Continuous crystallization method of tetracycline

A tetracycline base and tetracycline technology, applied in organic chemistry, carboxylic acid amide separation/purification, etc., can solve the problems of material handling, storage, drying workload, operator physical damage, and labor intensity, etc., to achieve The effect of shortening the solution supersaturation time, high degree of filtration automation and improving the production environment
CN110734385AInactive Publication Date: 2020-01-31NINGXIA QIYUAN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NINGXIA QIYUAN PHARMA
Publication Date
2020-01-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a continuous crystallization method of tetracycline. The method comprises the following steps of: preparing raw materials; the invention discloses a continuous crystallizationmethod of tetracycline. The method is characterized by comprising the following process steps: diluting tetracycline fermentation liquor, cooling, acidifying with oxalic acid, purifying, and filtering by using a ceramic ultrafiltration film; then directly mixing the tetracycline filtrate and ammonia water in a conveying pipeline, and continuously feeding the mixture into a reaction container forcrystallization; and when feeding is carried out for 20-40 minutes and the volume of the mixed material liquid reaches 70-80% of the volume of the reaction device, transferring the material liquid into a buffer device for continuous crystallization under the condition of continuous feeding, and after continuous crystallization of the tetracycline is completed, carrying out suction filtration and drying to obtain the tetracycline. The continuous crystallization of the tetracycline is realized, the crystallization efficiency and the product yield are greatly improved, the quality of the producedproduct is stable, the production environment is greatly improved, the production cost is reduced, and the method is an energy-saving and emission-reducing tetracycline crystallization method.
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Description

technical field

[0001] The invention belongs to the technical field of biology and new medicine, in particular to a continuous crystallization method of tetracycline base. Background technique

[0002] Tetracycline (erythromycin, Er) is a class of tetracyclic antibiotics, which have a good inhibitory effect on Gram-positive bacteria, negative bacteria, rickettsia, viral viruses, spirochetes and even protozoa, and have a good inhibitory effect on Mycobacterium tuberculosis , Proteus, etc. are invalid. Its mechanism of action is that after binding to the 30S subunit of the ribosome, it can prevent aminoacyl tRNA from binding to the ribosome.

[0003] In the prior art, the crystallization process of the tetracycline fermented liquid is as follows: after the tetracycline fermented liquid fermented and produced with Streptomyces aureus is cooled, acidified, plate and frame press filter, acid water top washing, the tetracycline filtrate (tetracycline filtrate Potency control 800...

Claims

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