyapatite repair material in the prior art has excellent mechanical properties, it is difficult to reshape the material after molding

Method used

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  • Temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material and preparation method thereof
  • Temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material and preparation method thereof
  • Temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Preparation of nano-hydroxyapatite polyamino acid composite bone graft material of the present invention

[0058] Weigh 116.16g of ζ-aminoheptanoic acid, 13.1g of hydroxyproline, 5.85g of lysine, and 9.91g of phenylalanine respectively, put them into a 250mL three-necked bottle, add 50mL of distilled water, protect with nitrogen, stir and heat up Dehydrate at 180°C (you can judge whether the dehydration treatment has been completed by observing whether the amino acid begins to melt). After dehydration is completed, continue to heat up to 210°C, pre-polymerize for 1 hour in a molten state, then continue to heat up to 220°C for polymerization for 3 hours, complete the first-stage reaction, and obtain the polyamino acid molecular chain shown in the aforementioned formula II;

[0059] The straight-chain amino acids in the reaction are (m=6, ζ-aminoheptanoic acid), with a reactive side group R 1 The amino acid is (hydroxyproline) and (Lysine), with inert or ...

Embodiment 2

[0064] Example 2 Preparation of nano-hydroxyapatite polyamino acid composite bone graft material of the present invention

[0065] Weigh 117.9g of ε-aminocaproic acid, 6.55g of hydroxyproline, and 8.26g of phenylalanine respectively, put them into a 250mL three-necked bottle, add 50mL of distilled water, protect with nitrogen, stir and heat up to 180°C for dehydration (can be Whether the dehydration treatment has been completed can be judged by observing whether the amino acid begins to melt). After dehydration is completed, continue to heat up to 210°C, pre-polymerize for 1 hour in a molten state, then continue to heat up to 220°C for polymerization for 3 hours, complete the first-stage reaction, and obtain the polyamino acid molecular chain shown in the aforementioned formula II;

[0066] The straight-chain amino acids in the reaction are (m=5, ε-aminocaproic acid), with a reactive side group R 1 The amino acid is (Hydroxyproline), with inert or carboxylic side groups R...

Embodiment 3

[0071] Example 3 Preparation of nano-hydroxyapatite polyamino acid composite bone graft material of the present invention

[0072] Weigh 117.9g of ε-aminocaproic acid, 5.85g of lysine, and 9.91g of phenylalanine respectively, put them into a 250mL three-necked bottle, add 50mL of distilled water, protect with nitrogen, stir and heat up to 180°C for dehydration (can be dehydrated by Whether the dehydration treatment has been completed can be judged by observing whether the amino acid begins to melt). After dehydration is completed, continue to heat up to 210°C, pre-polymerize for 1 hour in a molten state, then continue to heat up to 220°C for polymerization for 3 hours, complete the first-stage reaction, and obtain the polyamino acid molecular chain shown in the aforementioned formula II;

[0073] The straight-chain amino acids in the reaction are (m=5, ε-aminocaproic acid), with a reactive side group R 1 The amino acid is (Lysine), with inert or carboxylic side groups R ...

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Abstract

The invention discloses a temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material. The temperature and modulus dual-controlled nano-hydroxyapatiteand polyamino acid composite bone graft material is formed by polyamino acid and nano-hydroxyapatite in an in-situ composting mode, and the structure of the temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material is shown as a formula (I) (please see the specifications for the formula (I)). The invention further provides a preparation method andapplication of the composite bone graft material. The temperature and modulus dual-controlled nano-hydroxyapatite and polyamino acid composite bone graft material comprising a bionic structure and prepared through the preparation method has the mechanical property approaching to that of human bones and has the deformation temperature and elasticity modulus which can be adjusted and controlled; secondary modeling is easy to be conducted, the material shape is adjusted immediately and conveniently according to the demands of patients in clinical use, and quick injection moulding can further beachieved; good biological activity, good biocompatibility and good biosecurity are achieved; and the proper thermal deformation temperature and mechanical properties can be selected according to the different clinical needs, and the temperature and modulus dual-controlled nano-hydroxyapatite polyamino acid composite bone graft material is clinically suitable for supporting of bone repair and reconstruction and supporting and repairing of immediate modeling of certain complex and irregular wounds.

Description

technical field [0001] The invention relates to a medical composite material that can be used as a load-bearing bone repair and reconstruction, in particular to a temperature- and modulus-controlled nano-hydroxyapatite polyamino acid composite bone graft material and a preparation method thereof. Background technique [0002] The main components of human bone tissue include water, organic matter and inorganic salts, etc. Compared with other tissues and organs, the water content in bones is less. Among the remaining solid matter, about 40% are organic matter (collagen), and 60% are inorganic salts (apatite). Bone tissue can be regarded as a composite material composed of organic matter and inorganic salts. The inorganic salts in bones are mainly crystalline hydroxyapatite and amorphous calcium phosphate, etc. These inorganic salt components determine the hardness of bones. Most of the organic matter is collagen, and the rest are other protein peptides and lipids such as glyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/50C08G69/10C08J3/24C08L77/04
CPCA61L27/46A61L27/50A61L2430/02A61L2430/38C08G69/10C08J3/24C08J2377/04C08L77/04
Inventor 严永刚邓光进戢觅之
Owner 中鼎凯瑞科技成都有限公司
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