Preparation method of catalyst and application of catalyst in preparation of β-isophorone

Abstract

The invention provides a preparation method of a catalyst and application of the catalyst in the preparation of β-isophorone. The preparation method of the catalyst comprises: 1) esterifying β-cyclodextrin and amino acid to obtain amino acid-modified esterified β-cyclodextrin; 2) generating amino acid-modified esterified β-cyclodextrin and aromatic aldehyde A Schiff base reaction is performed to obtain a Schiff base modified esterification β-cyclodextrin catalyst. The present invention also provides a method for preparing β-isophorone by isomerizing α-isophorone under the catalysis of the Schiff base-modified esterified β-cyclodextrin prepared by the above method method. The catalyst prepared by the method of the invention has high selectivity and high yield for the reaction of α-isophorone isomerization to β-isophorone, is not easy to produce by-products, has simple operation, strong industrial applicability, and is suitable for equipment. Corrosion free.

Description

technical field [0001] The invention relates to a cyclodextrin modified catalyst, in particular to a preparation method of a cyclodextrin modified catalyst and the application of the catalyst in the preparation of beta-isophorone, belonging to the technical field of catalysts. Background technique [0002] β-Isophorone (3,5,5-trimethylcyclohex-3-en-1-one) is an important intermediate in the synthesis of vitamin E, carotenoids, astaxanthin and various spices, and is an important intermediate in the synthesis of vitamin E, carotenoids, astaxanthin and various spices. The main raw material for the synthesis of tea ketone (2,6,6-trimethyl-2-cyclohexene-1,4-dione, KIP). [0003] The conventional preparation method of β-isophorone is to use α-isophorone (3,5,5-trimethylcyclohex-2-en-1-one) as raw material, through isomerization under the action of catalyst. chemical reaction is obtained. α-isophorone and β-isophorone are a pair of isomers, and the formation of β-isophorone invol...

AI Technical Summary

Problems solved by technology

[0004] In view of the complex operation of the above-mentioned isomerization reaction, a large amount of research has been carried out on the catalyst in the prior art, in order to expect to improve the reaction yield:

[0005] U.S. Patent No. 4010205A uses triethanolamine as a catalyst for reactive distillation, and the reaction solution is washed with tartaric acid and brine to obtain β-isophorone; the disadvantage of this technical solution is that the purity of the obtained β-isophorone is relatively low and the The processing process is complex;

[0006] U.S. patents US5907065A and US6005147A use Co 3 o 4 , CaO, Fe 3 o 4 The oxide is used as a catalyst, and the isomerization reaction is carried out by vacuum distillation, and the purity of the obtained β-isophorone can reach more than 97%, but there are many by-products in the reaction and the space-time yield is low;

[0007] Chinese patents CN1288882 and CN1292374 use alkaline hydroxide (KOH, NaOH, etc.) as a catalyst to produce β-isophorone through isomerization reaction, although this technical scheme can obtain β-isophorone with higher purity , but the strong alkaline catalyst will seriously corrode the equipment;

This method also faces problems such as many by-products, low space-time yield, and serious equipment corrosion.