Method for extracting octacosanol from sugarcane wax on sugarcane skin

A technology of octacosanol and sucrose wax, which is applied in the field of pharmaceutical preparation, can solve the problems of increased use of organic solvents, easy fermentation, and easy entry of impurities into end products, and achieves simple extraction process, short production cycle, and good appearance quality Effect

Inactive Publication Date: 2020-01-24
GUANGDONG PROVINCIAL BIOENGINEERING INST (GUANGZHOU SUGARCANE IND RES INST)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the filter mud contains a large amount of water and sugar, which is easy to ferment, produces a strong smell and causes cane wax to decompose, making it difficult to store raw materials and ensure product quality; on the other hand, the presence of a large amount of impurities in the filter mud leads to The increase in the use of organic solvents and some impurities are easy to enter the end product, resulting in increased production costs, increased environmental protection pressure, and reduced and unstable product quality, especially in the application of high-end fields such as pharmaceuticals and health care products. It is difficult to accept

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for extracting high-purity octacosanol from sugarcane epidermis sucrose wax, comprising the steps of:

[0026] (1) On the sugarcane that has not been harvested, use sandpaper to scrape the wax of the sugarcane epidermis on the spot, store it in the sample bag prepared earlier, soak the sandpaper in absolute ethanol, and brush off the cane wax on the sandpaper with a brush , concentrated under reduced pressure to remove ethanol, merged with the sample in the sample bag, and dried to obtain crude cane wax;

[0027] (2) Weigh 5g of the crude cane wax obtained in step (1), place it in a 50mL round bottom flask, add 25mL of ethanol with a mass fraction of 95%, raise the temperature to 90°C and cool down to 85°C and stir after the crude cane wax is completely dissolved Heat to reflux for 1 hour, let stand to cool, then separate the solution, pour out the upper precipitate, filter with suction and wash with 95% cold ethanol for 2 to 3 times, collect the solid and dry ...

Embodiment 2

[0032] A method for extracting high-purity octacosanol from sugarcane epidermis sucrose wax, comprising the steps of:

[0033] (1) On the sugarcane that has not been harvested, use sandpaper to scrape the wax of the sugarcane epidermis on the spot, store it in the sample bag prepared earlier, soak the sandpaper in absolute ethanol, and brush off the cane wax on the sandpaper with a brush , concentrated under reduced pressure to remove ethanol, merged with the sample in the sample bag, and dried to obtain crude cane wax;

[0034] (2) Weigh 5g of the crude cane wax obtained in step (1), place it in a 50mL round bottom flask, add 30mL of ethanol with a mass fraction of 95%, heat up to 90°C and cool down to 85°C after the crude cane wax is completely dissolved and stir Heat to reflux for 1 hour, let stand to cool, then separate the solution, pour out the upper precipitate, filter with suction and wash with 95% cold ethanol for 2 to 3 times, collect the solid and dry it at 60°C for...

Embodiment 3

[0039] A method for extracting high-purity octacosanol from sugarcane epidermis sucrose wax, comprising the steps of:

[0040] (1) On the sugarcane that has not been harvested, use sandpaper to scrape the wax of the sugarcane epidermis on the spot, store it in the sample bag prepared earlier, soak the sandpaper in absolute ethanol, and brush off the cane wax on the sandpaper with a brush , concentrated under reduced pressure to remove ethanol, merged with the sample in the sample bag, and dried to obtain crude cane wax;

[0041] (2) Weigh 5g of the crude cane wax obtained in step (1), place it in a 50mL round bottom flask, add 25mL of ethanol with a mass fraction of 95%, raise the temperature to 90°C and cool down to 85°C and stir after the crude cane wax is completely dissolved Heating to reflux for 5 hours, standing to cool, and then separating the solution, pouring out the upper layer precipitate, suction filtration and washing with 95% cold ethanol for 2 to 3 times, collecti...

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Abstract

The invention discloses a method for extracting octacosanol from sugarcane wax on sugarcane skin. The method comprises: (1) scraping surface wax on the surface of un-harvested sugarcane on site to obtain crude sugarcane wax; (2) adding a first solvent into the crude sugarcane wax, carrying out heating reflux under a stirring condition, then carrying out standing cooling, carrying out suction filtration and washing, and drying to obtain refined sugarcane wax; (3) adding a second solvent and an alkali into the refined sugarcane wax, carrying out stirring reflux, cooling to 60 DEG C, adding a third solvent to obtain a mixed solution, carrying out stirring extracting, adding distilled water, stirring, carrying out standing layering, taking the upper organic layer, performing cold separation, suction filtration and water washing, and drying to obtain crude policosanol; and (4) adding the crude policosanol into a vacuum distillation device, controlling the vacuum pressure and the distillation range, and carrying out two-step distillation to obtain octacosanol. According to the invention, the obtained octacosanol has advantages of high purity, good quality and good appearance quality, andis suitable for high-end development of related products.

Description

Technical field: [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a method for extracting octacosanol from sugarcane epidermis cane wax. Background technique: [0002] Octacosanol (Octacosanol) chemical name is 1-octacosanol (1-Octacosanol) or n-octacosanol (n-Octacosanol), the common name is Montanyl alcohol (Montanyl alcohol), Japan is also known as sorghum alcohol ( Koranylalcohol), the relative molecular weight of octacosanol is 410.77, the melting point is 83.2~83.6°C (purity≥97%), the freezing point is 82.6°C, the boiling point is 175°C (2.7Pa), 190°C (10Pa), 227°C (100Pa), Specific gravity 0.783g / cm 3 (85°C). Soluble in organic solvents such as hot ethanol, ether, benzene, toluene, chloroform, dichloromethane, petroleum ether, etc., insoluble in water, and stable in acid, alkali, reducing agent, etc. [0003] Octacosanol generally exists in plants in the form of wax esters, and octacosanol is contained in pla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C27/02C07C29/80C07C31/02C11B11/00
CPCC07C29/095C07C29/80C11B11/00C07C31/02Y02W30/74
Inventor 孟飞黄俊生黄冬婷黄清铧黎鹏汤静洁
Owner GUANGDONG PROVINCIAL BIOENGINEERING INST (GUANGZHOU SUGARCANE IND RES INST)
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