Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Calcium citrate/calcium sulfate composite bone cement loaded with vitamin D and its preparation method

A technology of calcium citrate and calcium sulfate, applied in the field of bone repair materials, can solve the problems of poor injectability, fast degradation, low strength, etc., and achieve the effects of good plasticity, improved cell activity, and good osteogenic ability.

Active Publication Date: 2022-05-17
中鼎凯瑞科技成都有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently clinically used bone filling materials include hydroxyapatite, calcium phosphate, calcium silicate, calcium sulfate, etc., but each of them has some problems, such as low strength, too fast or too slow degradation, poor injectability, etc. This limits its clinical application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calcium citrate/calcium sulfate composite bone cement loaded with vitamin D and its preparation method
  • Calcium citrate/calcium sulfate composite bone cement loaded with vitamin D and its preparation method
  • Calcium citrate/calcium sulfate composite bone cement loaded with vitamin D and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1- Embodiment 6

[0039] Prepare Example 1 according to the formula in Table 1, and its preparation method is: calcium citrate and calcium sulfate powder are weighed by the mass ratio in Table 1, then the composite powder after physical mixing is put into ball mill and ground 4h, The ball milling speed is 150 rpm, and then the solidified liquid is accurately measured according to the liquid-solid ratio in Table 1, wherein the solidified liquid is deionized water; the solidified liquid is added to the solid phase powder, stirred rapidly to form a bone cement slurry, and then The bone cement paste is put into a polytetrafluoroethylene mold with a diameter of 6 mm and a height of 7 mm and 12 mm for molding.

[0040] Formulation preparation example in table 1 embodiment 1-embodiment 6

[0041] Numbering Calcium Citrate / Calcium Sulfate Liquid-solid ratio (mL / g) Example 1 sample 1 0：1 0.19 Example 2 sample 2 1：4 0.21 Example 3 sample 3 2：3 0.23 Example ...

Embodiment 7- Embodiment 11

[0043] Preparation of vitamin D3-ethanol solution, weigh 1.25g of vitamin D3 powder and dissolve it in 100mL of absolute ethanol to prepare a vitamin D-ethanol solution with a concentration of 12.5mg / mL; then dilute the solution to obtain 2.5, 0.5 and 0.1mg / mL vitamin D3-ethanol solution.

[0044] Prepare Examples 7-11 according to the formula in Table 2. The preparation method is as follows: accurately weigh calcium citrate and calcium sulfate powders at a mass ratio of 3:2, and then put the physically mixed composite powder into a ball mill Grind for 4 hours, the ball milling speed is 150 rpm, and then accurately measure vitamin D3-ethanol solutions of different concentrations according to the liquid-solid ratio of 1.5mL / g (referring to the ratio of vitamin D3-ethanol solution to the composite powder), and add the solution to the compound powder Stir the powder with a magnetic stirrer for 15 minutes, then put it in a blast drying oven for 6 hours at 50°C, and finally grind th...

Embodiment 1-6

[0062] The sample solidified in the air for 3 days was ground into fine powder with a mortar, and the sample powder was analyzed by X-ray diffractometer to study the curing mechanism of the composite bone cement.

[0063] The XRD diffraction pattern when the sample is solidified for 3 days is as follows: Figure 4 , it can be seen that sample 1 is the main diffraction peak of calcium sulfate; sample 6 is the main diffraction peak of calcium citrate. Other samples were composite bone cements composed of calcium sulfate and calcium citrate. CaSO in sample 4 and sample 5 4 2H 2 The diffraction peak of O disappeared, probably because the chelation effect hindered the hydration process of calcium sulfate and inhibited the CaSO 4 2H 2 Generation of O.

[0064] 5, the situation of material degradation (the sample of embodiment 7-11):

[0065] The samples were tested for material degradation in phosphate buffered saline (PBS).

[0066] The preparation method of PBS is as follow...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
strengthaaaaaaaaaa
strengthaaaaaaaaaa
strengthaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of bone repair materials, in particular to calcium citrate / calcium sulfate composite bone cement loaded with vitamin D, its preparation method and application. The invention provides a vitamin D-loaded calcium citrate / calcium sulfate composite bone cement, the bone cement is composed of a solid phase part and a liquid phase part, and the liquid-solid ratio is 0.2-0.6:1; the solid phase part includes calcium citrate , calcium sulfate salt and vitamin D, the mass ratio of calcium citrate and calcium sulfate salt is 1:4 to 4:1; the mass ratio of vitamin D to bone cement is 6×10 ‑3 ~20×10 ‑3 :1. The composite bone cement obtained by the invention has good injectability, suitable setting time, slow drug release and excellent biological activity, and can be used for filling bone defects.

Description

technical field [0001] The invention belongs to the field of bone repair materials, in particular to calcium citrate / calcium sulfate composite bone cement loaded with vitamin D, its preparation method and application. Background technique [0002] In recent years, with the aging of the population, the incidence of various trauma and chronic diseases such as osteoporosis has increased significantly. How to effectively treat osteoporosis has become one of the hot research issues. Calcium is the main mineral element to build human bones. Calcium not only contributes to bone formation, but also activates various enzymes. 99% of calcium in the human body is stored in hard tissues such as bones and teeth, and only 1% is stored in soft tissues such as blood, internal organs, muscles, and nerves in an ionized state. Calcium deficiency can not only cause rickets, osteomalacia, and osteoporosis, but also lead to many diseases such as hypertension, arteriosclerosis, soft tissue calci...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/02A61L27/50A61L27/54
CPCA61L27/025A61L27/54A61L27/50A61L2400/06A61L2430/02A61L2300/428
Inventor 严永刚邓光进陈红戢觅之
Owner 中鼎凯瑞科技成都有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com