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Amino sugar oral liquid and preparation method thereof

A technology of ammonia sugar oral liquid and oral liquid, which is applied in the field of medicine, can solve the problems of low effective drug content, easily oxidized and discolored amino groups, and poor stability, and achieve the effects of high effective drug content, stable quality, and improved safety

Active Publication Date: 2020-02-07
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, glucosamine has many disadvantages as a drug, such as glucosamine is highly hygroscopic, and its amino group is easily oxidized and discolored. Therefore, the preparation requirements of glucosamine are relatively high, such as tablets need to be coated, packed in Capsule shells should be sealed and protected from moisture and oxygen
In addition, most of the commercially available glucosamine products have less effective drug content, poor stability and low bioavailability

Method used

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  • Amino sugar oral liquid and preparation method thereof
  • Amino sugar oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 45 parts of glucosamine sulfate, 13 parts of rhizome polysaccharide, 12 parts of raspberry polysaccharide with a polysaccharide purity of 85% w / w, 6 parts of mint essence, 2 parts of benzoic acid, 2 parts of sodium bisulfite, 12 parts of Polyethylene glycol, 2 parts of EDTA-2Na, 3 parts of xylitol, then glucosamine, rhizome polysaccharide, raspberry polysaccharide, mint essence, benzoic acid, sodium bisulfite, polyethylene glycol, EDTA-2Na 1. Xylitol was added into deionized water, and after mixing evenly, the pH of the aqueous solution was adjusted to 6.5 with a pH regulator, and the oral liquid glucosamine was obtained after fine filtration through a microporous membrane.

Embodiment 2

[0026] Weigh 40 parts of glucosamine hydrochloride, 10 parts of rhizome polysaccharide, 8 parts of raspberry polysaccharide with a polysaccharide purity of 75% w / w, 5 parts of mint essence, 1 part of ethyl p-hydroxybenzoate, and 1 part of sodium metabisulfite , 7 parts of propylene glycol, 1 part of DTPA, 1 part of sodium saccharin, and then add glucosamine, rhizome polysaccharide, raspberry polysaccharide, mint flavor, ethyl p-hydroxybenzoate, sodium metabisulfite, propylene glycol, DTPA, sodium saccharin to deionized In water, after mixing evenly, use a pH regulator to adjust the pH of the aqueous solution to 5.5, and fine-filter through a microporous membrane to obtain the oral liquid glucosamine.

Embodiment 3

[0028] Weigh 50 parts of glucosamine sulfate, 16 parts of rhizome polysaccharides, 15 parts of raspberry polysaccharides with a polysaccharide purity of 65% w / w, 7 parts of peppermint essence, 4 parts of calcium sorbate, 2 parts of sodium bisulfite, 15 parts of 1 part of ethanol, 3 parts of NTA, 6 parts of cyclamate, then add glucosamine, rhizome polysaccharide, raspberry polysaccharide, mint flavor, calcium sorbate, sodium bisulfite, ethanol, NTA, cyclamate into deionized water, mix After uniformity, use a pH regulator to adjust the pH of the aqueous solution to 7, and fine-filter the aqueous solution through a microporous membrane to obtain the glucosamine oral liquid.

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Abstract

The invention belongs to the field of medicines, and discloses amino sugar oral liquid and a preparation method thereof. The amino sugar oral liquid comprises the components in parts by weight of 40-50 parts of glucosamine, 10-16 parts of oudemansiella radicata polysaccharide, 8-15 parts of raspberry polysaccharide, 5-7 parts of mint essence, 2-6 parts of a preservative, 7-15 parts of a solubilizer, 1-3 parts of a complexing stabilizing agent and 1-6 parts of a corrigent, wherein the pH is regulated to 5.5-7 with a pH-regulating agent. The amino sugar oral liquid contains the oudemansiella radicata polysaccharide having the medicine and pharmacology activity, and the raspberry polysaccharide having the efficacy of reducing blood sugar and resisting weariness, not only has the nutrient andhealth-care functions, but also is high in medical value and good in stability.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an ammonia sugar oral liquid and a preparation method thereof. Background technique [0002] Glucosamine is a natural amino monosaccharide, which is a physiologically active substance that can stimulate chondrocytes to produce proteoglycan and collagen with a normal multimer structure, and is an essential substance for the synthesis of proteoglycan in joints. Glucose can inhibit the enzymes that damage cartilage such as collagenase and phospholipase A2, and can prevent the production of superoxide free radicals that damage cells. At the same time, it does not inhibit the biosynthesis of prostaglandins. The pathological process of arthritis, preventing disease progression, improving joint mobility, relieving pain, and without significant side effects. Non-steroidal anti-inflammatory drugs only relieve symptoms and have no blocking effect on the process of osteoarthritis. Some drugs such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/12A61K47/02A61K31/715A61K31/7008A61P19/02A61P3/02
CPCA61K9/0095A61K31/7008A61K31/715A61K47/02A61K47/12A61P3/02A61P19/02A61K2300/00
Inventor 卢健行刘长峰王庆韩宁张建华
Owner SHANDONG RUNDE BIOTECH CO LTD
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